RESEARCH FMRI - COMPATIBLE HIGH RESOLUTION EEG/EP SYSTEM

研究型 FMRI - 兼容的高分辨率 EEG/EP 系统

• 批准号: 6287991
• 负责人: WILLIAM H TRESCHER
• 金额: $ 24.41万
• 依托单位: HUGO W. MOSER RES INST KENNEDY KRIEGER
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6287991
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; brain imaging /visualization /scanning; electroencephalography; evoked potentials; functional magnetic resonance imaging

The goal of this proposal is to support the purchase of a magnetic resonance imaging (MRI)-compatible electroencephalogram (EEG) and high resolution evoked potentials (EP) system only available from Neuroscan, Inc. The Kennedy Krieger Institute (KKI), in collaboration with the Departments of Radiology and Neurology of the Johns Hopkins University (JHU) has established the F. M. Kirby Imaging Center for research in functional imaging of the brain. The EEG/EP system will complement a Phillips 1.5 T MRI scanner recently installed at KKI. The EEG/EP and MRI scanner in the center will be a resource for investigators from KKI, JHU, and the University of Maryland. The EEG/EP system immediately will support 6 active NIH/NIMH-sponsored grants (1 program project, 4 ROls, 1 K award) at KKI and JHU investigating brain-behavior relationships. Areas of active investigation included in this proposal are: the neuroanatomical foundations of learning disabilities due to genetic conditions such as neurofibromatosis type I, fragile X, Turner and Tourette syndromes; neuroanatomical and neurophysiological differences between schizophrenia and bipolar disorder; brain mechanisms of attentional control revealed by fMRI; localization of language processing in patients being prepared for epilepsy surgery; and mechanisms of visual attention in primates. To date, the majority of these studies have focused on neuroanatomical or EEG/EP studies correlated with neuropsychological measures.Combining different modalities of the brain imaging at KKI and JHU has been limited by lack of a MRI-compatible EEG/EP system. Addition of a research dedicated EEG/EP system is critical to the mission of the new imaging center and the proposed system will permit direct correlation of EEG/EP activity with fMRI. This capability is necessary to combine the temporal resolution of EEG/EP activity with the spatial resolution of fMRI. Together these systems will powerfully enhance the existing studies and greatly improve our understanding of brain function in a broad range of disorders being investigated through currently funded NIH/NIMH-sponsored grants.

该提案的目的是支持购买磁共振成像（MRI）兼容的脑电图（EEG）（EEG）（EEG）和高分辨率引起的潜力（EP）系统（仅从Neuroscan Inc.大脑功能成像的研究。 EEG/EP系统将补充最近在KKI安装的Phillips 1.5 T MRI扫描仪。该中心的EEG/EP和MRI扫描仪将是KKI，JHU和马里兰大学的调查人员的资源。 EEG/EP系统将立即支持KKI和JHU调查脑行为关系的6个活跃的NIH/NIMH赞助的赠款（1个计划项目，4个ROLS，1 K奖）。该提案中包括的积极研究领域是：由于遗传疾病（例如I型神经纤维瘤病），脆弱的X，Turner和Tourette综合征，导致学习障碍的神经解剖基础；精神分裂症和躁郁症之间的神经解剖学和神经生理学差异； fMRI揭示了注意力控制的大脑机制；准备进行癫痫手术的患者中语言处理的定位；灵长类动物中视觉注意的机制。迄今为止，这些研究的大多数集中在神经解剖学或脑电图/EP研究上与神经心理学指标相关。.BKI和JHU的不同大脑成像的不同方式受到了缺乏MRI兼容的EEG/EP系统的限制。添加专门的EEG/EP系统的研究对于新成像中心的任务至关重要，而拟议的系统将允许将EEG/EP活动直接相关与fMRI有关。这种能力对于将脑电图/EP活性与fMRI的空间分辨率相结合的时间分辨率是必要的。这些系统将共同增强现有研究，并通过当前资助的NIH/NIMH赞助的赠款在广泛的疾病中大大提高我们对大脑功能的理解。