AMINO ACIDS IN URINE, DIET & BP: INT'L POPULATION STUDY

尿液、饮食中的氨基酸

• 批准号: 6390850
• 负责人: Martha L Daviglus
• 金额: $ 19.73万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-15 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6390850
• 关键词: British Isles; China; Japan; United States; aminoacid analyzer; aminoacid metabolism; blood pressure; cardiovascular disorder epidemiology; clinical research; dietary aminoacid; dietary proteins; human data; hypertension; nutrition education; nutrition related tag; urinalysis

Little is known about population patterns of urinary amino acid (AA) excretion, relationships of dietary intake to urinary excretion of specific AA, and relationships of urinary AA to blood pressure (BP) of individuals. The general aim of this research is to make a major advance in this area, based on data from the INTERMAP Study, an international, cooperative, high- quality 17-sample population study of 4,706 men and women ages 40-59 in four countries (U.S., U.K., China, Japan). Analyses are to assess whether, independent of multiple possible confounding variables, there are significant relationships of dietary protein (total, animal, vegetable) and of dietary specific AA to 24-hour urinary excretion of total and individual AA and related compounds; systolic and diastolic BP of individuals are related to their 24-hour urinary excretion of taurine -- a possible marker of fish protein intake; 1-methylhistidine, 3- methylhistidine, histidine, lysine, anserine (1-methylhistidine- beta-alanine dipeptide) -- reflecting meat protein intake; arginine -- source in cells for nitric oxide (NO), implicated in vasodilation; other urinary amino acids. The study has already collected standardized comprehensive dietary and BP data on all individuals in its 17 samples (four 24-hour dietary recalls/person yielding data on 60+ nutrients, including 19 amino acids, two 24-hour urine specimens/person with data on Na, K, urea N, creatinine, volume; eight standardized SBP/DBP measurements/person; other data). Urinary concentrations of amino acids are to be analyzed chromatographically by high performance automatic amino acid analyzers in the INTERMAP Central Laboratory in Leuven, Belgium. Regression coefficients for AA-BP relationships are to be computed without and with correction for reliability (regression-dilution bias); sample-by- sample with pooling by country, region, and then overall; also by gender; for persons not on antihypertensive treatment; nonhypertensives; those free of a history of recent diet change; by education; et al., to evaluate comprehensively whether urinary AA excretion can add meaningfully to dietary data to give a better total understanding of relationships of dietary protein-AA to BP. These data can aid in developing better dietary recommendations for primary prevention of hypertension, and to shift population BP distributions downward to avoid excess risks associated with present levels, generally above optimal.

关于尿氨基酸（AA）排泄的种群模式，饮食摄入与特定AA的尿液排泄的关系以及尿液与血压（BP）的关系知之甚少。 这项研究的总体目的是根据Intermap研究的数据，这是一项国际，合作，高质量的17个样本人口研究，对四个国家（美国，英国，中国，日本）进行了4,706名男性40-59岁的男子和女性。 分析是为了评估是否与多个可能的混杂变量无关，饮食蛋白（总，动物，蔬菜）和饮食特异性AA与总AA的24小时尿液排泄之间存在显着关系；个体的收缩压和舒张压与牛磺酸的24小时尿排泄有关，这可能是鱼类蛋白摄入的标志物； 1-甲基组织，3-甲基组织，组氨酸，赖氨酸，anserine（1-甲基组织 - β-丙氨酸二肽） - 反映肉类蛋白摄入量；精氨酸 - 一氧化氮（NO）的细胞来源，与血管舒张有关；其他尿氨基酸。 这项研究已经收集了17个样本中所有个体的标准化综合饮食和BP数据（4个24小时饮食召回/人，他们产生了60多种营养素的数据，包括19种氨基酸，两个24小时的尿液标本/患者，其中有NA，K，k，urea n，urea n，creatinine，creatinine，卷，八个标准化的SBP/DBP测量；其他数据）。 氨基酸的尿液浓度应通过比利时鲁南的地图中央实验室中的高性能自动氨基酸分析仪在色谱上进行分析。 AA-BP关系的回归系数应在没有并纠正可靠性的情况下计算（回归稀释偏差）；按样本样本，逐国家，地区，然后是总体样本；同样是性别；对于不进行降压治疗的人；非量化剂；那些没有最近饮食变化史的人；通过教育；等，全面评估尿液AA排泄是否可以有意义地增加饮食数据，以更好地了解饮食蛋白AA与BP的关系。 这些数据可以帮助制定更好的饮食建议，以初级预防高血压，并向下移动人口BP分布，以避免与当前水平相关的过多风险，通常高于最佳。