Nursing Inquiry: Stress & Immune Response with Battering

护理询问：压力

• 批准号: 6366194
• 负责人: Stephanie J Woods
• 金额: $ 10.06万
• 依托单位: UNIVERSITY OF AKRON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6366194
• 关键词: behavioral /social science research tag; child abuse; cortisol; early experience; female; human subject; leukocyte count; nursing research; patient oriented research; posttraumatic stress disorder; psychological models; psychoneuroimmunology; spouse abuse; violence; women's health

DESCRIPTION: (provided by applicant) Research with clinical- and population-based samples has shown that at least 60 percent of battered women experience posttraumatic stress disorder (PTSD). While changes in cortisol levels, immune status, and long-term health consequences associated with PTSD have been studied in several trauma survivor groups, there has been little such research with women in general, and battered women in particular. Additionally, there is a paucity of literature identifying specific predictors of PTSD symptoms in battered women. The purpose of this study is to examine the relationship between and among intimate partner violence, trauma history, PTSD symptomatology, cortisol levels, and immune status in battered women. The specific aims are to: 1) identify which empirical indicators of intimate partner violence (actual physical violence, emotional abuse, sexual violence, risk of homicide, threats of violence, and length of abusive relationship) are more predictive of PTSD symptoms in battered women; 2) examine the relative effects of childhood maltreatment and adult trauma history on PTSD symptoms in battered women; 3) examine childhood maltreatment as a moderator of PTSD symptoms in battered women; 4) describe immune status via leukocyte count, lymphocyte subset counts (CD4 cell, CD8 cell, B-cell, and natural killer cell), CD4:CD8 ratio, number of viral illnesses the past 6 months, and IgA levels in battered women; 5) examine the relationship between PTSD symptoms and salivary cortisol levels in battered women; and 6) examine the relationship between intimate partner violence, trauma history, PTSD symptoms, cortisol levels, and immune status in battered women. The theoretical interrelationships among the model constructs delineated in the specific aims will be examined in a sample of 135 battered women from shelters and the community. The soft modeling, or Least Variable Path Analysis with Partial Least Squares, approach to structural equation modeling and multiple regression will be used to test the specified relationships among the model constructs in the proposed model. The proposal also aims to enhance the development of the investigator as a nurse scientist with the advanced clinical and statistical skills needed to investigate the complex interrelationships between physiologic and psychosocial responses to intimate violence. The investigator?s long-term objectives are to develop, refine, and/or expand holistic interventions with the goal of delaying the onset and progression of disease in persons experiencing chronic stress as a result of violence or trauma.

描述：（由申请人提供）临床和 基于人群的样本表明，至少有60％的受虐妇女 经历创伤后应激障碍（PTSD）。而皮质醇的变化 与PTSD相关的水平，免疫状态和长期健康后果 已经在几个创伤幸存者群体中进行了研究，几乎没有这样的 与一般妇女进行研究，尤其是殴打妇女。此外， 识别PTSD的特定预测指标的文献很少 受虐妇女的症状。这项研究的目的是检查 亲密伴侣暴力，创伤历史，PTSD之间的关系 受虐妇女的症状学，皮质醇水平和免疫状态。这 具体目的是：1）确定哪些亲密的经验指标 伴侣暴力（实际的身体暴力，情绪虐待，性暴力，性暴力， 杀人罪的风险，暴力威胁和虐待关系的长度）是 更可预测受虐妇女的PTSD症状； 2）检查亲戚 儿童虐待和成人创伤史对PTSD症状的影响 受虐的妇女； 3）检查儿童虐待作为PTSD的主持人 受虐妇女的症状； 4）通过白细胞计数描述免疫状态， 淋巴细胞子集数（CD4细胞，CD8细胞，B细胞和天然杀伤细胞）， CD4：CD8比率，过去6个月的病毒疾病数量，IgA水平 受虐的妇女； 5）检查PTSD症状与唾液之间的关系 受虐妇女的皮质醇水平； 6）检查 亲密的伴侣暴力，创伤病史，PTSD症状，皮质醇水平和 受虐妇女的免疫状态。 模型之间的理论相互关系构建了 将在135名受虐妇女的样本中检查具体目标 和社区。软建模或最小可变路径分析 部分最小二乘，结构方程建模的方法和多个 回归将用于测试模型之间的指定关系 拟议模型中的构造。 该提案还旨在增强研究人员的发展 护士科学家具有所需的高级临床和统计技能 研究生理与社会心理之间的复杂相互关系 对亲密暴力的回应。调查员的长期目标是 开发，完善和/或扩展整体干预措施，以延迟 经历慢性压力的人的疾病的发作和进展为 暴力或创伤的结​​果。