Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectiveness
诊断和预防美国青少年和年轻人的艾滋病毒感染:临床影响和成本效益
基本信息
- 批准号:10772663
- 负责人:
- 金额:$ 7.46万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-04-07 至 2024-03-31
- 项目状态:已结题
- 来源:
- 关键词:AIDS preventionAdherenceAdolescent and Young AdultAffectAgeAreaBehaviorCOVID-19 pandemicCaringClinicalClinical InvestigatorClinical ResearchClinical TrialsCollaborationsCommunicable DiseasesComputer SimulationCost Effectiveness AnalysisDerivation procedureDevelopmentDiagnosisEffectivenessEpidemicFoundationsFutureGeneral HospitalsGoalsHIVHIV InfectionsHIV diagnosisHIV-infected adolescentsHealth Care CostsHealth PolicyHealth behaviorInfectionK-Series Research Career ProgramsMassachusettsMentorsMethodologyMethodsModalityModelingNIH Office of AIDS ResearchNational Institute of Child Health and Human DevelopmentObservational StudyOutcomePathway interactionsPatterns of CarePerformancePharmaceutical PreparationsPhysiciansPoliciesPreventionResearchResearch PriorityRiskScientistServicesStructureTimeTrainingWorkYouthcare seekingcareercareer developmentcost effectivenessdisorder preventionhealth care deliveryimprovedmedication compliancemodel developmentmodels and simulationnovelnovel strategiespre-exposure prophylaxispreventprevention serviceresearch and developmentscreeningscreening servicestransmission processtreatment adherenceyoung men who have sex with men
项目摘要
Project Summary/Abstract
New HIV infections among youth ages 13-24 comprise 22% of all new HIV infections in the US. More than
60,000 adolescents and young adults (AYA) are already living with HIV in the US, and new infections
contribute substantially to HIV transmission. The HIV epidemic among US AYA demands new approaches to
HIV diagnosis and prevention, with consideration of the challenges of health care delivery and research among
AYA living with and at risk of acquiring HIV. Computer simulation health-policy models can add substantial
value to clinical trials and observational studies by projecting outcomes beyond the time horizon of clinical
studies. This is particularly important for AYA, in whom the effects of HIV infection and treatment may not
manifest for many years. This mentored clinical scientist research career development award will allow the
recipient, an infectious diseases physician at Massachusetts General Hospital, to develop a research career
using modeling methods and cost-effectiveness analysis to evaluate current critical questions in HIV
prevention and screening in US AYA. Reducing incident HIV infections, improving HIV screening, optimizing
HIV pre-exposure prophylaxis services, and assessing HIV pre-exposure prophylaxis effectiveness are high-
priority areas for the NIH Office of AIDS Research (2018 Goals) and NICHD (2017 New Research Priorities).
Collaborating with national studies of AYA affected by HIV, this project will develop a new, comprehensive
health policy model of HIV disease prevention, diagnosis and treatment in AYA. The model will reflect age- and
developmentally-specific AYA patterns of care-seeking behaviors, including engagment in care and adherence
to medications. The model will be used to evaluate the short- and long-term clinical outcomes and healthcare
costs associated with the screening and prevention of HIV in US AYA, focusing on a key sub-population,
young men who have sex with men.This work will build a foundation for future analyses of the delivery of HIV
pre-exposure prophylaxis and other emerging screening, treatment and prevention modalities. This mentored
research will be accompanied by relevant training in model development, derivation of trial-based model
inputs, and performance of policy-relevant analyses. This research and career development training provide
the recipient with a pathway to an independent career as a clinical investigator, focused on using modeling
methodology to optimize care for adolescents and young adults affected by HIV.
