GORDON CONFERENCE ON RNA EDITING

RNA 编辑戈登会议

• 批准号: 2849214
• 负责人: Ronald B. Emeson
• 金额: $ 2.09万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-03-20 至 1999-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2849214
• 关键词: meeting /conference /symposium; posttranscriptional RNA processing; travel

A Gordon Conference on RNA editing is planned for January 24-29, 1999 at the Doubletree hotel in Ventura, California. RNA editing is the co- or post-transcriptional modification of RNA which results in the insertion, deletion or substitution of nucleotides. RNA editing can therefore correct, extend or diversify the information encoded within the corresponding genomic sequence and can dramatically alter the function of the modified RNAs. For example, editing events within the mammalian central nervous system can increase the diversity of neurotransmitter receptor expression and ser e to effectively modulate neuronal signaling pathways. Equally significant is the cellular regulation of many of the RNA editing processes which provides for developmental, tissue-specific and metabolic fine tuning of protein function and biochemical pathways. Our understanding of molecular mechanisms underlying RNA editing and their biological occurrence has reached a critical stage where cross-fertilization of hypotheses and experimental approaches is essential for focus in the next decade of research. There are many common questions and experimental goals among investigators of RNA editing despite the diversity of organisms wherein editing occurs, and the apparent dissimilarities in sequences which are modified. Important to the understanding of every editing system is a basic description of the RNA substrates that are modified by these processes. Similarly, questions of general interest concerning the mechanism, specificity, fidelity and processivity of RNA editing can be addressed with a combination of biochemical and molecular biological techniques coupled with the development of in vitro editing systems. In this regard the cis-active regulatory elements and trans-acting factors mediating a number of editing processes are being evaluated at both the molecular and enetic level. Understanding the structure and function of these factors at the level of common or divergent features among the different editing systems is an important goal of the proposed Gordon Research Conference. Still other editing systems have yet to advance to in vitro systems or have been described only recently. The Gordon Research Conference will foster information and technology transfer which will promote developments in these areas. The cellular and molecular aspects of RNA editing regulation are also broadly being pursued at the level of evolution as well as the occurance of editing activities in different tissues and during development. The biological significance of RNA editing is a recurring theme throughout all aspects of the proposed conference. Finally, information about other forms of RNA processing is likely to have implications for understanding RNA editing mechanisms, and vice versa. Investigators working in other areas of RNA processing therefore will participate in appropriate sessions to stimulate exchange between these related fields.

RNA编辑戈登会议计划于1999年1月24日至29日举行 在加利福尼亚州文图拉的逸林酒店。 RNA编辑是 RNA 的共转录或转录后修饰，导致 核苷酸的插入、缺失或取代。 RNA编辑可以 因此纠正、扩展或多样化其中编码的信息 相应的基因组序列，并且可以显着改变 修饰后的RNA的功能。 例如，编辑事件 哺乳动物中枢神经系统可以增加 神经递质受体的表达及其有效作用 调节神经信号通路。 同样重要的是 许多 RNA 编辑过程的细胞调控 提供发育、组织特异性和代谢微调 蛋白质功能和生化途径。 我们的理解 RNA编辑的分子机制及其生物学 已经到了异花受精的关键阶段 假设和实验方法对于重点关注至关重要 下一个十年的研究。 其中存在许多常见问题和实验目标 尽管生物体具有多样性，但 RNA 编辑的研究人员 其中发生编辑，以及序列中明显的差异 哪些已修改。 对于理解每次编辑都很重要 系统是对被修饰的RNA底物的基本描述 通过这些过程。 同样，普遍关心的问题 关于机制、特异性、保真度和持续性 RNA 编辑可以通过生物化学和 分子生物学技术与生物技术的发展相结合 体外编辑系统。 在这方面，顺式主动监管 介导许多编辑的元素和反式作用因子 正在分子和遗传学水平上评估过程。 了解这些因素的结构和功能 不同编辑之间的共同或不同特征的水平 系统是戈登研究提议的一个重要目标 会议。 还有其他编辑系统尚未进步 体外系统或最近才被描述。 戈登 研究会议将促进信息和技术转让 这将促进这些领域的发展。 RNA 编辑调控的细胞和分子方面也 在进化层面以及 编辑活动在不同组织和过程中发生 发展。 RNA编辑的生物学意义是 贯穿拟议会议各个方面的反复出现的主题。 最后，有关其他形式的 RNA 加工的信息可能会 对于理解 RNA 编辑机制具有重要意义，反之亦然 反之亦然。 RNA 加工其他领域的研究人员 因此将参加适当的会议来刺激 这些相关领域之间的交流。