Wavelet-Based AROS Compresion of Cytogenetic Images

基于小波的细胞遗传学图像 AROS 压缩

• 批准号: 6403931
• 负责人: QIANG WU
• 金额: $ 10万
• 依托单位: ADVANCED DIGITAL IMAGING RESEARCH, LLC
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6403931
• 关键词: bioimaging /biomedical imaging; computer data analysis; computer program /software; computer system design /evaluation; cytogenetics; data management; digital imaging; fluorescent in situ hybridization; image processing; technology /technique development; bioimaging /biomedical imaging; computer data analysis; computer program /software; computer system design /evaluation; cytogenetics; data management; digital imaging; fluorescent in situ hybridization; image processing; technology /technique development

DESCRIPTION (provided by applicant): The goal of this project is to develop innovative image compression techniques to make the digital storage, archiving, and communication of cytogenetics images much more efficient and faster, thereby significantly reducing the storage and transfer costs of digital cytogenetics imaging instruments in clinical diagnosis and in genetics and cancer research. Our approach takes advantage that, for mostcytogenetics images, the regions of interest to cytogeneticists are well determined and segmented before storage. The recently developed wavelet-based arbitrary region of support (AROS) coding approach offers an effective means of region-segmented image compression, and promises significant improvement over currently available techniques. In Phase 1 we will study the feasibility of wavelet-based AROS compression of monochrome cytogenetics images. We will evaluate in terms of compression ratios, compression gains, coding speed, and error resilience on test images including 0-banding chromosome spreads and karyotypes, FISH and cDNA images. If the proposed approach can effect a significant improvement, in Phase 2 the technique will be extended to and tested on multispectral FISH/M-FISH and cDNA microarray images. When fully developed, the new technology will be made available to Applied Imaging (AIC) for integration into the PowerGene cytogenetics automation products. This will result in far more cost-effective commercial instruments. PROPOSED COMMERCIAL APPLICATION: As soon as the new techniques are developed and qualified for routine application, they will be made available to AIC for incorporation into the PowerGene product line of cytogenetics automation equipment, both in new systems sold and as an upgrade to existing systems already in use in cytogenetics labs, thus commercializing the technology quickly.

描述（由申请人提供）：该项目的目的是开发 创新图像压缩技术以使数字存储，归档， 和细胞遗传学图像的通信效率更高，更快， 从而大大降低数字的存储和转移成本 临床诊断和遗传学和 癌症研究。我们的方法利用了，对于多数循环学 图像，细胞遗传学家感兴趣的区域是确定的，并且 在存储前进行细分。最近开发的基于小波的任意区域 支持（AROS）编码方法提供了有效的区域细分方式 图像压缩，并有望比当前有重大改进 可用技术。 在第1阶段，我们将研究基于小波的AROS压缩的可行性 单色细胞遗传学图像。我们将根据压缩评估 测试图像的比率，压缩速度，编码速度和错误弹性 包括0带染色体扩散和核型，鱼类和cDNA图像。如果 提出的方法可以影响显着改善，在第2阶段中 技术将扩展到多光谱鱼/m鱼和cDNA 微阵列图像。当完全开发时，将制定新技术 可用于应用成像（AIC）以集成到电力机中 细胞遗传学自动化产品。这将导致更具成本效益 商业仪器。 拟议的商业应用： 一旦开发新技术并有资格用于常规应用，他们就会 将提供给AIC以将其纳入Powergene产品线 细胞遗传学自动化设备，包括新系统的销售和升级 现有的系统已经在细胞遗传学实验室中使用，因此将技术商业化 迅速地。