项目摘要/摘要
13-24岁青年中的新艾滋病毒感染占美国所有新艾滋病毒感染的22%。多于
60,000名青少年和年轻人(AYA)已经在美国患有艾滋病毒和新感染
对艾滋病毒的传播做出了基本贡献。我们中间的艾滋病毒流行我们需要新的方法
HIV诊断和预防,考虑到医疗保健提供和研究的挑战
Aya与获取艾滋病毒的风险同在。计算机模拟健康政策模型可以增加大量
通过预测超出临床时间范围的结果,对临床试验和观察性研究的价值
研究。这对于AYA尤其重要,其中HIV感染和治疗的影响可能不会
表现多年。这个受过指导的临床科学家研究职业发展奖将使
接受者是马萨诸塞州综合医院的传染病医师,以发展研究生涯
使用建模方法和成本效益分析来评估当前的艾滋病毒关键问题
预防和筛选美国。减少事件HIV感染,改善HIV筛查,优化
HIV暴露前的预防服务,评估HIV暴露前预防有效性是高的
NIH艾滋病研究办公室(2018年目标)和NICHD(2017年新研究优先事项)的优先领域。
该项目与受艾滋病毒影响的AYA的国家研究合作,将开发一个新的,全面的
AYA中的HIV疾病预防,诊断和治疗的卫生政策模型。该模型将反映年龄和
寻求护理行为的开发特定的AYA模式,包括订婚和遵守
进行药物。该模型将用于评估短期和长期临床结果和医疗保健
与美国AYA筛查和预防HIV相关的成本,重点是关键的子人群,
与男人发生性关系的年轻人。这项工作将为未来分析艾滋病毒的分析奠定基础
暴露前预防和其他新出现的筛查,治疗和预防方式。这是指导的
研究将伴随模型开发中的相关培训,基于试验模型的推导
输入和与政策相关的分析的绩效。这项研究和职业发展培训提供
具有临床研究者独立职业途径的接收者,专注于使用建模
优化对受艾滋病毒影响的青少年和年轻人的护理的方法。
项目成果
期刊论文数量(4)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Incidence, Predictors, and Outcomes of Implantable Cardioverter-Defibrillator Discharge Among People Living With HIV.
- DOI:10.1161/jaha.118.009857
- 发表时间:2018-09-18
- 期刊:
- 影响因子:5.4
- 作者:Alvi RM;Neilan AM;Tariq N;Awadalla M;Rokicki A;Hassan M;Afshar M;Mulligan CP;Triant VA;Zanni MV;Neilan TG
- 通讯作者:Neilan TG
Screening for HIV and linkage to care in adolescents: insights from a systematic review of recent interventions in high- versus low- and middle-income settings.
青少年艾滋病毒筛查及其与护理的联系:对高收入和低收入和中等收入环境中近期干预措施的系统回顾的见解。
- DOI:10.2147/ahmt.s153204
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Zanoni,BrianC;Elliott,RyanJ;Neilan,AnneM;Haberer,JessicaE
- 通讯作者:Haberer,JessicaE
The Cost-effectiveness of Transplanting Hearts From Hepatitis C-infected Donors Into Uninfected Recipients.
- DOI:10.1097/tp.0000000000004378
- 发表时间:2023-04-01
- 期刊:
- 影响因子:6.2
- 作者:
- 通讯作者:
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Anne Neilan其他文献
Anne Neilan的其他文献
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{{ truncateString('Anne Neilan', 18)}}的其他基金
Adolescent-tailored HIV treatment and prevention strategies in South Africa: projecting clinical benefits and value
南非针对青少年的艾滋病毒治疗和预防策略:预测临床效益和价值
- 批准号:
10619497 - 财政年份:2022
- 资助金额:
$ 7.46万 - 项目类别:
Adolescent-tailored HIV treatment and prevention strategies in South Africa: projecting clinical benefits and value
南非针对青少年的艾滋病毒治疗和预防策略:预测临床效益和价值
- 批准号:
10707187 - 财政年份:2022
- 资助金额:
$ 7.46万 - 项目类别:
Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectiveness
诊断和预防美国青少年和年轻人的艾滋病毒感染:临床影响和成本效益
- 批准号:
10450185 - 财政年份:2018
- 资助金额:
$ 7.46万 - 项目类别:
Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectiveness
诊断和预防美国青少年和年轻人的艾滋病毒感染:临床影响和成本效益
- 批准号:
9756435 - 财政年份:2018
- 资助金额:
$ 7.46万 - 项目类别:
Diagnosing and preventing HIV infection in adolescents and young adults in the US: clinical impact and cost-effectiveness
诊断和预防美国青少年和年轻人的艾滋病毒感染:临床影响和成本效益
- 批准号:
10223390 - 财政年份:2018
- 资助金额:
$ 7.46万 - 项目类别:
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