MEMBRANE PROTEIN STRUCTURE FUNCTION RELATIONSHIPS

膜蛋白结构功能关系

• 批准号: 6223590
• 负责人: Howard Ronald KABACK
• 金额: $ 1万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223590
• 关键词: meeting /conference /symposium; membrane proteins; protein structure function; structural biology; travel

DESCRIPTION (taken from the application) Of the genomes sequenced thus far, about 30 percent of the gene products are predicted to be polytopic transmembrane proteins. These hydrophobic proteins catalyze a multitude of essential functions, from oxidative phosphorylation and electron transfer to transport of molecules into and out of cells and intracellular organelles to signal transduction across membranes, and many are important with regard to human disease. Although advances in molecular biology and biochemistry over the past 15 years have led to the characterization, purification and modification of this class of proteins, only a handful of these proteins have been crystallized in a form that allows structure determination at atomic resolution, which is essential for understanding mechanism of action. Furthermore, many membrane proteins require conformation flexibility in order to function, making it imperative to obtain dynamic information as well in order to fully understand function. Thus, a major problem in this area is the difficulty inherent in obtaining structural information at a relevant level of resolution.The purpose of this symposium is to bring together a wide range of key investigators from a diversity of disciplines studying structure/function relationships at the molecular level in polytopic membrane proteins involved in a variety of functions from as many different perspectives as possible. No other such all encompassing conferences specific to this problem have ever been held and it is expected that by bringing such individuals together, discussions will focus the field on the importance of high resolution structure-function studies in order to understand this important class of biological molecules. Thus, this Symposium will cover the remarkable developments that have occurred in the area over the past 30 years, as well as what portends for the future. Due to the fact that this symposium will be so unique it is critical to the careers of graduate students and postdoctoral follows interested in furthering the understanding of these advancing studies. To this end, we have encouraged the session chairs to invite younger investigators whenever possible. In addition, a workshop on "Emerging Techniques" and a poster session are included in the program. We also intend to actively encourage graduate students and postdoctoral fellows to attend the meeting and participate in these sessions.

描述（取自应用程序） 到目前为止，在测序的基因组中，大约30％的基因产物是 预测为多重跨膜蛋白。这些疏水蛋白 从氧化磷酸化和 电子向分子传输到细胞中，并从细胞中转移 细胞内细胞器，以跨膜信号转导信号，许多是 关于人类疾病重要。尽管分子生物学的进步 在过去的15年中，生物化学导致了特征， 纯化和修改这类蛋白质，只有少数 这些蛋白质已以允许结构的形式结晶 原子分辨率的决心，这对于理解至关重要 作用机理。此外，许多膜蛋白需要构象 灵活性以便运行，因此必须获得动态 信息也是为了充分理解功能。因此，一个专业 该领域的问题是获得结构的固有的困难 相关解决方案的信息。本专题讨论会的目的是 将各种各样的重要调查员聚集在一起 学科研究分子水平的结构/功能关系 来自多种功能的多种膜蛋白来自多种功能 尽可能不同的观点。没有其他所有涵盖会议 特定于这个问题一直存在，预计 将这些人聚集在一起，讨论将把领域集中在 高分辨率结构功能研究的重要性以了解 这类重要的生物分子。因此，该研讨会将涵盖 过去30个地区发生的显着发展 多年，以及什么预示着未来。由于这个事实 研讨会将是如此独特，对研究生的职业至关重要 博士后遵循有兴趣进一步了解这些的理解 进步研究。为此，我们鼓励会议主席邀请 尽可能的年轻调查员。此外，关于“新兴的研讨会” 该程序中包括技术和海报会话。我们还打算 积极鼓励研究生和博士后研究员参加 开会并参加这些会议。