Sleep and Cardiovascular Health

睡眠与心血管健康

• 批准号: 7596120
• 负责人: Martha L Daviglus
• 金额: $ 59.11万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7596120
• 关键词: Abbreviations; Accounting; Adult; Age; Ancillary Study; Ankle; Antihypertensive Agents; Atherosclerosis; Blood Pressure; C-reactive protein; Calcium; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Chicago; Childhood; Cholesterol; Chronic; Clinical; Cognitive; Coronary artery; Coronary heart disease; Data; Detection; Development; Diabetes Mellitus; Disease; Elderly; Funding; Glossary; Glucose; Goals; Health; Health Status; Heart; Hour; Hypertension; Individual; Industry; Laboratories; Lead; Life; Life Expectancy; Link; Lipids; Literature; Measures; Medical; Medical History; Metabolic; Morbidity - disease rate; Myocardial Infarction; Obesity; Obstructive Sleep Apnea; Outcome; Parents; Participant; Performance; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Plasma; Population; Positioning Attribute; Prevalence; Prevention; Preventive; Principal Investigator; Psychomotor Performance; Quality of life; Questionnaires; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Serum; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Smoke; Smoking; Societies; Stroke; Testing; Time; actigraphy; age related; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; emerging adult; functional status; high risk; hypercholesterolemia; improved; improved functioning; indexing; inflammatory marker; middle age; neuropsychological; parent grant; population based; public health relevance; sleep onset; trait; treatment strategy

DESCRIPTION (provided by investigator): With increase in life expectancy, there has also been a parallel increase in chronic co- morbidities that impair functional status and quality of life in older age. Converging lines of evidence link sleep quality and quantity with cardiovascular health. A considerable body of literature demonstrates that short sleep duration (<7 hours) is associated with increased levels of cardiovascular disease (CVD) risk factors including obesity, hypertension, and diabetes in population-based studies. Further, evidence suggests that poor health status also increases the prevalence of sleep disorders. This relationship may be particularly prominent in older adults, who often have the burden of both sleep disturbances and medical co-morbidities. The proposed study is uniquely able to examine these matters cross-sectionally (in older people), and prospectively -- in particular the relation of early adult CVD risk factor levels to sleep quality and sleep disorders in older age by examining a pre-assembled cohort of the Chicago Heart Association Study with CVD risk status characterized approximately 40 years ago. The specific aims are to: a) determine the relationship between CVD risk status, especially low risk (LR), at ages 25-44 with subsequent sleep quality, levels of daytime sleepiness, and sleep apnea in older age (65-79); b) assess whether change in risk factor status from ages 25-44 to older age relates to sleep quality, daytime sleepiness, sleep apnea, neuropsychological performance, and cardiovascular health status in older age, and c) explore relationships among current CVD risk factors, CVD, sleep quality, sleepiness, sleep apnea, daytime neuropsychological performance, and other variables in older age. Both objective and subjective measures of sleep are to be used in conjunction with measures of CVD risk (BMI, blood pressure, lipids, glucose, smoking, C-reactive protein), clinical and subclinical CVD (coronary artery calcium, ankle brachial index), obtained by the recently funded parent grant (R01 HL081141; Principal Investigator, Martha L. Daviglus). 1,380 participants, identified at baseline as LR for CVD or not LR for CVD, are to undergo subjective and objective sleep measures (questionnaires and actigraphy). A subset of 150 participants (50 LR who do not become high risk by older age, 50 LR who became high risk, and 50 high risk at baseline who remain so in older age) are to attend the laboratory for more detailed physiological studies of sleep. By leveraging resources of the parent grant, this ancillary study is uniquely positioned to study these multiple relationships among CVD risk at ages 25-44, sleep variables, and other traits in older age. Results of this study can have important implications theoretical and practical, e.g., for prevention and treatment of sleep disorders and CVD in later life. PUBLIC HEALTH RELEVANCE: Recent studies indicate a strong link between sleep and sleep disorders, such as sleep apnea with cardiovascular health. A considerable body of evidence clearly demonstrates that short sleep duration disrupts metabolic and cardiovascular function and has been associated with increased levels of cardiovascular risk factors, such as C-reactive protein, BMI, blood pressure, lipids, coronary artery calcium, ankle brachial index, glucose, and smoking. Therefore, an improved understanding of the relationship between sleep and cardiovascular health will lead to preventive approaches and treatment strategies to improve function, health, and overall quality of life in the growing population of older adults.

描述（由研究者提供）：随着预期寿命的延长，损害老年功能状态和生活质量的慢性合并症也随之增加。越来越多的证据将睡眠质量和数量与心血管健康联系起来。大量文献表明，基于人群的研究表明，睡眠时间短（<7 小时）与心血管疾病 (CVD) 危险因素（包括肥胖、高血压和糖尿病）水平升高相关。此外，有证据表明，健康状况不佳也会增加睡眠障碍的患病率。这种关系在老年人中尤其突出，他们经常承受睡眠障碍和合并症的负担。拟议的研究独特地能够横向（针对老年人）和前瞻性地研究这些问题，特别是通过检查预先组装的队列，研究早期成人 CVD 危险因素水平与老年人睡眠质量和睡眠障碍的关系芝加哥心脏协会研究大约 40 年前对 CVD 风险状态进行了表征。具体目标是： a) 确定 25-44 岁的 CVD 风险状态，特别是低风险 (LR) 与随后的睡眠质量、日间嗜睡水平和老年 (65-79) 睡眠呼吸暂停之间的关系； b) 评估从 25-44 岁到老年的危险因素状态的变化是否与老年人的睡眠质量、日间嗜睡、睡眠呼吸暂停、神经心理表现和心血管健康状况有关，以及 c) 探索当前 CVD 危险因素之间的关系，心血管疾病、睡眠质量、困倦、睡眠呼吸暂停、日间神经心理学表现以及其他老年变量。睡眠的客观和主观测量均应与 CVD 风险测量（BMI、血压、血脂、血糖、吸烟、C 反应蛋白）、临床和亚临床 CVD（冠状动脉钙、踝臂指数）、由最近资助的家长资助（R01 HL081141；首席研究员 Martha L. Daviglus）获得。 1,380 名参与者在基线时被确定为 CVD LR 或非 CVD LR，将接受主观和客观睡眠测量（问卷和体动记录仪）。 150 名参与者的子集（50 名 LR 不会随着年龄的增长而成为高风险，50 名 LR 会成为高风险，50 名基线时的高风险在老年后仍保持高风险）将前往实验室进行更详细的睡眠生理研究。通过利用家长资助的资源，这项辅助研究具有独特的优势，可以研究 25-44 岁的 CVD 风险、睡眠变量和老年特征之间的多重关系。这项研究的结果可能具有重要的理论和实践意义，例如，对于晚年睡眠障碍和心血管疾病的预防和治疗。公共健康相关性：最近的研究表明，睡眠和睡眠障碍（例如睡眠呼吸暂停与心血管健康）之间存在密切联系。大量证据清楚地表明，睡眠时间短会扰乱代谢和心血管功能，并与心血管危险因素水平升高相关，如 C 反应蛋白、BMI、血压、血脂、冠状动脉钙、踝肱指数、葡萄糖和吸烟。因此，更好地了解睡眠与心血管健康之间的关系将有助于制定预防方法和治疗策略，以改善不断增长的老年人群的功能、健康和整体生活质量。