Post-transcriptional Control of Gene Expression

基因表达的转录后控制

• 批准号: 6507218
• 负责人: Lynne E Maquat
• 金额: $ 0.7万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6507218
• 关键词: gene expression; meeting /conference /symposium; messenger RNA; molecular genetics; posttranscriptional RNA processing; travel

DESCRIPTION (provided by applicant): This proposal requests partial funding for the Federation of American Societies of Experimental Biology (FASEB) conference entitled "Post- Transcriptional Control of Gene Expression: Effectors of mRNA Decay". This conference will be held July 6-11, 2002 in Tucson, Arizona. MRNA decay plays a major role in determining the level at which genes are expressed. The advent of microarrays has firmly established two critical concepts: (1) the half-lives of different mRNAs differ in ways that correlate with mRNA function, and (2) the half-lives of individual mRNAs vary in response to metabolic conditions that relate to mRNA function. Therefore, understanding the mechanisms of mRNA degradation becomes very important to understanding how genes are regulated. This understanding becomes all the more valuable considering the many cases where manipulation of mRNA degradation can be used as means of disease therapy. Participants will include those studying mRNA decay in both prokaryotes and eukaryotes, making this meeting unique from all others in offering all individuals who study mRNA decay a chance to exchange ideas. There are 36 distinguished invited speakers, 10 of whom are women and 7 of whom are outstanding scientists at the level of Assistant Professor or less. The goal of the meeting is to gather approximately 120 individuals in a conference environment that allows the free flow in information via a keynote talk, platform presentations, poster presentations, round-table discussions and workshops. An Abstract Booklet will be created to provide the abstracts and mailing/email addresses of all participants as a supplementary way to exchange information. Topics to be covered include the recent advances in understanding multifunctional nucleases of prokaryotes and eukaryotes, how mRNA localization and mRNA translation affect mRNA half-lives, cis-acting sequences and trans-acting effectors of mRNA half-lives, and the use of RNA as a tool and target for drug design.

描述（由申请人提供）： 该提案要求为美国联合会提供部分资金 实验生物学会 (FASEB) 会议题为“后 基因表达的转录控制：mRNA 衰变的效应器”。这 会议将于2002年7月6日至11日在亚利桑那州图森举行。 mRNA 衰变 在决定基因表达水平方面发挥着重要作用。 这 微阵列的出现牢固地确立了两个关键概念：（1） 不同 mRNA 的半衰期与 mRNA 相关的方式有所不同 (2) 各个 mRNA 的半衰期因响应而异 与 mRNA 功能相关的代谢条件。 因此，了解 mRNA 降解的机制对于理解如何降解变得非常重要 基因受到调节。 这种理解变得更加有价值 考虑到可以使用 mRNA 降解操作的许多情况 作为疾病治疗的手段。 参与者将包括研究 mRNA 的人员 原核生物和真核生物的衰变，使这次会议在所有生物中都是独一无二的 其他人为所有研究 mRNA 衰变的个人提供交流的机会 想法。 共有 36 名特邀演讲嘉宾，其中 10 名是女性， 其中助理教授或助理教授级杰出科学家7人 较少的。 会议的目标是聚集大约 120 人 会议环境允许信息通过主题演讲自由流动 演讲、平台展示、海报展示、圆桌讨论 和研讨会。 将创建一个摘要小册子来提供摘要 以及所有参与者的邮寄/电子邮件地址作为补充方式 交换信息。 涵盖的主题包括以下方面的最新进展 了解原核生物和真核生物的多功能核酸酶，如何 mRNA 定位和 mRNA 翻译影响 mRNA 半衰期、顺式作用 mRNA半衰期的序列和反式作用效应子，以及RNA作为 药物设计的工具和目标。