Sex differences in the neural mechanisms of brief interventions for binge drinking

酗酒短暂干预神经机制的性别差异

基本信息

批准号：
9765029
负责人：
Jillian Elizabeth Hardee
金额：
$ 16.61万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2021-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9765029
关键词：
Address Age Alcohol abuse Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Aptitude Area Arousal Award Behavior Behavior Control Behavioral Behavioral Mechanisms Biomedical Engineering Brain Brief Alcohol Screening and Intervention for College Students Cessation of life Clinical Comorbidity Control Groups Cues Data Development Education Emotional Emotions Environment Faculty Female Foundations Functional Magnetic Resonance Imaging Funding Funding Agency Future Goals Impulse Control Disorders Impulsivity Individual Individual Differences Injury Interdisciplinary Study Intervention Knowledge Laboratories Lead Link Longitudinal Studies MRI Scans Measurement Measures Memory impairment Mentors Mentorship Methodology Michigan Motivation Names National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neural Pathways Neurobiology Neurosciences Outcome Overdose Pathway interactions Pattern Play Prevention program Prevention strategy Preventive Intervention Process Psychiatry Psychology Psychopathology Radiology Specialty Reading Research Research Personnel Research Project Grants Research Scientist Award Research Training Risk Risk Factors Role Scanning Schedule Scientist Sex Differences Substance abuse problem Techniques Time Training Translational Research Treatment outcome Universities University Health Services Unsafe Sex Work addiction aged alcohol cue alcohol related consequences alcohol related problem alcohol risk alcohol use disorder arm base binge drinker binge drinking brief alcohol intervention brief intervention career college college drinking cue reactivity disorder risk drinking experience fighting follow-up group intervention high risk drinking improved outcome intervention effect intervention program male mid-career faculty motivational enhancement therapy negative affect neural correlate neuroimaging neuromechanism physical assault problem drinker professor programs public health relevance recruit relating to nervous system remediation sex sexual assault stem success treatment strategy undergraduate student university student vandalism young adult

项目摘要

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Award will support me in establishing an independent research career using neuroimaging to investigate the role of individual differences in alcohol use disorder risk and treatment outcomes. The training component of this application builds on my neuroscience and neuroimaging background, which demonstrates a strong technical aptitude and provides a robust basic scientific foundation from which to study the psychopathology of substance risk. To achieve full research independence, I have identified four key training objectives: 1) obtain experience in a clinical setting in order to understand all aspects of alcohol use disorders and their treatment; 2 gain expertise in the area of sex differences and addiction; 3) acquire advanced training in statistical methodologies; and 4) increase knowledge about brief interventions and motivational interviewing techniques. I will be mentored through this process by Dr. Maureen Walton, Associate Professor, Department of Psychiatry at the University of Michigan, and Dr. Mary Heitzeg, Assistant Professor, Department of Psychiatry, University of Michigan. A team of carefully selected consultants will provide additional guidance and training. The proposed K01 project will take place within the University of Michigan Addiction Research Center (UMARC), Department of Psychiatry, a multidisciplinary research center that has been funded by NIAAA, NIDA, NIMH, and a number of other external funding sources to address addiction problems, their causes, and their remediation. Eighty other substance abuse research projects are active on the University of Michigan campus, and UMARC faculty interact and collaborate with these other scientists. The University's Functional MRI Laboratory is also a collaborative, interdisciplinary facility used by a number of researchers across many departments, including Psychiatry, Psychology, Biomedical Engineering, and Radiology, just to name a few. The University of Michigan's vigorous research environment nurtures an expanding group of neuroimaging researchers, including Dr. Heitzeg, who has been the lead of the neuroimaging arm of the Michigan Longitudinal Study for 8 years and was the recipient of a NIDA Early Career Investigator Award for her work in developmental neuroimaging and addiction. The research component focuses on identifying whether there are differences between male and female collegiate binge drinkers in neural regions associated with risk for alcohol use disorders--impulse control, emotion processing, and alcohol cue reactivity--and how these regions change after a brief intervention. There is substantial behavioral evidence for disparities in risk trajectories such that females tend to score higher of measures of negative affect and males tend to score higher on measures of impulsivity. This can extend into young adulthood when binge drinking and negative consequences stemming from this type of behavior becomes problematic. Additionally, brief interventions have been shown to be effective for collegiate binge drinkers, with some mixed outcomes regarding male and female success rates. How sex differences moderate the neurobiology of addiction is understudied; a more careful examination of these differences would be beneficial for the development of targeted prevention and intervention programs. Here, functional magnetic resonance imaging (fMRI) will be conducted in two groups of binge drinking college students between the ages of 18-20yrs, with equal numbers of males and females in each group (n=100 total). One group (BI group) will be recruited from the University of Michigan University Health Services BASICS program (a brief alcohol intervention program for college students), and will partake in a baseline fMRI scan prior to beginning the program, and a follow-up scan immediately after the program finishes. The other group (Control group) will be recruited from campus and will only receive educational information about alcohol use. They will partake in a baseline and follow-up fMRI scan on the same time schedule as the BI group. Measures of emotional functioning, drinking motives, alcohol consumption, and alcohol-related problems will be measured at each scan, as well as 3 and 6 months post-scan. The research specific aims are: 1) examine sex differences in binge drinking risk factors, motivations, and underlying neural correlates at baseline in collegiate bing drinkers; 2) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking; and 3) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking. I will accomplish these research and training goals through close mentorship from a team with expertise in these content areas, didactic coursework, and directed readings.

