Cell Phone Technology Targeting ART and Naltrexone Adherence and Alcohol Use

针对 ART 和纳曲酮依从性以及饮酒的手机技术

基本信息

批准号：
8603566
负责人：
Suzette V Glasner-Edwards
金额：
$ 16.81万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8603566
关键词：
AIDS prevention Adherence Adult Affect Aftercare Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Anti-Retroviral Agents Behavior Therapy Behavioral Car Phone Cellular Phone Clinical Clinical Trials Cognitive Therapy Communities Complement Coping Skills Cost Savings Coupled Data Development Drug abuse Evaluation Evidence based treatment Feedback Frequencies HIV HIV Infections HIV risk Health Healthcare Individual Infection Intervention Interview Investigation Measures Medical Medication Management Naltrexone Outcome Participant Pharmaceutical Preparations Pharmacotherapy Phase Population Protocols documentation Public Health Randomized Clinical Trials Recruitment Activity Relapse Relative (related person)Reporting Research Research Design Research Personnel Risk Risk Behaviors Self Efficacy Social support Substance abuse problem Techniques Technology Telephone Testing Text Time Treatment Protocols Treatment outcome alcohol abuse therapy alcohol relapse alcohol use disorder base computerized data processing cost effective cost effectiveness craving disorder later incidence prevention experience follow-up health care service utilization improved innovation intervention effect medication compliance method development prevent primary outcome programs psychologic psychosocial public health relevance reduced alcohol use response skills social therapy development transmission process treatment adherence treatment strategy trend user-friendly

AIDS prevention Adherence Adult Affect Aftercare Alcohol abuse Alcohol consumption Alcohol dependence Alcohol or Other Drugs use Anti-Retroviral Agents Behavior Therapy Behavioral Car Phone Cellular Phone Clinical Clinical Trials Cognitive Therapy Communities Complement Coping Skills Cost Savings Coupled Data Development Drug abuse Evaluation Evidence based treatment Feedback Frequencies HIV HIV Infections HIV risk Health Healthcare Individual Infection Intervention Interview Investigation Measures Medical Medication Management Naltrexone Outcome Participant Pharmaceutical Preparations Pharmacotherapy Phase Population Protocols documentation Public Health Randomized Clinical Trials Recruitment Activity Relapse Relative (related person)Reporting Research Research Design Research Personnel Risk Risk Behaviors Self Efficacy Social support Substance abuse problem Techniques Technology Telephone Testing Text Time Treatment Protocols Treatment outcome alcohol abuse therapy alcohol relapse alcohol use disorder base computerized data processing cost effective cost effectiveness craving disorder later incidence prevention experience follow-up health care service utilization improved innovation intervention effect medication compliance method development prevent primary outcome programs psychologic psychosocial public health relevance reduced alcohol use response skills social therapy development transmission process treatment adherence treatment strategy trend user-friendly

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项目摘要

DESCRIPTION (provided by applicant): The objective of the current research is to improve treatment for alcohol dependent adults by augmenting naltrexone pharmacotherapy with an innovative text-messaging strategy to promote relapse prevention skills, reduce HIV-risk behaviors, and improve naltrexone and HIV treatment regimen adherence. This application is in response to PA-10-013, "Behavioral & Integrative Treatment Development Program," which encourages "Studies on evidence-based treatment interventions that utilize various technologies in order to increase efficacy and/or increase community-friendliness; Research on behavioral treatments that complement and/or potentiate the effects of medications; Research on treatment interventions for...medical conditions that are co- occurring with substance abuse; and research on the development of methods and technologies relevant to treatment, adherence, and HIV prevention within the context of drug abuse treatment." Consistent with these stated objectives of the PA, the specific aims of this research are 1) To develop and refine, with user feedback, a cognitive behavioral therapy-based text-messaging intervention (TXT-CBT) to augment pharmacotherapy for alcohol dependence in HIV-infected adults with alcohol use disorders; 2) To conduct a pilot randomized clinical trial to assess the feasibility of recruiting and retaining individuals for a large scale study and to determine the effect size of TXT-CBT over and above medication management with naltrexone (MM) on alcohol use, HIV medication adherence, naltrexone adherence, and healthcare outcomes. Both MM and MM+TXT-CBT participants will be assessed at baseline, treatment-end, and 12 weeks post-treatment; and 3) To examine potential mechanisms of action of TXT-CBT, including self-efficacy, coping skills, and social support. We hypothesize that TXT-CBT delivered in conjunction with MM will produce greater reductions in alcohol use and HIV-risk behaviors, and will improve naltrexone and HIV treatment regimen adherence, relative to MM alone. Further, we expect that MM+TXT-CBT will facilitate greater changes in, self-efficacy, coping skills, and social support, and these changes will be associated with substance use outcomes. Preliminary data concerning cost-effectiveness will be gathered to begin to evaluate the cost savings associated with this technology-based intervention. TXT-CBT incorporates specific substance- and adherence-focused cognitive therapy techniques with a concurrent emphasis on reducing HIV-risk behaviors. By providing support to maximize HIV treatment regimen adherence, coupled with coping skills to prevent alcohol relapse, TXT-CBT may provide a promising, cost-effective, and easily deployable augmenting strategy for the treatment of alcohol users who are HIV- infected.

描述（由申请人提供）：当前研究的目的是通过通过创新的文本编写策略来增强纳曲酮药物疗法来改善依赖酒精依赖的成年人的治疗，以促进预防复发技巧，减少艾滋病毒风险的行为，改善纳尔特雷酮和艾滋病毒治疗方案。该应用是对PA-10-013的“行为和综合治疗开发计划”的回应，该计划鼓励“基于证据的治疗干预措施进行研究，这些干预措施利用各种技术来提高疗效和/或增加社区友好性；对互补和/或增强治疗方法的治疗方法的行为治疗的研究；对治疗的影响；对治疗方法的侵害；对治疗方法的研究和疾病的疾病和造成的疾病和造成的疾病和疾病的疾病及其造成的疾病和现象的疾病;在药物滥用治疗的背景下，与治疗，依从性和HIV预防有关。”与PA的这些既定目标一致，这项研究的具体目的是1）开发和完善，用户反馈是一种基于认知行为疗法的文本介绍干预措施（TXT-CBT），以增强针对艾滋病毒感染的艾滋病毒感染的艾滋病毒疗法的药物依赖性药物患者的酒精疾病； 2）进行试验随机临床试验，以评估招募和保留个体进行大规模研究，并确定Naltrexone（MM）对药物管理（MM）对酒精使用，HIV药物依从性，Naltrexone依从性和医疗保健结果的影响。 MM和MM+TXT-CBT参与者将在基线，治疗末端和治疗后12周进行评估； 3）检查TXT-CBT行动的潜在机制，包括自我效能，应对技巧和社会支持。我们假设与MM结合使用的TXT-CBT将产生更大的饮酒和HIV风险行为，并且相对于单独的MM，将改善Naltrexone和HIV治疗方案的依从性。此外，我们预计MM+TXT-CBT将促进更大的变化，自我效能，应对技能和社会支持，这些变化将与药物使用结果相关。将收集有关成本效益的初步数据，以开始评估与此基于技术的干预相关的成本节省。 TXT-CBT结合了特定的物质和依从性认知疗法技术，并同时强调减少艾滋病毒风险行为。通过提供支持以最大化艾滋病毒治疗方案的依从性，再加上应对技巧以防止酒精复发，TXT-CBT可能会为患有艾滋病毒感染的酒精用户提供一种有希望，成本效率且易于部署的增强策略。