PTSD, Cortisol, Immune Function with Battering Over Time

创伤后应激障碍 (PTSD)、皮质醇、免疫功能随时间的推移而受到打击

• 批准号: 7122979
• 负责人: Stephanie J Woods
• 金额: $ 44.35万
• 依托单位: UNIVERSITY OF AKRON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7122979
• 关键词: behavior prediction; biomarker; child abuse; circadian rhythms; clinical research; cortisol; epidemiology; female; hormone metabolism; human subject; immune response; longitudinal human study; mathematical model; posttraumatic stress disorder; psychological adaptation; salivary disorder; spouse abuse; women' s health

DESCRIPTION (provided by applicant): The devastating physical and emotional effects associated with intimate partner violence (IPV) affect nearly 1.2 million women in the United States yearly. The first assault is only the beginning of the terror, injuries, and desperation that can continue through a woman's life. Knowledge regarding the dynamic interplay among the physiological and psychological factors affecting the health of women who have experienced violence and trauma is limited, particularly as it relates to repeated traumatic experiences. Most studies of trauma survivor groups are conducted cross-sectionally, yielding much information, but this methodology provides only a single observation in time. Little is known in nursing or other disciplines about how the impact of IPV might affect health over time. The purpose of this study is to examine relationships among IPV, childhood maltreatment, resilience, and posttraumatic stress disorder (PTSD) on health outcomes, including self-report physical health, diurnal adrenocortical hormones, and immune function in 156 battered women from shelters and the community over 24-months. A predictive-explanatory design will be employed to test a model of these relationships and address three research objectives: 1) to test the cross-sectional fit of the model and identify possible mediating and moderating paths, 2) to longitudinally examine patterns of relationships among diurnal adrenocortical hormones, immune function and PTSD, and 3) to longitudinally test the fit of the full model. Structural equation modeling (SEM) will be used to model the cross-sectional and longitudinal relationships between model constructs and growth curve modeling will be used to examine trajectories of change in PTSD, diurnal adrenocortical hormones, and immune function over 24-months. Exploratory analyses will be used to identify predictors of individual patterns of change. This study will increase knowledge regarding the relationships between psychosocial and physiologic responses to trauma and their impact on women's health over time. Findings will provide a theoretical foundation upon which to develop nursing interventions directed towards the prevention and reduction of long-term physical and mental health consequences of IPV.

描述（由申请人提供）：与亲密伴侣暴力（IPV）相关的毁灭性的身体和情感影响每年影响近120万妇女。第一次攻击只是恐怖，伤害和绝望的开始，可以延续一个女人的生活。关于影响经历暴力和创伤的妇女健康的生理和心理因素之间动态相互作用的知识是有限的，尤其是与反复的创伤经历有关。大多数对创伤幸存者组的研究都是在横截面进行的，提供了很多信息，但是该方法仅提供了一个时间观察。关于IPV的影响可能会随着时间的推移影响健康，在护理或其他学科中知之甚少。这项研究的目的是检查IPV，儿童虐待，韧性和创伤后应激障碍（PTSD）之间关于健康结果的关系，包括自我报告的身体健康，昼夜性肾上腺皮质激素以及156名受害妇女的免疫功能，来自庇护所和24个月超过24个月的社区。将采用预测性解释性设计来测试这些关系的模型，并解决三个研究目标：1）测试模型的横截面拟合，并确定可能的中介和调节路径，2）纵向研究纵向性激素之间的关系模式，并进行了较长的模型，并进行了较长的模型。结构方程模型（SEM）将用于模拟模型构建体和生长曲线模型之间的横截面和纵向关系，用于检查PTSD，昼夜diurnal的肾上腺皮质激素的变化轨迹以及24个月以上的免疫功能。探索性分析将用于确定各个变化模式的预测指标。这项研究将增加有关心理社会和生理反应之间对创伤的关系的知识及其对妇女健康的影响。调查结果将为开发用于预防和减少IPV身心健康后果的护理干预措施的理论基础。