Training in Cellular, Biochemical and Molecular Sciences

细胞、生化和分子科学培训

• 批准号: 7849807
• 负责人: Lynne E Maquat
• 金额: $ 26.24万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7849807
• 关键词: Biochemical; Molecular; Science; Training

DESCRIPTION (provided by applicant): We describe the continuation of a pre-doctoral training program in Cellular, Biochemical and Molecular Biology (http://dbb.urmc.rochester.edu/T32/index.htm) with a core of interactive investigators in RNA, DNA, and protein biochemistry. The proposed training program capitalizes on (i) initiatives that expand research and education at the University of Rochester Medical Center (URMC) and College of Arts and Sciences (CAS), and (ii) enhanced educational choices resulting from the successful reorganization of Graduate Education in Biomedical Sciences (GEBS). Students are accepted into multidisciplinary "Clusters". They experience diverse research areas in their first year through courses, faculty research presentations, and laboratory rotations. They then choose a research advisor and degree program from a wide range of opportunities. We will maintain successful T32 initiatives: 1) provide one year of financial support for 6-8 students performing interdisciplinary research; 2) promote direct interactions between students and visiting seminar speakers; 3) offer practice in critical thinking in research science; 4) provide opportunities for off-site student travel to attend meetings, take courses, and work in outside laboratories; 5) counsel female and minority students to achieve career goals; 6) foster interactions among investigators and students in the areas of RNA, DNA, and protein biochemistry through course requirements and a yearly retreat; and 7) augment effective student recruiting through training-grant educational benefits. The University is benefiting from the recent appointments of a new President and Medical Center Director. Since funding of this T32, the URMC has not only filled two new research facilities (400,000 sq. ft.) and started new programs in Genetics, Biochemistry, Structural Biology, Virology, Signaling, Immunology, Neurobiology and Stem Cells, increasing the number of PIs from 150 to about 250, but also initiated a Strategic Plan with the construction of 500,000 sq. ft. of new labs. The Strategic Plan includes creation of five Innovative Science Programs that increase the opportunities for graduate training. Within this expanding infrastructure, our T32 continues to promote interactions among labs, flexibility in the choice of research mentors, and improved graduate recruiting. PUBLIC HEALTH RELEVANCE: Research funded by this T32 pertains to cellular, biochemical and molecular biology, with a focus on the structure and function of DNA, RNA and proteins. In view of the recent appreciation that most of genomic DNA is transcribed into RNA and that many genes encode more than one protein, research supported by this T32 will lend important insight into the mechanisms of cellular maintenance, growth and differentiation.

描述（由申请人提供）：我们用细胞，生化和分子生物学（http://dbb.urmc.rochester.edu/t32/index.htm）描述了延续博细胞，生化和分子生物学（http://dbb.urmc.rochester.ede）。拟议的培训计划利用了（i）倡议，该计划扩大了罗切斯特大学医学中心（URMC）和艺术与科学学院（CAS）的研究和教育，以及（ii）因生物医学科学（GEB）成功重组研究生教育而获得的增强的教育选择。学生被录取为多学科的“集群”。他们在第一年通过课程，教师研究演讲和实验室轮换体验了各种研究领域。然后，他们从各种机会中选择研究顾问和学位课程。我们将维持成功的T32计划：1）为6-8名从事跨学科研究的学生提供一年的财政支持； 2）促进学生与访问研讨会演讲者之间的直接互动； 3）提供研究科学批判性思维的实践； 4）提供场外学生旅行参加会议，参加课程和在外部实验室工作的机会； 5）咨询女学生和少数民族学生实现职业目标； 6）通过课程要求和年度撤退，在RNA，DNA和蛋白质生物化学领域的研究人员和学生之间的相互作用； 7）通过培训授予的教育福利来增强有效的学生招聘。该大学受益于新任总裁兼医疗中心主任的任命。自从本T32的资金资金以来，URMC不仅填补了两个新的研究设施（400,000平方英尺），并启动了遗传学，生物化学，结构生物学，病毒学，信号，免疫学，神经生物学和干细胞的新计划，从而将PIS的数量从150个增加到250个，但从250架开始了构建策略级别的SQ Q 00,000,000,000,000,000,000,000,000,000,000,000,000,0000 000年。战略计划包括创建五个创新的科学计划，以增加研究生培训的机会。在这一不断扩展的基础设施中，我们的T32继续促进实验室之间的互动，研究导师的选择灵活性以及改善了研究生招聘。 公共卫生相关性：该T32资助的研究与细胞，生化和分子生物学有关，重点是DNA，RNA和蛋白质的结构和功能。鉴于最近将大多数基因组DNA转录为RNA的欣赏，并且许多基因编码多个蛋白质，因此由该T32支持的研究将为细胞维持，生长和分化的机制提供重要的见解。