MRI UPGRADE:BIDMC CENTER FOR BASIC MR RESEARCH

MRI 升级：BIDMC 基础 MR 研究中心

• 批准号: 6053106
• 负责人: DEBORAH BURSTEIN
• 金额: $ 41.3万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6053106
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; magnetic resonance imaging

The Center for Basic MR Research at the Radiology Department of Beth Israel Deaconess Medical Center (BIDMC) contains a Bruker BIOSPEC system and a Bruker DRX system. These instruments are currently integrated and are used interactively by a large group of NIH funded investigators, as well as other investigators pursuing pilot studies for future NIH funding. The purpose of this proposal is to upgrade the MRI capabilities of the Center in order to have a state-of-the-art facility for the large number of NIH funded investigators who utilize it. In particular, we are requesting: 1. An upgrade of the BIOSPEC rf electronics from MSL based electronics to Avance based electronics. 2. An upgrade of the rf shielded room of the BIOSPEC to an rf/steel shielded room. 3. An upgrade of the DRX hardware, including an upgrade of the microimaging probe to the micro 2. 5 and the digitizer and phase coherent DDS option. The Avance upgrade will ensure enhanced reliability, signal to noise, and faster imaging capabilities than the current 12 year old MSL electronics. The rf/steel shielded room will enable the magnet to be ramped up to 4.7 T from the present 2 T field strength, increasing the signal to noise and hence resolution of all studies. The micro2.5 probe will replace the original unshielded 10 year old microimaging probe. This new probe will increase gradient switching, imaging speed, and will significantly improve in vivo mouse imaging. Similarly, the upgraded digitizer will enable faster imaging and simpler pulse programming. The proposed upgrade will support 21 projects from 18 investigators at 10 departments in 5 different institutions. 14 projects are currently NIH funded, and 4 others have NIH applications currently under review.

贝斯以色列女执事医疗中心 (BIDMC) 放射科的基础 MR 研究中心包含布鲁克 BIOSPEC 系统和布鲁克 DRX 系统。这些仪器目前已被集成，并由一大批 NIH 资助的研究人员以及其他为未来 NIH 资助进行试点研究的研究人员交互使用。该提案的目的是升级该中心的 MRI 能力，以便为大量 NIH 资助的研究人员提供最先进的设施。我们特别要求： 1. 将 BIOSPEC 射频电子器件从基于 MSL 的电子器件升级到基于 Avance 的电子器件。 2. BIOSPEC射频屏蔽室升级为射频/钢屏蔽室。 3. DRX硬件的升级，包括将微成像探头升级到micro 2. 5以及数字化仪和相位相干DDS选项。 Avance 升级将确保比当前已有 12 年历史的 MSL 电子产品增强可靠性、信噪比和更快的成像能力。射频/钢屏蔽室将使磁体能够从目前的 2 T 场强升至 4.7 T，从而提高信噪比，从而提高所有研究的分辨率。 micro2.5 探头将取代原来已有 10 年历史的非屏蔽显微成像探头。这种新探针将提高梯度切换、成像速度，并将显着改善小鼠体内成像。同样，升级后的数字化仪将实现更快的成像和更简单的脉冲编程。拟议的升级将支持 5 个不同机构 10 个部门的 18 位研究人员的 21 个项目。目前有 14 个项目获得 NIH 资助，另外 4 个项目目前正在审查 NIH 申请。

项目成果

Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease.

隐性多囊肾病小鼠模型的磁共振成像评估。

• 发表时间: 2002
• 期刊: Comparative medicine.
• 作者: Sun,Yanping;Zhou,Jing;Stayner,Cherie;Munasinghe,Jeeva;Shen,Xiaohua;Beier,DavidR;Albert,MitchellS
• 通讯作者: Albert,MitchellS