THE MOTIVATIONAL CONTROL OF ALCOHOL-SEEKING BEHAVIOR

酗酒行为的动机控制

• 批准号: 6509122
• 负责人: Suzette V Glasner-Edwards
• 金额: $ 0.15万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-06-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6509122
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; arousal; behavior prediction; behavior test; behavioral /social science research tag; biological models; choice; conditioning; craving; cues; disease /disorder model; ethanol; goal oriented behavior; laboratory rat; motivation; reinforcer; substance abuse related behavior

Studies of the role of motivational processes in drug abuse have yet to address the relationship between the motivational processes that control alcohol-seeking behavior and those that control the pursuit of natural rewards, such as food or fluids. Although little direct evidence exists to conclude that the motivational processes that control instrumental rewards control alcohol-seeking behavior, there is evidence that incentive processes may play a role in alcohol consumption and in alcohol- related activities. The present plan of investigation has two objectives: (i) to investigate the control of alcohol-seeking activities by the animal's evaluation of the incentive properties of alcohol reward; and (ii) to investigate the effects of Pavlovian cues for ethanol on actions acquired for natural rewards and for ethanol. First, two pilot studies will be conducted in order to establish an effective, reliable method for the induction of alcohol consumption and for producing alcohol dependence in rats. To assess the role of the incentive value of ethanol in the control of instrumental actions, the effect of priming on ethanol-seeking behavior in both dependent and non- dependent rats will be investigated in a series of experiments. The next experimental series will employ Pavlovian-instrumental transfer designs in order to examine the impact of alcohol- associated Pavlovian cues on (i) actions reinforced with natural rewards, to assess the general motivating influence of these cues, and (ii) selective effects in choice tasks, to assess the alcohol-specific arousal associated with these cues. The findings of these studies are expected to elucidate the nature of bidirectional influences of primary motivational processes on alcohol-seeking behavior, and may provide a model for understanding relapse in alcohol abuse.

关于动机过程在药物滥用中的作用的研究尚未解决控制寻求饮酒行为的动机过程与控制追求自然奖励的动机过程之间的关系，例如食物或液体。尽管几乎没有直接的证据来得出结论，即控制工具奖励控制寻求酒精的行为的动机过程，但有证据表明，激励过程可能在酒精消费和与酒精相关的活动中发挥作用。 目前的调查计划有两个目标：（i）通过动物对酒精奖励的激励特性的评估来调查寻求酒精活动的控制； （ii）研究帕夫洛维亚线索对乙醇的影响对获得自然奖励和乙醇的作用。 首先，将进行两项试点研究，以建立一种有效，可靠的方法来诱导酒精消耗和产生大鼠的酒精依赖性。 为了评估乙醇在控制仪器作用中的激励价值的作用，将在一系列实验中研究启动对依赖和非依赖大鼠乙醇行为的影响。下一个实验系列将采用帕夫洛维亚 - 乐器转移设计，以检查酒精相关的巴夫洛维亚线索对（i）对自然奖励加强的行动的影响，以评估这些提示的一般动机影响，以及（ii）选择任务中的选择性效果，以评估与这些提示相关的酒精特异性唤起。 这些研究的发现有望阐明主要动机过程对寻求酒精行为的双向影响的性质，并可能为理解酒精滥用的复发提供了模型。