描述（由申请人提供）：该 K01 指导研究科学家奖将支持我建立一个独立的研究生涯，利用神经影像学来研究个体差异在酒精使用障碍风险和治疗结果中的作用。该申请的培训部分建立在我的神经科学的基础上。和神经影像学背景，这表现出强大的物质技术能力，并为研究风险精神病理学提供了坚实的基础科学基础。为了实现完全的研究独立性，我确定了四个关键培训目标：1）获得经验。在临床环境中，了解酒精使用障碍及其治疗的各个方面；2 获得性别差异和成瘾领域的专业知识；3）获得统计方法方面的高级培训；4）增加有关简短干预和治疗的知识；在这个过程中，我将得到密歇根大学精神病学系副教授 Maureen Walton 博士和密歇根大学精神病学系助理教授 Mary Heitzeg 博士的精心指导。已选择拟议的 K01 项目将在密歇根大学精神病学系的成瘾研究中心 (UMARC) 内进行，该中心是一个由 NIAAA、NIDA、NIMH 和许多机构资助的多学科研究中心。密歇根大学校园内正在开展其他 80 个药物滥用研究项目，以解决成瘾问题、其原因及其补救措施，并且 UMARC 教职人员与该大学的其他科学家进行互动和合作。 MRI 实验室也是一个协作的跨学科设施，由多个部门的许多研究人员使用，其中包括精神病学、心理学、生物医学工程和放射学等。密歇根大学充满活力的研究环境培养了越来越多的神经影像研究人员。包括 Heitzeg 博士，她担任密歇根纵向研究神经影像部门的负责人长达 8 年，并因其在发育神经影像和成瘾方面的工作而获得 NIDA 早期职业研究者奖。该研究的重点是确定男性和女性大学酗酒者在与酒精使用障碍风险相关的神经区域（冲动控制、情绪处理和酒精暗示反应）是否存在差异，以及这些区域在短暂干预后如何变化有大量的行为证据表明风险轨迹存在差异，例如女性在负面情绪方面得分较高，而男性在冲动方面得分较高，这种情况可能会延续到成年早期，当酗酒和由此产生的负面后果时。研究表明，简短的干预措施对于大学酗酒者是有效的，但对于性别差异如何调节成瘾的神经生物学尚未得到充分研究。有利于制定有针对性的预防和干预计划。在这里，功能磁共振成像（fMRI）将在两组年龄在18-20岁之间的酗酒大学生中进行，每组中男女人数相等。（总共 100 人）。一组（BI 组）将从密歇根大学健康服务基础计划（针对大学生的简短酒精干预计划）中招募，并将在开始该计划之前参加基线功能磁共振成像扫描。，并在计划结束后立即进行后续扫描，另一组（对照组）将从校园招募，并且仅接收有关饮酒的教育信息，他们将在同一组中参加基线和后续功能磁共振成像扫描。 BI 小组的时间表。每次扫描以及扫描后 3 个月和 6 个月都会测量情绪功能、饮酒动机、饮酒和酒精相关问题的情况。该研究的具体目标是：1）检查酗酒风险因素的性别差异。大学酗酒者的动机和基线的潜在神经相关性；2）表征短暂干预酗酒的神经变化机制的性别差异；3）表征短暂干预酗酒的神经变化机制的性别差异。我会完成这些研究和培训目标是通过在这些内容领域、教学课程和定向阅读方面具有专业知识的团队的密切指导实现的。