Sleep and Cardiovascular Health

睡眠与心血管健康

• 批准号: 7596120
• 负责人: Martha L Daviglus
• 金额: $ 59.11万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2013-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7596120
• 关键词: Abbreviations; Accounting; Adult; Age; Ancillary Study; Ankle; Antihypertensive Agents; Atherosclerosis; Blood Pressure; C-reactive protein; Calcium; Cardiovascular Diseases; Cardiovascular Physiology; Cardiovascular system; Chicago; Childhood; Cholesterol; Chronic; Clinical; Cognitive; Coronary artery; Coronary heart disease; Data; Detection; Development; Diabetes Mellitus; Disease; Elderly; Funding; Glossary; Glucose; Goals; Health; Health Status; Heart; Hour; Hypertension; Individual; Industry; Laboratories; Lead; Life; Life Expectancy; Link; Lipids; Literature; Measures; Medical; Medical History; Metabolic; Morbidity - disease rate; Myocardial Infarction; Obesity; Obstructive Sleep Apnea; Outcome; Parents; Participant; Performance; Persons; Pharmaceutical Preparations; Physical Function; Physiological; Plasma; Population; Positioning Attribute; Prevalence; Prevention; Preventive; Principal Investigator; Psychomotor Performance; Quality of life; Questionnaires; Research Personnel; Resources; Risk; Risk Factors; Role; Sampling; Serum; Sleep; Sleep Apnea Syndromes; Sleep Disorders; Sleep disturbances; Smoke; Smoking; Societies; Stroke; Testing; Time; actigraphy; age related; base; cardiovascular disorder risk; cardiovascular risk factor; cohort; emerging adult; functional status; high risk; hypercholesterolemia; improved; improved functioning; indexing; inflammatory marker; middle age; neuropsychological; parent grant; population based; public health relevance; sleep onset; trait; treatment strategy

DESCRIPTION (provided by investigator): With increase in life expectancy, there has also been a parallel increase in chronic co- morbidities that impair functional status and quality of life in older age. Converging lines of evidence link sleep quality and quantity with cardiovascular health. A considerable body of literature demonstrates that short sleep duration (<7 hours) is associated with increased levels of cardiovascular disease (CVD) risk factors including obesity, hypertension, and diabetes in population-based studies. Further, evidence suggests that poor health status also increases the prevalence of sleep disorders. This relationship may be particularly prominent in older adults, who often have the burden of both sleep disturbances and medical co-morbidities. The proposed study is uniquely able to examine these matters cross-sectionally (in older people), and prospectively -- in particular the relation of early adult CVD risk factor levels to sleep quality and sleep disorders in older age by examining a pre-assembled cohort of the Chicago Heart Association Study with CVD risk status characterized approximately 40 years ago. The specific aims are to: a) determine the relationship between CVD risk status, especially low risk (LR), at ages 25-44 with subsequent sleep quality, levels of daytime sleepiness, and sleep apnea in older age (65-79); b) assess whether change in risk factor status from ages 25-44 to older age relates to sleep quality, daytime sleepiness, sleep apnea, neuropsychological performance, and cardiovascular health status in older age, and c) explore relationships among current CVD risk factors, CVD, sleep quality, sleepiness, sleep apnea, daytime neuropsychological performance, and other variables in older age. Both objective and subjective measures of sleep are to be used in conjunction with measures of CVD risk (BMI, blood pressure, lipids, glucose, smoking, C-reactive protein), clinical and subclinical CVD (coronary artery calcium, ankle brachial index), obtained by the recently funded parent grant (R01 HL081141; Principal Investigator, Martha L. Daviglus). 1,380 participants, identified at baseline as LR for CVD or not LR for CVD, are to undergo subjective and objective sleep measures (questionnaires and actigraphy). A subset of 150 participants (50 LR who do not become high risk by older age, 50 LR who became high risk, and 50 high risk at baseline who remain so in older age) are to attend the laboratory for more detailed physiological studies of sleep. By leveraging resources of the parent grant, this ancillary study is uniquely positioned to study these multiple relationships among CVD risk at ages 25-44, sleep variables, and other traits in older age. Results of this study can have important implications theoretical and practical, e.g., for prevention and treatment of sleep disorders and CVD in later life. PUBLIC HEALTH RELEVANCE: Recent studies indicate a strong link between sleep and sleep disorders, such as sleep apnea with cardiovascular health. A considerable body of evidence clearly demonstrates that short sleep duration disrupts metabolic and cardiovascular function and has been associated with increased levels of cardiovascular risk factors, such as C-reactive protein, BMI, blood pressure, lipids, coronary artery calcium, ankle brachial index, glucose, and smoking. Therefore, an improved understanding of the relationship between sleep and cardiovascular health will lead to preventive approaches and treatment strategies to improve function, health, and overall quality of life in the growing population of older adults.

