GORDON RESEARCH CONFERENCE ON RNA EDITING

戈登 RNA 编辑研究会议

• 批准号: 6228523
• 负责人: Ronald B. Emeson
• 金额: $ 2.88万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-21 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6228523
• 关键词: RNA; meeting /conference /symposium; posttranscriptional RNA processing; travel

DESCRIPTION (from the application): Gordon Research Conferences on RNA Editing are planned for January, 2001 and January 2003 in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA, which results in the insertion, deletion, or substitution of nucleotides. RNA editing can therefore correct, extend, or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine-tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences that are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard, the cis-active regulatory elements and trans- acting factors mediating a number of editing processes are being evaluated at both the molecular and genetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being examined at the evolutionary and developmental levels, as well as in multiple tissues and diverse organisms. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Information about other RNA processing events is also likely to have implications for understanding RNA editing mechanisms, and investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

描述（来自应用程序）：关于RNA编辑的Gordon研究会议 计划于2001年1月和2003年1月在加利福尼亚州的文图拉（Ventura）举行。 RNA 编辑是RNA的转录或后修改，结果 在插入，缺失或取代核苷酸中。 RNA编辑可以 因此，正确，扩展或多样化了编码的信息 相应的基因组序列，可以显着改变 修改后的RNA。例如，在哺乳动物中央紧张中编辑事件 系统可以增加神经递质受体表达的多样性和 用来有效调节神经元信号通路。同样重要 是许多RNA编辑过程的细胞调节 用于发育，组织特异性和代谢微调蛋白质 功能和生化途径。我们对分子机制的理解 基础RNA编辑及其生物出现已达到关键 假设和实验方法交叉施肥的阶段是 在未来十年的研究中，对重点至关重要。 研究人员之间有许多共同的问题和实验目标 尽管发生了编辑的生物多样性，但RNA编辑尽管发生了多种多样，并且 修改的序列中的明显差异。对 对每个编辑系统的理解是对RNA的基本描述 这些过程修改的底物。同样的问题 关于机制，特异性，忠诚度和加工性的兴趣 RNA编辑可以通过生化和分子的结合来解决 生物技术以及体外编辑系统的开发。 在这方面，顺式主动的调节元件和转移因素 介导许多编辑过程正在评估 分子和遗传水平。了解这些的结构和功能 在不同的特征级别的因素 编辑系统是拟议的戈登研究的重要目标 会议。还有其他编辑系统尚未发展到体外系统 或直到最近才描述。戈登研究会议将 培养信息和技术转移，将促进 这些区域。 RNA编辑调节的细胞和分子方面也广泛 在进化和发展层面以及在 多种组织和多种生物。 RNA的生物学意义 编辑是拟议会议的各个方面的反复出现的主题。 有关其他RNA处理事件的信息也可能具有 了解RNA编辑机制和研究人员的含义 因此，在RNA处理的其他领域工作将参与 适当的会话以刺激这些相关领域之间的交换。