RNA Editing Gordon Research Conference (2005 and 2007)

RNA 编辑戈登研究会议（2005 年和 2007 年）

• 批准号: 7114877
• 负责人: KENNETH D STUART
• 金额: $ 4.58万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7114877
• 关键词: meeting /conference /symposium; posttranscriptional RNA processing; travel

DESCRIPTION (provided by applicant): A Gordon Research Conference on RNA Editing is planned for January 2005 and January 2007 in Ventura, California. This biannual conference is the only regularly scheduled meeting devoted exclusively to RNA editing and RNA modification. The term RNA editing refers to a wide range of enzymatic activities, which specifically alter the primary sequence of a transcript. Mechanistically, there are many different types of editing that alter the sequence of an RNA from that encoded by the gene. By altering the coding capacity of a transcript, RNA editing can generate alternative mRNAs that encode proteins with different biological functions. Strikingly, RNA editing is critical for proper development and/or function of the nervous system in mice, worms, and flies. The variety and extent of RNA modifications are equally astonishing, with almost 100 different nucleosides reported in all types of RNAs. RNA modifications are believed to influence many vital processes, including genetic imprinting, RNA splicing, and the efficiency or fidelity of protein synthesis. Despite the diversity of substrates, mechanisms, and biological consequences, many of the critical theoretical and technical questions for the different types of RNA editing and modification are similar. The 2005 RNA Editing Conference will provide scientists investigating these diverse processes with a unique opportunity to interact at a single meeting in order to discuss new hypotheses and mechanistic paradigms, exchange information about experimental strategies, and initiate collaborations. The meeting will bring together a relatively small group of scientists for five days in a casual setting that fosters informal discussion among participants. Established leaders in the field as well as junior scientists will be invited. Talks will be presented in the mornings and evenings, with the afternoons reserved for informal discussions, recreation, and poster sessions. To promote crossfertilization between the editing and modification communities, the program will be organized in thematic sessions, which will focus on questions of common interest.

描述（由申请人提供）：戈登 RNA 编辑研究会议计划于 2005 年 1 月和 2007 年 1 月在加利福尼亚州文图拉举行。这次会议每两年一次，是唯一专门讨论 RNA 编辑和 RNA 修饰的定期会议。 RNA编辑一词指的是广泛的酶活性，它们特异性地改变转录物的一级序列。从机制上讲，有许多不同类型的编辑可以改变基因编码的 RNA 序列。通过改变转录本的编码能力，RNA 编辑可以生成替代的 mRNA，编码具有不同生物功能的蛋白质。引人注目的是，RNA 编辑对于小鼠、蠕虫和果蝇神经系统的正常发育和/或功能至关重要。 RNA 修饰的多样性和程度同样令人惊讶，据报道，所有类型的 RNA 中都有近 100 种不同的核苷。 RNA 修饰被认为会影响许多重要过程，包括遗传印记、RNA 剪接以及蛋白质合成的效率或保真度。尽管底物、机制和生物学后果各不相同，但不同类型的 RNA 编辑和修饰的许多关键理论和技术问题是相似的。 2005 年 RNA 编辑会议将为研究这些不同过程的科学家提供在一次会议上进行互动的独特机会，以便讨论新的假设和机制范式、交换有关实验策略的信息并启动合作。这次会议将在为期五天的休闲环境中聚集相对较小的科学家小组，以促进参与者之间的非正式讨论。将邀请该领域的知名领导者以及初级科学家。演讲将在早上和晚上进行，下午则用于非正式讨论、娱乐和海报会议。为了促进编辑和修改社区之间的交流，该计划将举办专题会议，重点讨论共同感兴趣的问题。