WAVELET ENHANCEMENT OF CHROMOSOME BANDING PATTERNS

染色体带型的小波增强

• 批准号: 6181715
• 负责人: QIANG WU
• 金额: $ 26.06万
• 依托单位: ADVANCED DIGITAL IMAGING RESEARCH, LLC
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-09-20 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6181715
• 关键词: artificial intelligence; bioengineering /biomedical engineering; bioimaging /biomedical imaging; chromosome aberrations; chromosomes; computer data analysis; computer program /software; computer simulation; cytogenetics; digital imaging; image enhancement; image processing; molecular dynamics

This project aims to develop and commercialize significantly improved software for digital enhancement of the detail of chromosome banding patterns in microscopic images. These investigators have developed an innovative technique for this application, based upon wavelet transforms and multiresolution image analysis. Used with modern computerized chromosome analysis the proposed technique promises significantly improved enhancement of chromosome banding patterns and more effective visual detection of subtle rearrangements. This will help clinicians and researchers detect previously invisible or sub-visible band pattern alterations in conventional and high resolution banding. It will significantly increase the ability of automated instruments to assist the evaluation of chromosome alterations in clinical samples and in normal and neoplastic mammalian cells. During Phase I we implemented and tested three wavelet transforms with desirable mathematical properties. We developed a prototype multiresolution image processing system for chromosome enhancement. We obtained extremely encouraging results, strongly suggesting that these techniques offer considerably improved enhancement capability over conventional methods. and clearly demonstrating the feasibility of this approach. In Phase II we will complete the implementation and refinement of the software. We will implement several wavelet design approaches and evaluate many wavelet transform basis function sets that potentially can bring out relevant detail in chromosome banding patterns. PROPOSED COMMERCIAL APPLICATIONS: As soon as the new enhancement techniques are developed and qualified for routine application, they will be incorporated into PSII's PowerGene products, both in new systems sold and as an upgrade to existing systems.

该项目旨在开发和商业化显着改进的软件，用于对显微图像中染色体带型图案的细节进行数字增强。这些研究人员基于小波变换和多分辨率图像分析，为此应用开发了一种创新技术。与现代计算机化染色体分析一起使用，所提出的技术有望显着改善染色体带型的增强，并更有效地视觉检测微妙的重排。这将帮助临床医生和研究人员检测传统和高分辨率条带中以前不可见或亚可见的条带图案变化。它将显着提高自动化仪器协助评估临床样本以及正常和肿瘤性哺乳动物细胞中染色体改变的能力。在第一阶段，我们实现并测试了具有理想数学特性的三种小波变换。我们开发了用于染色体增强的原型多分辨率图像处理系统。我们获得了极其令人鼓舞的结果，强烈表明这些技术比传统方法提供了显着改进的增强能力。并清楚地证明了这种方法的可行性。在第二阶段我们将完成软件的实施和完善。我们将实施几种小波设计方法并评估许多小波变换基函数集，这些函数集可能会带来染色体带型模式的相关细节。拟议的商业应用：一旦新的增强技术被开发出来并符合日常应用的资格，它们将被纳入 PSII 的 PowerGene 产品中，无论是在销售的新系统中还是作为现有系统的升级。