CODING OF BEHAVIORAL SEQUENCES IN THE BASAL GANGLIA

基底神经节行为序列的编码

• 批准号: 2379679
• 负责人: J Wayne Aldridge
• 金额: $ 20.3万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-05-01 至 1998-07-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2379679
• 关键词: basal ganglia; ethology; experimental brain lesion; instinct; laboratory rat; neural information processing; psychomotor function; single cell analysis; stimulus /response; substantia nigra; taste

DESCRIPTION (Adapted from applicant's abstract): The goal of this project is to understand the neural mechanisms of the basal ganglia that mediate sequences of behavior. Motor disorders of the basal ganglia, such as Parkinson's and Huntington's disease, are associated with a profound loss of the ability to organize and execute sequences of movement. Furthermore, cognitive disorders of the basal ganglia such as Tourette's syndrome and obesessive compulsive disorder suggest that sequential control mechanisms may be a fundamental property of the basal ganglia. In this project, single neuron activity in the basal ganglia will be related to instinctive and learned behavior sequences to understand basal ganglia coordination of sequences, and to identify basic principles for sequential organization. Additional goals are to determine whether there are different neuronal substrates for learned and instinctive sequences and to determine the computational properties of sequence-related neuronal assemblies in the basal ganglia. A key hypothesis to be tested is that neuronal activity in the basal ganglia will be related to movements within the context of grooming sequences, and not related to these movements when they occur outside of these sequences. Single neurons will be recorded in rats during stereotyped sequential grooming and when components of movements are made in isolation or in other sequential patterns. Lastly, experiments will test the hypothesis that neostriatal neurons mediate sequences by modulating sensorimotor responsiveness. For those experiments, neuronal activity will be recorded after lesions of the substantia nigra, which disrupt sequential grooming, or by presenting cutaneous and taste stimuli during sequence execution.

描述（根据申请人的摘要改编）：目的 项目是要了解基底神经节的神经机制 中介行为序列。 基底神经节的运动障碍， 例如帕金森氏症和亨廷顿氏病，与 严重丧失组织和执行序列的能力 移动。 此外，基底神经节的认知障碍 如图雷特的综合症和肥胖的强迫症所表明的那样 顺序控制机制可能是基础的基本特性 神经节。 在这个项目中，基底神经节中的单个神经元活动将是 与本能和学习的行为序列有关 序列的基础神经节协调，并确定基本 顺序组织的原则。 其他目标是 确定学习学的神经元底物是否不同 和本能序列并确定计算属性 基底神经节中与序列相关的神经元组件的。 要测试的关键假设是基础的神经元活性 神经节将与修饰的背景下的运动有关 序列，与这些运动发生时无关 这些序列。 单个神经元将在老鼠中记录 定型的顺序修饰以及运动的组成部分 隔离或以其他顺序模式制成。 最后，实验 将检验以下假设：新纹状体神经元通过 调节感觉运动响应能力。 对于这些实验，神经元 活动将在黑质病变后记录，这将记录 破坏顺序修饰，或通过呈现皮肤和味觉刺激 在序列执行中。