Genomics Core

基因组学核心

• 批准号: 8935694
• 负责人: Eugene Wei-Ming Yeo
• 金额: $ 14.34万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8935694
• 关键词: Astrocytes; Autistic Disorder; Awareness; Biological; Biological Assay; Cells; Cellular Assay; Classification; Clustered Regularly Interspaced Short Palindromic Repeats; Collaborations; Communities; Consult; Custom; Data; Development; Engineering; Floor; Gene Expression; Gene Expression Profile; Gene Expression Profiling; Genes; Genomics; Housing; Human; Individual; Institutes; Institution; Karyotype determination procedure; Knowledge; Laboratories; Libraries; Measures; Medicine; Methods; Molecular Profiling; Neuroglia; Neurons; Pattern; Population; Preparation; Procedures; Promoter Regions; Protocols documentation; Quality Control; RNA; Regenerative Medicine; Research Support; Running; Services; Stem cells; System; Techniques; Technology; Training; Universities; Validation; Variant; base; biosignature; density; design; digital; embryonic stem cell; empowered; exome; genome analysis; genome editing; induced pluripotent stem cell; innovation; member; new technology; next generation sequencing; novel strategies; pre-clinical; research study; single cell analysis; transcriptome sequencing

Project Summary The COPACABANA Genomics Core will provide innovative, reliable and transparent services using innovative new technologies to enable the Projects to accomplish their individual and overall aims and to disseminate new workflows and assays that are developed by Projects to the wider community. Specifically, the Genomics Core will enable Projects 1, 2 and 3 in advancing the quality control metrics for validating genome-editing technologies, identify robust RNA signatures for classification of cortical layer V neurons and astroglial cells and to provide high-quality single-cell RNA-seq data and disseminate all these analyses to the community.

项目摘要 Copacabana Genomics Core将使用创新提供创新，可靠和透明的服务 新技术使项目能够完成其个人和整体目标并传播新的目标 项目为更广泛的社区开发的工作流和测定。具体而言，基因组学核心 将启用项目1、2和3，以推进质量控制指标，以验证基因组编辑 技术，确定可鲁棒的RNA签名，以分类皮层V神经元和星形胶质细胞的分类 并提供高质量的单细胞RNA-seq数据并将所有这些分析传播给社区。