描述（调查员提供）：随着预期寿命的增加，慢性共同病毒的增加，损害了老年时代的功能状况和生活质量。融合的证据线将睡眠质量和数量与心血管健康联系起来。大量文献表明，短睡眠持续时间（<7小时）与心血管疾病（CVD）危险因素的水平增加有关，包括肥胖，高血压和糖尿病。此外，有证据表明，健康状况差也会增加睡眠障碍的患病率。这种关系在老年人中可能尤其突出，他们经常承担睡眠障碍和医疗合并症的负担。拟议的研究具有独特的能力，能够在横截面上（在老年人中）进行检查 - 特别是成年成年CVD危险因素水平与睡眠质量和睡眠障碍的关系，通过检查芝加哥心脏协会的预组件研究与CVD风险状态的预组装同类，大约40年前的特征。具体目的是：a）确定25-44岁的CVD风险状况，尤其是低风险（LR）之间的关系，随后的睡眠质量，白天嗜睡水平和年龄较大的睡眠呼吸暂停之间的关系（65-79）； b）评估危险因素状况从25-44岁到老年的变化是否与年龄较大的睡眠质量，白天嗜睡，睡眠呼吸暂停，神经心理学表现和心血管健康状况有关，以及C）探索当前CVD风险因素，CVD，CVD，睡眠质量，睡眠呼吸暂停，睡眠呼吸暂停，白天神经心理学表现的关系客观和主观的睡眠措施均应与CVD风险（BMI，血压，脂质，脂质，葡萄糖，吸烟，C-反应蛋白），临床和亚临床CVD（冠状动脉钙，踝关节臂指数）一起使用，并获得了最近资助的父级助理（R0141）。 Daviglus）。 1,380名参与者，在基线为CVD或非LR的LR确定为CVD，将接受主观和客观的睡眠度量（问卷和行为语义）。 150名参与者的子集（50名LR在年龄较大时不会成为高风险，50名LR成为高风险，而在基线保持年龄的50个高风险）将参加实验室，以进行更详细的睡眠生理研究。通过利用父母赠款的资源，这项辅助研究的独特位置可以研究25-44岁的CVD风险之间的这些多重关系，睡眠变量和其他年龄的其他特征。这项研究的结果可能具有理论上的重要含义，例如，在以后的生活中预防和治疗睡眠障碍和CVD。公共卫生相关性：最近的研究表明睡眠和睡眠障碍之间有着密切的联系，例如睡眠呼吸暂停与心血管健康。大量证据清楚地表明，短睡眠持续时间会破坏代谢和心血管功能，并且与心血管危险因素的水平增加有关，例如C反应蛋白，BMI，血压，血压，脂质，冠状动脉钙，冠状动脉钙，脚踝臂式凝乳，gl素，gllucose和吸烟。因此，对睡眠与心血管健康之间的关系的改进理解将导致预防方法和治疗策略，以改善不断增长的老年人人群的功能，健康和整体生活质量。