Dedicated High Performance Human Brain/Preclinical PET

专用高性能人脑/临床前 PET

• 批准号: 6733080
• 负责人: Dean Foster Wong
• 金额: $ 50万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2006-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6733080
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; brain imaging /visualization /scanning; positron emission tomography; three dimensional imaging /topography; bioimaging /biomedical imaging; biomedical equipment purchase; brain imaging /visualization /scanning; positron emission tomography; three dimensional imaging /topography

DESCRIPTION (provided by applicant): This proposal requests a new state of the art high performance positron emission tomography (PET) scanner to replace the GE Advance whole body scanner currently used in our PET center. The new scanner will be dedicated to greatly enhanced human brain imaging, pre-clinical studies of the CNS, and pre-clinical studies from other disciplines, including cancer. Our funded and pending research studies encompass multiple universities, institutes, and schools within and outside Johns Hopkins University including international collaborations. Imaging of non human primate and human CNS neuro-receptors has been the major focus of our previous research, with studies of groups including: children with mental retardation, young adults with schizophrenia, depression, and substance abuse, and diseases in the elderly, including depression, and Parkinson's Disease. A major program of public health and medical significance involves studies of neuro-toxicity. All of these studies require exquisite 3-D resolution sensitivity axial sampling to provide the maximum recovery of radiotracer binding to small structures. Our research plan has four major areas: brain imaging and substance abuse (including alcohol and cocaine), mental illnesses (including schizophrenia and depression), neurological and developmental disorders, and pre-clinical studies for radioligand development in cancer and the CNS. Almost 30 currently funded NIH grants including RO1's, program projects, and center grants, are represented in this application. The scientific scope of our PET program and the number of investigators involved has increased dramatically over the past several years. With many new radiotracers available and increased interest in pre-clinical pharmaceutical collaboration, the opportunities for multiple receptor radiotracers for brain imaging is a reality. These measurements cannot be reproduced by any other methodology with the same degree of quantification, sensitivity, or specificity. These studies go beyond pathophysiology to include drug development and treatment monitoring of neuro-psychiatric disorders. As more is known about brain neurochemistry, the demands for imaging smaller and more intricate structures becomes increasingly important. The new high performance PET camera with advanced crystal designs, larger bore size, and great improvements in 3D resolution and sensitivity over our existing HRRT (CPS Innovations, Knoxville) will allow us to address these challenging issues.

描述（由申请人提供）： 该提案要求新的最先进的高性能正电子发射断层扫描仪（PET）扫描仪，以取代当前在我们的宠物中心使用的GE Advance Advance全身扫描仪。新的扫描仪将致力于极大地增强人脑成像，对中枢神经系统的临床前研究以及包括癌症在内的其他学科的临床前研究。我们资助和未决的研究包括约翰·霍普金斯大学内外的多个大学，机构和学校，包括国际合作。非人类灵长类动物和人类中枢神经系统神经受体的成像一直是我们先前研究的主要重点，其中包括：患有智力低下的儿童，精神分裂症患有精神分裂症，抑郁症和药物滥用的年轻人，以及包括抑郁症和帕金森病的老年人的疾病。公共卫生和医学意义的主要计划涉及神经毒性的研究。所有这些研究都需要精致的3-D分辨率轴向采样，以最大程度地恢复放射性示意剂与小结构的结合。我们的研究计划有四个主要领域：脑成像和滥用药物（包括酒精和可卡因），精神疾病（包括精神分裂症和抑郁症），神经和发育障碍，以及用于癌症和CNS的放射性异构发育的临床前研究。目前，目前将近30个资助的NIH赠款在此申请中代表了RO1，计划项目和中心补助金。在过去的几年中，我们的宠物计划的科学范围和涉及的调查人员数量急剧增加。随着许多新的放射性示例可用，并增加了对临床前药物合作的兴趣，因此多种受体放射性示例进行大脑成像的机会是现实。这些测量不能通过任何其他方法以相同程度的量化，灵敏度或特异性来重现。这些研究超越了病理生理学，包括对神经精神疾病的药物开发和治疗监测。众所周知，脑神经化学对较小和复杂的结构的成像的需求变得越来越重要。具有先进的水晶设计，较大孔径的新型高性能宠物摄像头，以及对现有HRRT（CPS Innovations，Knoxville）的3D分辨率和灵敏度的巨大改进，将使我们能够解决这些具有挑战性的问题。