CODING OF BEHAVIORAL SEQUENCES IN THE BASAL GANGLIA

基底神经节行为序列的编码

• 批准号: 6393617
• 负责人: J Wayne Aldridge
• 金额: $ 29.48万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6393617
• 关键词: basal ganglia; dopamine agonists; ethology; experimental brain lesion; implant; injection /infusion; instinct; laboratory rat; neural information processing; psychomotor function; sensorimotor system; stereotaxic techniques; stimulus /response; substantia nigra; taste

DESCRIPTION (Adapted from applicant's abstract): The goal of this project is to understand the neuronal mechanisms of the basal ganglia that mediate sequences of behavior. Studies in humans indicate that sequence control, especially the control of movement sequences, may be a fundamental property of the basal ganglia. Motor disorders of the basal ganglia, such as Parkinson's disease and Huntington's disease, are associated with a profound loss of the ability to organize and execute sequences of movement. Furthermore, cognitive disorders of the basal ganglia such as the uncontrollable repetition of spoken words in Tourette's syndrome and the tormenting habits and thoughts of obsessive compulsive disorder suggest that sequential control mechanisms may be a fundamental property of the basal ganglia. In this project, the correlates and properties of single neurons related to instinctive, stereotyped sequences of behavioral actions will be studied. The long term goals of this project are designed to answer the following questions: How does the brain and in particular, the basal ganglia coordinate behavioral sequences? Are there basic principals for sequential organization? What are the computational properties of sequence-related neuronal assemblies in the basal ganglia? A key hypothesis to be tested in this study is that neuronal activity of a subset of cells in the basal ganglia will be related to movements within the context of rule-governed behavioral sequences and not related to these movements when they occur on their own or in irregular, less organized sets of movements. Previous experiments have shown that rats exhibit highly structured (i.e., syntactical) sequences of grooming bouts that follow strict rules for their temporal organization and that these syntactical sequences are disrupted by damage to the basal ganglia. Rats also execute comparable grooming movements in isolation and in other randomly organized patterns of movements. Our method will be to record and compare the activity of single neurons in rats during both syntactical and non-syntactical grooming sequences. It is anticipated that neuronal activity will be preferentially linked to movements in the context of stereotyped syntactical sequences. We will evaluate the anatomical location of neurons related to grooming movements to test the idea that the functional organization is related to the proposed cortico-striatal loops in the basal ganglia. We will evaluate the hypothesis that neostriatal neurons mediate sequences by modulating sensorimotor responsiveness. Finally, we will test the idea that Dl dopamine receptor activation will enhance neuronal activity related to sequential movements and the dopaminergic lesions will produce the opposite effect. It is hoped that new information about the neuronal network properties related to the organization of behavioral sequences will lead to a better understanding of the pathophysiology of basal ganglia diseases and eventually contribute to better treatments for these brain disorders.

描述（改编自申请人的摘要）：该项目的目标 是了解基底神经节介导的神经元机制 行为的序列。 人类研究表明序列控制， 尤其是运动顺序的控制，可能是一个基本属性 基底神经节。 基底节运动障碍，例如 帕金森病和亨廷顿病与深刻的疾病有关 丧失组织和执行一系列动作的能力。 此外，基底神经节的认知障碍，例如 图雷特综合症患者无法控制地重复口语 强迫症的折磨习惯和想法表明 顺序控制机制可能是基础的一个基本属性 神经节。 在这个项目中，单个神经元的相关性和属性 与本能的、刻板的行为动作序列相关的 研究过。 该项目的长期目标旨在回答 以下问题：大脑，特别是基础神经元如何 神经节协调行为序列？ 有没有基本原则 顺序组织？ 的计算特性是什么 基底神经节中序列相关的神经元组件？ 本研究要测试的一个关键假设是 基底神经节中的细胞子集将与基底神经节内的运动相关 规则控制的行为序列的背景，与这些无关 当它们单独发生或以不规则、组织性较差的方式发生时的运动 的运动。 先前的实验表明，老鼠表现出高度 接下来的结构化（即句法）梳理回合序列 它们的时间组织有严格的规则，并且这些句法 基底神经节受损会破坏序列。 老鼠也会执行 孤立和其他随机组织的类似梳理动作 运动模式。 我们的方法是记录并比较 大鼠单个神经元在句法和语法过程中的活动 非句法修饰序列。 预计神经元 活动将优先与以下背景下的运动相关联 刻板的句法序列。 我们将评估解剖位置 与梳理动作相关的神经元来测试这一想法 功能组织与拟议的皮质纹状体环有关 基底神经节。 我们将评估新纹状体神经元的假设 通过调节感觉运动反应来介导序列。 最后，我们 将测试 Dl 多巴胺受体激活会增强的想法 与顺序运动和多巴胺能相关的神经元活动 病变会产生相反的效果。 希望有新的信息 关于与组织相关的神经网络特性 行为序列将有助于更好地理解 基底神经节疾病的病理生理学并最终导致 更好地治疗这些大脑疾病。

项目成果

Implementation of action sequences by a neostriatal site: a lesion mapping study of grooming syntax.

新纹状体部位执行动作序列：梳理语法的病变映射研究。

• DOI: 10.1523/jneurosci.16-10-03444.1996
• 发表时间: 1996
• 期刊: The Journal of neuroscience : the official journal of the Society for Neuroscience.
• 作者: Cromwell,HC;Berridge,KC
• 通讯作者: Berridge,KC