CANDIDA SECRETED ASPARTIC PROTEASES AS DRUG TARGETS

念珠菌分泌的天冬氨酸蛋白酶作为药物靶标

• 批准号: 6163937
• 负责人: ALICE M. CLARK
• 金额: $ 26.84万
• 依托单位: UNIVERSITY OF MISSISSIPPI
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-01 至 2002-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6163937
• 关键词: Candida; antifungal agents; aspartic endopeptidases; drug design /synthesis /production; drug screening /evaluation; plant extracts

DESCRIPTION (Adapted from the Investigator's Abstract): This proposal addresses inhibitors of Candida spp aspartic proteases as antifungal agents. The aims are to develop rapid screening procedures of Candida proteases from plant sources, evaluate plant extracts for protease inhibition, isolate and structurally characterize inhibitors from active plant extracts, characterize the mechanisms of inhibition of purified active natural products and design and synthesize second-generation inhibitors.

描述（改编自研究者的摘要）：本提案 将念珠菌属天冬氨酸蛋白酶抑制剂用作抗真菌药物 代理。 目的是开发念珠菌快速筛查程序 植物来源的蛋白酶，评估植物提取物的蛋白酶 抑制、分离和结构表征活性抑制剂 植物提取物，表征纯化的抑制机制 活性天然产物第二代的设计合成 抑制剂。