SIMULATED ANNEALING: AUTOMATED CHROMOSOME KARYOTYPING

模拟退火：自动染色体核型分析

• 批准号: 2889279
• 负责人: QIANG WU
• 金额: $ 27万
• 依托单位: ADVANCED DIGITAL IMAGING RESEARCH, LLC
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-08-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2889279
• 关键词: bioengineering /biomedical engineering; biomedical automation; chromosomes; computer program /software; computer simulation; computer system design /evaluation; cytogenetics; image processing; karyotype; mathematical model

DESCRIPTION (Adapted from investigator's abstract): Application "Simulated Annealing for Automated Chromosome Karyotyping" by Wu et al., is aimed to finalize development and commercialize automated karyotyping software which will be significantly improved compared to the currently available techniques. This will be accomplished by further implementing mathematical models for combinatorial optimization of the chromosome classification problem, recently developed by the authors. New approach enables optimal concurrent assignment of all chromosomes in a cell in order to make the entire karyotype most accurate. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE

描述（根据调查员的摘要改编）：应用 Wu等人的“模拟自动染色体核分型”的“模拟退火”， 旨在最终确定开发和商业化自动核分型 与当前的软件相比将大大改进 可用技术。 这将通过进一步实施来实现 染色体组合优化的数学模型 分类问题，最近由作者开发。 新方法 实现在单元中所有染色体的最佳并发分配 为了使整个核型最准确。 拟议的商业应用程序：不可用

项目成果

Subspace-based prototyping and classification of chromosome images.

基于子空间的染色体图像原型设计和分类。

• DOI: 10.1109/tip.2005.852468
• 发表时间: 2005
• 期刊: IEEE transactions on image processing : a publication of the IEEE Signal Processing Society
• 作者: Wu,Qiang;Liu,Zhongmin;Chen,Tiehan;Xiong,Zixiang;Castleman,KennethR
• 通讯作者: Castleman,KennethR