Biacore S51 Optical Biosensor

Biacore S51 光学生物传感器

• 批准号: 6440327
• 负责人: DAVID G. MYSZKA
• 金额: $ 42.5万
• 依托单位: UNIVERSITY OF UTAH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6440327
• 关键词: DNA binding protein; amyloid proteins; antineoplastics; apoptosis; biological signal transduction; biomedical equipment purchase; biosensor device; human immunodeficiency virus; intermolecular interaction; liposomes; membrane transport proteins; protein protein interaction; virus assembly

DESCRIPTION (provided by the applicant): The Protein Interaction Facility at the University of Utah is interested in expanding its current biosensor technology base by acquiring shared instrument funding to purchase a BIAcore S51 optical biosensor. BIAcore S51, which represents an entirely new platform from BIAcore AB (Uppsala, Sweden), sets a new standard for state-of-the-art biosensor technology. The instrument has several advantages over the Facility's existing biosensor technology, including increased sensitivity, higher throughput, expanded instrument automation, enhanced data analysis software, and the ability to resolve faster reaction kinetics. Instrument time will be shared between six NIH-funded investigators to support basic and applied research involving anticancer agents, HIV assembly, cell signaling, fibril elongation, apoptotic proteins, and cation binding. Each of these investigators has previous experience in applying BIAcore technology in their research and all have a current need for the enhanced capabilities of this new platform. The instrument will be maintained and operated within a well-established University-supported Core Facility, whose function is to provide easy access to instrumentation and expertise required for molecular interaction analysis. The Protein Interaction Facility currently employs the Director and three Ph.D.-level scientists, all of whom are well versed in the application of biosensor technology. When time permits, the BIAcore S51 will be made available for use by external researchers as part of the Facility's effort to establish a national center for biomolecular interaction analysis.

描述（由申请人提供）：蛋白质相互作用设施 犹他大学有兴趣扩展其现有的生物传感器 通过获取共享仪器资金来购买 BIAcore 的技术基础 S51光学生物传感器。 BIAcore S51，代表一个全新的平台 来自 BIAcore AB（瑞典乌普萨拉）的技术为最先进的技术树立了新标准 生物传感器技术。与设施的仪器相比，该仪器有几个优点 现有的生物传感器技术，包括提高灵敏度、更高 吞吐量、扩展的仪器自动化、增强的数据分析软件、 以及解析更快反应动力学的能力。仪器时间将为 由 NIH 资助的六名研究人员共享，以支持基础和应用 研究涉及抗癌剂、HIV 组装、细胞信号传导、原纤维 延伸、凋亡蛋白和阳离子结合。这些调查员中的每一个 拥有在研究中应用 BIAcore 技术的经验 目前，所有人都需要这个新平台的增强功能。这 仪器将在完善的规定内维护和操作 大学支持的核心设施，其功能是提供轻松访问 分子相互作用分析所需的仪器和专业知识。这 蛋白质相互作用设施目前雇用了一名主任和三名 博士级科学家，他们都精通应用 生物传感器技术。当时间允许时，将提供 BIAcore S51 供外部研究人员使用，作为该设施努力建立一个 国家生物分子相互作用分析中心。