GENETICS OF LOW DOSE ETHANOL EFFECTS

低剂量乙醇效应的遗传学

• 批准号: 6089010
• 负责人: RICHARD A DEITRICH
• 金额: $ 21.12万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6089010
• 关键词: alcoholism /alcohol abuse; animal colony; behavioral /social science research tag; behavioral genetics; disease /disorder model; ethanol; genetic susceptibility; laboratory rat; neurogenetics; neuropharmacology; quantitative trait loci

Among the risk factors for alcoholism in humans is a low initial sensitivity and/or a rapid development of tolerance to ethanol. These behavioral reactions can be modeled in animals. One such model is Alcohol Tolerant (AT) and Alcohol Non-Tolerant (ANT) lines of rats that were selectively bred for genetic tolerance to a low, ataxic dose of ethanol. These animals have been transferred to the University of Colorado and we will compare the genetic characteristics of these animals with those that we have selectively bred to genetic tolerance to a high, anesthestizing dose of ethanol, the High Alcohol Sensitive (HAS) and Low Alcohol Sensitive (LAS) rats. We will locate and compare Quantitiative Trait Loci in these two groups of animals as well as carry out comparisons on the development of tolerance to a number of behavioral effects of ethanol. In addition we will make the AT and ANT rats available to researchers in this country and abroad for their studies. The data generated along with similar data from studies in mice will be useful in the search for the genes that underlie the risk factors for alcoholism in humans.

人类酗酒的危险因素之一是最初的敏感性较低和/或对乙醇的耐受性迅速发展。这些行为反应可以在动物身上进行建模。其中一种模型是耐酒精（AT）和不耐酒精（ANT）大鼠品系，这些大鼠经过选择性培育，具有对低共济失调剂量乙醇的遗传耐受性。这些动物已转移到科罗拉多大学，我们将把这些动物的遗传特征与我们选择性培育的动物进行比较，以对高麻醉剂量的乙醇、高酒精敏感型 (HAS) 和低酒精敏感型进行遗传耐受。 （LAS）大鼠。我们将定位并比较这两组动物的数量性状基因座，并对乙醇的一些行为影响的耐受性的发展进行比较。此外，我们还将向国内外研究人员提供AT和ANT大鼠进行研究。产生的数据以及小鼠研究中的类似数据将有助于寻找人类酗酒危险因素的基因。