RNA Editing Gordon Research Conference (2005 and 2007)

RNA 编辑戈登研究会议（2005 年和 2007 年）

• 批准号: 6880203
• 负责人: DONNA M DRISCOLL
• 金额: $ 4.4万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-20 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6880203
• 关键词: meeting /conference /symposium; posttranscriptional RNA processing; travel

DESCRIPTION (provided by applicant): A Gordon Research Conference on RNA Editing is planned for January 2005 and January 2007 in Ventura, California. This biannual conference is the only regularly scheduled meeting devoted exclusively to RNA editing and RNA modification. The term RNA editing refers to a wide range of enzymatic activities, which specifically alter the primary sequence of a transcript. Mechanistically, there are many different types of editing that alter the sequence of an RNA from that encoded by the gene. By altering the coding capacity of a transcript, RNA editing can generate alternative mRNAs that encode proteins with different biological functions. Strikingly, RNA editing is critical for proper development and/or function of the nervous system in mice, worms, and flies. The variety and extent of RNA modifications are equally astonishing, with almost 100 different nucleosides reported in all types of RNAs. RNA modifications are believed to influence many vital processes, including genetic imprinting, RNA splicing, and the efficiency or fidelity of protein synthesis. Despite the diversity of substrates, mechanisms, and biological consequences, many of the critical theoretical and technical questions for the different types of RNA editing and modification are similar. The 2005 RNA Editing Conference will provide scientists investigating these diverse processes with a unique opportunity to interact at a single meeting in order to discuss new hypotheses and mechanistic paradigms, exchange information about experimental strategies, and initiate collaborations. The meeting will bring together a relatively small group of scientists for five days in a casual setting that fosters informal discussion among participants. Established leaders in the field as well as junior scientists will be invited. Talks will be presented in the mornings and evenings, with the afternoons reserved for informal discussions, recreation, and poster sessions. To promote crossfertilization between the editing and modification communities, the program will be organized in thematic sessions, which will focus on questions of common interest.

描述（由申请人提供）：计划于2005年1月和2007年1月在加利福尼亚州的文图拉（Ventura）举行有关RNA编辑的研究会议。这次双年度会议是唯一专门针对RNA编辑和RNA修改的定期会议。术语RNA编辑是指广泛的酶促活性，这些酶促活性专门改变了转录本的主要序列。从机械上讲，有许多不同类型的编辑可以改变RNA的序列，从该基因编码的序列。通过改变转录本的编码能力，RNA编辑可以生成具有不同生物学功能的蛋白质的替代mRNA。令人惊讶的是，RNA编辑对于小鼠，蠕虫和苍蝇中神经系统的正常发育和/或功能至关重要。 RNA修饰的多样性和程度同样令人惊讶，所有类型的RNA中报告了几乎100种不同的核苷。 RNA修饰被认为会影响许多重要过程，包括遗传印迹，RNA剪接以及蛋白质合成的效率或保真度。尽管底物，机制和生物学后果的多样性，但针对不同类型的RNA编辑和修改的许多关键理论和技术问题都是相似的。 2005年的RNA编辑会议将为科学家提供调查这些多样性过程的独特机会，可以在一次会议上进行互动，以讨论新的假设和机械范式，交流有关实验策略的信息以及启动合作。这次会议将在一个随意的环境中汇集一群相对较小的科学家五天，从而促进了参与者之间的非正式讨论。将邀请该领域的成熟领导人以及初级科学家。谈判将在早晨和晚上进行，下午预留了非正式的讨论，娱乐和海报会议。为了促进编辑和修改社区之间的交叉利用，该计划将在主题会议中进行组织，该课程将重点放在共同利益的问题上。