GORDON RESEARCH CONFERENCE ON RNA EDITING

戈登 RNA 编辑研究会议

• 批准号: 6228523
• 负责人: Ronald B. Emeson
• 金额: $ 2.88万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-21 至 2003-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6228523
• 关键词: RNA; meeting /conference /symposium; posttranscriptional RNA processing; travel

DESCRIPTION (from the application): Gordon Research Conferences on RNA Editing are planned for January, 2001 and January 2003 in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA, which results in the insertion, deletion, or substitution of nucleotides. RNA editing can therefore correct, extend, or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and serve to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine-tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences that are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard, the cis-active regulatory elements and trans- acting factors mediating a number of editing processes are being evaluated at both the molecular and genetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being examined at the evolutionary and developmental levels, as well as in multiple tissues and diverse organisms. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Information about other RNA processing events is also likely to have implications for understanding RNA editing mechanisms, and investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

描述（来自申请）：戈登 RNA 编辑研究会议 计划于 2001 年 1 月和 2003 年 1 月在加利福尼亚州文图拉举行。核糖核酸 编辑是 RNA 的共转录或转录后修饰，其结果是 核苷酸的插入、缺失或取代。 RNA编辑可以 因此，纠正、扩展或多样化编码内的信息 相应的基因组序列，可以显着改变 修饰的 RNA。例如，编辑哺乳动物中枢神经内的事件 系统可以增加神经递质受体表达的多样性 有效调节神经信号通路。同样重要 许多 RNA 编辑过程的细胞调节提供了 用于蛋白质的发育、组织特异性和代谢微调 功能和生化途径。我们对分子机制的理解 潜在的RNA编辑及其生物学发生已达到关键 假设和实验方法交叉融合的阶段 对于未来十年的研究重点至关重要。 研究人员之间存在许多常见问题和实验目标 尽管发生编辑的生物体具有多样性，但 RNA 编辑 被修改的序列明显不同。重要的是 了解每一个编辑系统就是对RNA的基本描述 通过这些过程改性的基材。同样的一般问题 对机制、特异性、保真度和持续性的兴趣 RNA编辑可以通过生物化学和分子生物学的结合来解决 生物技术与体外编辑系统的发展相结合。 在这方面，顺式活性调节元件和反式作用因子 双方正在对调解许多编辑过程进行评估 分子和基因水平。了解这些的结构和功能 不同因素之间共同或不同特征水平的因素 编辑系统是戈登研究提议的一个重要目标 会议。还有其他编辑系统尚未发展到体外系统 或者最近才被描述。戈登研究会议将 促进信息和技术转让，从而促进发展 这些领域。 RNA 编辑调控的细胞和分子方面也广泛 在进化和发展层面以及在 多种组织和多种生物体。 RNA的生物学意义 编辑是拟议会议各个方面反复出现的主题。 有关其他 RNA 加工事件的信息也可能具有 对理解 RNA 编辑机制和研究人员的影响 从事 RNA 加工其他领域的工作，因此将参加 适当的会议来促进这些相关领域之间的交流。