GENETICS OF LOW DOSE ETHANOL EFFECTS

低剂量乙醇效应的遗传学

• 批准号: 6371635
• 负责人: RICHARD A DEITRICH
• 金额: $ 15.1万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6371635
• 关键词: alcoholism /alcohol abuse; animal colony; behavioral /social science research tag; behavioral genetics; disease /disorder model; ethanol; genetic susceptibility; laboratory rat; neurogenetics; neuropharmacology; quantitative trait loci

Among the risk factors for alcoholism in humans is a low initial sensitivity and/or a rapid development of tolerance to ethanol. These behavioral reactions can be modeled in animals. One such model is Alcohol Tolerant (AT) and Alcohol Non-Tolerant (ANT) lines of rats that were selectively bred for genetic tolerance to a low, ataxic dose of ethanol. These animals have been transferred to the University of Colorado and we will compare the genetic characteristics of these animals with those that we have selectively bred to genetic tolerance to a high, anesthestizing dose of ethanol, the High Alcohol Sensitive (HAS) and Low Alcohol Sensitive (LAS) rats. We will locate and compare Quantitiative Trait Loci in these two groups of animals as well as carry out comparisons on the development of tolerance to a number of behavioral effects of ethanol. In addition we will make the AT and ANT rats available to researchers in this country and abroad for their studies. The data generated along with similar data from studies in mice will be useful in the search for the genes that underlie the risk factors for alcoholism in humans.

在人类中酒精中毒的风险因素中，最初的敏感性和/或对乙醇耐受性的快速发展。这些行为反应可以在动物中建模。一种这样的模型是耐酒精（AT）和酒精非耐受性（ANT）的大鼠，它们被选择性地繁殖为遗传耐受性，可对低调剂量的乙醇。这些动物已被转移到科罗拉多大学，我们将将这些动物的遗传特征与我们有选择地繁殖到遗传耐受性的那些遗传特征，以高于乙醇的高剂量，高酒精敏感（HAS）和低酒精敏感（LAS）大鼠。我们将在这两组动物中找到和比较定量性状基因座，并对乙醇多种行为影响的耐受性的发展进行比较。此外，我们将使该国和国外的研究人员可以使用AT和蚂蚁大鼠进行研究。在小鼠中产生的数据以及来自研究的类似数据将在搜索人类酒精中毒的基因的搜索中很有用。