BIDMC 9.4T 20cm Biospec MRI System

BIDMC 9.4T 20cm Biospec MRI 系统

• 批准号: 7842438
• 负责人: DEBORAH BURSTEIN
• 金额: $ 239.5万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-02 至 2010-09-01
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7842438
• 关键词: Animal Disease Models; Animal Model; Animals; Area; Arts; Commit; Communities; Computer software; Development; Disease; Electronics; Employment; Equipment; Fluorescence; Funding; Future; Goals; Housing; Human Resources; Image; Imaging Techniques; Industry; Institute of Medicine (U.S.); Investigation; Israel; Magnetic Resonance Imaging; Medical; Medical center; Methodology; Mus; Nuclear; Occupations; Radiology Specialty; Rattus; Research; Research Infrastructure; Research Personnel; Scientist; Services; Speed; System; Time; Tissues; Training; United States National Institutes of Health; Update; Validation; animal facility; base; instrument; instrumentation; medical schools; metabolic abnormality assessment; programs; public health relevance; research study; tool

DESCRIPTION (provided by applicant): Magnetic resonance imaging (MRI) of animals is continuing to gain importance as a means of development and validation of new MRI techniques, as well as a necessary tool for tracking of tissue status in animal studies of disease, replacing previously invasive and destructive methodologies. The Center for Basic MR Research is a facility of the Radiology Department at Beth Israel Deaconess Medical Center (BIDMC) and based in the Harvard Medical School area for MRI of tissues and animal models of disease. The facility currently includes an 8.5T 9 cm vertical bore system and a 4.7T 40 cm bore horizontal system, and currently serves the needs of 11 R01 / P01 / U01 NIH projects and 4 training / pilot NIH projects, as well as 3 R01 pending projects, and 3 other projects within the community. The 8.5T system was originally purchased in 1986 (with periodic upgrades of parts of the electronics and probes through 1999), and the 4.7T system was purchased in 1999. Both systems are outdated and have significant limitations for the current (and future) projects of the Center. The current call for proposals for the High End Instrumentation Program provides an opportunity to upgrade the Center by purchasing a state-of-the-art MRI instrument. Our proposed plan is to purchase a 9.4 Tesla 20 cm bore Biospec Imaging system with a microimaging gradient insert to replace both systems. The replacement of the 4.7T and 8.5T systems with a 9.4T 20 cm bore system, with the associated higher field strength and updated electronics and software, will provide much needed improvement in image quality and image acquisition speed for the rat and mouse studies being done on the current systems. The upgraded electronics and software will also enable experiments that are currently not feasible. The Center is housed at a satellite facility of BIDMC, the Harvard Institutes of Medicine (HIM). Within the next year, BIDMC has committed to moving the lab over to the main BIDMC campus. There it will be in close proximity to the Longwood Small Animal Imaging Facility (SAIF) with bioluminenscence, multi- and hyper-spectral fluorescence, microCT, microPET/CT, microSPECT/CT. In addition, BIDMC has just purchased a Dynamic Nuclear Polarization (DNP) system which will allow for unprecedented metabolic studies in animal models of disease. A satellite animal facility is available that will allow animals to be brought in and out for imaging in both MRI and the SAIF. In addition, a full time dedicated lab manager was hired to support the needs of the biomedical community by providing the MRI expertise. In summary, the Center currently supports a wide range of NIH funded investigators. The support provided by a full time lab manager, adjacent small animal imaging facility for non-MRI imaging, availability of DNP equipment and expertise, and in & out animal facility, will provide a unique infrastructure for investigation of disease in animal models. PUBLIC HEALTH RELEVANCE: The Center for Basic MR Research at Beth Israel Deaconess Medical Center (BIDMC) currently serves BIDMC and the surrounding Harvard Medical area with magnetic resonance imaging (MRI) instrumentation for studying animal models of disease. The instrumentation is now between 10 and 23 years old; therefore the goal is to replace the outdated systems with state of the art MRI instrumentation. Through this improvement, jobs will be generated in the construction industry (for sitting the system), for lab technicians, scientists, and the employment of manufacturing and service personnel within the MRI industry.

描述（由申请人提供）：动物磁共振成像（MRI）作为新 MRI 技术的开发和验证手段，以及在动物疾病研究中跟踪组织状态的必要工具，正在不断获得重要性，取代以前的侵入性和破坏性方法。基础 MR 研究中心是贝斯以色列女执事医疗中心 (BIDMC) 放射科的一个设施，位于哈佛医学院区域，用于组织和动物疾病模型的 MRI。该设施目前包括一个8.5T 9厘米垂直孔径系统和一个4.7T 40厘米孔径水平系统，目前服务于11个R01 / P01 / U01 NIH项目和4个培训/试点NIH项目以及3个待定的R01项目的需求项目，以及社区内的其他 3 个项目。 8.5T 系统最初于 1986 年购买（到 1999 年定期升级电子部件和探头），4.7T 系统于 1999 年购买。这两个系统都已过时，并且对当前（和未来）项目有很大的限制中心的。当前的高端仪器项目提案征集提供了通过购买最先进的 MRI 仪器来升级该中心的机会。我们提议的计划是购买一个 9.4 特斯拉、20 厘米孔径的 Biospec 成像系统，并带有微成像梯度插入件来替换这两个系统。用 9.4T 20 cm 孔径系统替换 4.7T 和 8.5T 系统，以及相关的更高场强和更新的电子设备和软件，将为正在进行的大鼠和小鼠研究提供急需的图像质量和图像采集速度改进。在当前系统上完成。升级后的电子设备和软件也将使目前不可行的实验成为可能。该中心设在 BIDMC 的卫星设施内，即哈佛大学医学院 (HIM)。 BIDMC 承诺在明年内将实验室迁至 BIDMC 主园区。在那里，它将紧邻朗伍德小动物成像设施 (SAIF)，配备生物发光、多光谱和高光谱荧光、microCT、microPET/CT、microSPECT/CT。此外，BIDMC 刚刚购买了动态核极化 (DNP) 系统，该系统将允许在疾病动物模型中进行前所未有的代谢研究。卫星动物设施可让动物进出进行 MRI 和 SAIF 成像。此外，还聘请了一名全职专用实验室经理，通过提供 MRI 专业知识来支持生物医学界的需求。总之，该中心目前支持广泛的 NIH 资助的研究人员。由全职实验室经理、邻近的非 MRI 成像小动物成像设施、DNP 设备和专业知识的可用性以及进出动物设施提供的支持，将为动物模型疾病研究提供独特的基础设施。 公共健康相关性：贝斯以色列女执事医疗中心 (BIDMC) 的基础 MR 研究中心目前为 BIDMC 和周边的哈佛医学区提供磁共振成像 (MRI) 仪器，用于研究疾病动物模型。该仪器目前的使用年限为 10 至 23 年；因此，我们的目标是用最先进的 MRI 仪器取代过时的系统。通过这一改进，将为建筑行业（用于安装系统）、实验室技术人员、科学家以及 MRI 行业内的制造和服务人员创造就业机会。