Achieving successful treatment outcomes among adolescents and pregnant/postpartum women living with HIV in Kenya

在肯尼亚感染艾滋病毒的青少年和孕妇/产后妇女中取得成功的治疗结果

基本信息

批准号：
10760594
负责人：
Lisa Lynn Abuogi
金额：
$ 19.16万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-09-14 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10760594
关键词：
AIDS prevention Address Adherence Adolescent Adolescent and Young Adult Adult Award Behavior Therapy Behavioral Sciences Caring Child Clinic Collaborations Colorado Counseling Dedications Disparity Electronics Enrollment Ensure Extramural Activities Failure Focus Groups Funding Goals HIV Health Impact evaluation Infrastructure Intervention Intervention Studies Interview Kenya Knowledge Mentors Mentorship Midcareer Investigator Award in Patient-Oriented Research Modeling NIH Office of AIDS Research Outcome Parents Participant Patients Pediatric Hospitals Pediatrics Perception Persons Physician Executives Physicians Population Postpartum Period Postpartum Women Pregnant Women Prevention program Productivity Provider Psychosocial Assessment and Care Qualifying Randomized Readiness Research Research Activity Research Personnel Research Priority Resource-limited setting Sampling Science Scientist Site Structure Time Training Treatment Failure Treatment outcome United States National Institutes of Health Universities Viral Visit Vulnerable Populations Woman Work Youth antenatal care antiretroviral therapy care outcomes career empowerment evidence base experience global health health disparity implementation science improved innovation mid-career faculty multidisciplinary next generation patient oriented research peer peer support pregnant prevent primary outcome recruit resilience skills standard of care success treatment risk uptake young adult young woman

项目摘要

Project Summary Overview: This K24 mid-career investigator award in patient-oriented research and mentorship proposes to expand the research and mentorship activities of a highly qualified candidate, Dr. Lisa Abuogi, focused on improving HIV and health outcomes for people living with HIV in high burden, low resource settings. Candidate: Dr. Abuogi is a physician-scientist trained in pediatrics, global health, and HIV and an Associate Professor at the University of Colorado Denver (UCD). She is also a Senior Investigator in the UCD Center for Global Health and Medical Director of the Children's Hospital HIV Prevention Program. Dr. Abuogi conducts patient-oriented research to address disparities in HIV health outcomes, including retention in care and viral suppression, among pregnant women, adolescents and children living with HIV. She has a sustained track record of extramural funding and demonstrated dedication to successful mentorship of new investigators. Mentoring Plan: Dr. Abuogi has a demonstrated commitment to highly successful mentorship of a diverse group of mentees. She has the ability to recruit multidisciplinary mentees from a wide range of research collaborations and networks, a structured approach to ensure high quality mentorship, and a commitment to build the next generation of investigators committed to research aimed addressing knowledge gaps and at improving HIV outcomes. Research Plan: Dr. Abuogi's proposed research activities address NIH's Office of AIDS Research Priority Research agenda in Cross Cutting research that includes implementation and behavioral sciences, health disparities, and training and capacity building. Leveraging her ongoing NIH-funded research evaluating behavioral interventions to improve HIV care outcomes for both pregnant/postpartum and on 1, viral women and adolescents young adults living with HIV (AYA), Dr. Abuogi proposes innovative new patient-oriented research focused the sustainable impact f interventions aimed a improving engagement in care and viral suppression. In Aim Dr. Abuogi will examine the effect of short-term peer navigation on long-term sustained re-engagement and suppression in AYA on antiretroviral treatment after navigation is discontinued. In Aim 2, o t determine the impact of behavioral interventions on care transitions in these populations. Finally, in Aim 3, she will explore the perceptions of patients and LHW on how the interventions support treatment success as well as unintended consequences of peer-led interventions to inform iterative adaptations of these interventions. proposed evidence-based provide The newly research described in this application will expand our understanding of the sustainable impact of interventions aimed at improving treatment outcomes for vulnerable populations with HIV and research opportunities for new mentees.

项目摘要概述：这项K24职业中期研究者授予以患者为导向的研究和指导奖提议扩大高素质候选人Lisa Abuogi博士的研究和指导活动，专注于改善艾滋病毒患者处于高负担，低资源环境中的艾滋病毒和健康成果。候选人：Abuogi博士是一名医生科学家，接受了儿科，全球健康和艾滋病毒的培训，也是同事科罗拉多大学丹佛大学（UCD）教授。她还是UCD中心的高级调查员儿童医院艾滋病毒预防计划的全球卫生和医疗总监。 Abuogi博士指挥面向患者的研究以解决HIV健康结果的差异，包括保留在护理和病毒方面在孕妇，青少年和艾滋病毒的儿童中，抑制。她有持续的记录校外资金，并表现出致力于成功的新研究人员的奉献精神。指导计划：Abuogi博士表现出对多元化群体的高度成功指导的承诺受训者。她有能力从广泛的研究合作中招募多学科的受训者和网络，一种结构化方法，以确保高质量的指导以及建立下一个的承诺致力于解决知识差距并改善艾滋病毒的研究人员的生成结果。研究计划：Abuogi博士提议的研究活动涉及NIH的艾滋病研究优先事项跨切割研究的研究议程，包括实施和行为科学，健康差异，培训和能力建设。利用她正在进行的NIH资助的研究评估行为干预措施以改善怀孕/产后的HIV护理结果和在 1，病毒性的妇女和青少年 Abuogi博士居住在艾滋病毒（AYA）的年轻人（aya），提议创新的面向患者的研究重点可持续的影响F干预措施旨在改善护理和病毒抑制的参与。目标 Abuogi博士将研究短期同伴导航对长期持续重新参与的影响导航后抗逆转录病毒治疗的AYA抑制。在AIM 2中， o t 确定行为干预对这些人群中护理转变的影响。最后，在AIM 3中，她将探索对患者和LHW的看法对干预措施如何支持治疗成功以及意外同伴主导的干预措施的后果，以告知这些干预措施的迭代改编。建议的循证提供新的本应用程序中描述的研究将扩大我们对旨在改善艾滋病毒和艾滋病毒脆弱人群的治疗结果的干预措施新受训者的研究机会。