GORDON CONFERENCE ON RNA EDITING

RNA 编辑戈登会议

基本信息

批准号：
2849214
负责人：
Ronald B. Emeson
金额：
$ 2.09万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-03-20 至 1999-12-31
项目状态：
已结题

项目摘要

A Gordon Conference on RNA editing is planned for January 24-29, 1999 at the Doubletree hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA which results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and ser e to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences which are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard the cis-active regulatory elements and trans-acting factors mediating a number of editing processes are being evaluated at both the molecular and enetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being pursued at the level of evolution as well as the occurance of editing activities in different tissues and during development. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Finally, information about other forms of RNA processing is likely to have implications for understanding RNA editing mechanisms, and vice versa. Investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

计划于1999年1月24日至29日举行关于RNA编辑的戈登会议在加利福尼亚州文图拉的Doubletree酒店。 RNA编辑是 RNA的转录或后转录修饰，导致核苷酸的插入，缺失或取代。 RNA编辑可以因此，正确，扩展或多样化编码的信息相应的基因组序列，可以显着改变修改后的RNA的功能。例如，编辑事件哺乳动物中枢神经系统可以增加神经递质受体的表达和有效调节神经元信号通路。同样重要的是许多RNA编辑过程的细胞调节提供发育，组织特异性和代谢微调蛋白质功能和生化途径。我们对 RNA编辑及其生物学的分子机制发生的事件已达到关键阶段假设和实验方法对于重点是接下来的研究。有许多共同的问题和实验目标 RNA编辑的研究者尽管有生物多样其中进行编辑以及序列的明显差异修改了。对每次编辑的理解很重要系统是修改的RNA底物的基本描述通过这些过程。同样，普遍关注的问题关于机制，特异性，保真度和加工性 RNA编辑可以通过生化和分子生物学技术以及IN的发展体外编辑系统。在这方面，顺式主动调节介导许多编辑的元素和跨作用因素过程在分子和纤维水平上均已评估。了解这些因素在不同编辑之间的常见或不同特征级别系统是拟议的戈登研究的重要目标会议。还有其他编辑系统尚未提高到体外系统或直到最近才描述。戈登研究会议将促进信息和技术转移这将促进这些领域的发展。 RNA编辑调节的细胞和分子方面也是广泛地在进化水平以及发生在不同组织和期间的编辑活动发展。 RNA编辑的生物学意义是在拟议的会议的各个方面进行了反复出现的主题。最后，有关其他形式的RNA处理的信息可能会对理解RNA编辑机制有影响，并恶习 Versa。在RNA处理的其他领域工作的研究人员因此将参加适当的会议以刺激这些相关字段之间的交换。