Sex differences in the neural mechanisms of brief interventions for binge drinking

酗酒短暂干预神经机制的性别差异

基本信息

批准号：
10001409
负责人：
Jillian Elizabeth Hardee
金额：
$ 16.61万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-01 至 2022-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10001409
关键词：
Address Age Alcohol abuse Alcohol consumption Alcohol dependence Alcoholic beverage heavy drinker Alcohols Aptitude Area Arousal Award Behavior Behavior Control Behavioral Behavioral Mechanisms Biomedical Engineering Brain Brief Alcohol Screening and Intervention for College Students Cessation of life Clinical Control Groups Cues Data Development Education Emotional Emotions Environment Faculty Female Foundations Functional Magnetic Resonance Imaging Funding Funding Agency Future Goals Impulse Control Disorders Impulsivity Individual Individual Differences Injury Interdisciplinary Study Intervention Knowledge Laboratories Lead Link Longitudinal Studies Measurement Measures Memory impairment Mentors Mentorship Methodology Michigan Motivation Names National Institute of Drug Abuse National Institute of Mental Health National Institute on Alcohol Abuse and Alcoholism Neural Pathways Neurobiology Neurosciences Outcome Overdose Pathway interactions Pattern Play Prevention program Prevention strategy Preventive Intervention Process Psychiatry Psychology Psychopathology Radiology Specialty Reading Research Research Personnel Research Project Grants Research Scientist Award Research Training Risk Risk Factors Role Scanning Schedule Scientist Sex Differences Substance abuse problem Techniques Time Training Translational Research Treatment outcome Universities University Health Services Unsafe Sex Work addiction aged alcohol cue alcohol related consequences alcohol related problem alcohol risk alcohol use disorder arm base binge drinker binge drinking brief alcohol intervention brief intervention career college college drinking comorbidity cue reactivity disorder risk drinking emotional functioning experience fighting follow-up functional MRI scan group intervention high risk drinking improved outcome intervention effect intervention program male mid-career faculty motivational enhancement therapy negative affect neural correlate neuroimaging neuromechanism physical assault problem drinker professor programs public health relevance recruit relating to nervous system remediation sex sexual assault stem success treatment strategy undergraduate student university student vandalism young adult

项目摘要

DESCRIPTION (provided by applicant): This K01 Mentored Research Scientist Award will support me in establishing an independent research career using neuroimaging to investigate the role of individual differences in alcohol use disorder risk and treatment outcomes. The training component of this application builds on my neuroscience and neuroimaging background, which demonstrates a strong technical aptitude and provides a robust basic scientific foundation from which to study the psychopathology of substance risk. To achieve full research independence, I have identified four key training objectives: 1) obtain experience in a clinical setting in order to understand all aspects of alcohol use disorders and their treatment; 2 gain expertise in the area of sex differences and addiction; 3) acquire advanced training in statistical methodologies; and 4) increase knowledge about brief interventions and motivational interviewing techniques. I will be mentored through this process by Dr. Maureen Walton, Associate Professor, Department of Psychiatry at the University of Michigan, and Dr. Mary Heitzeg, Assistant Professor, Department of Psychiatry, University of Michigan. A team of carefully selected consultants will provide additional guidance and training. The proposed K01 project will take place within the University of Michigan Addiction Research Center (UMARC), Department of Psychiatry, a multidisciplinary research center that has been funded by NIAAA, NIDA, NIMH, and a number of other external funding sources to address addiction problems, their causes, and their remediation. Eighty other substance abuse research projects are active on the University of Michigan campus, and UMARC faculty interact and collaborate with these other scientists. The University's Functional MRI Laboratory is also a collaborative, interdisciplinary facility used by a number of researchers across many departments, including Psychiatry, Psychology, Biomedical Engineering, and Radiology, just to name a few. The University of Michigan's vigorous research environment nurtures an expanding group of neuroimaging researchers, including Dr. Heitzeg, who has been the lead of the neuroimaging arm of the Michigan Longitudinal Study for 8 years and was the recipient of a NIDA Early Career Investigator Award for her work in developmental neuroimaging and addiction. The research component focuses on identifying whether there are differences between male and female collegiate binge drinkers in neural regions associated with risk for alcohol use disorders--impulse control, emotion processing, and alcohol cue reactivity--and how these regions change after a brief intervention. There is substantial behavioral evidence for disparities in risk trajectories such that females tend to score higher of measures of negative affect and males tend to score higher on measures of impulsivity. This can extend into young adulthood when binge drinking and negative consequences stemming from this type of behavior becomes problematic. Additionally, brief interventions have been shown to be effective for collegiate binge drinkers, with some mixed outcomes regarding male and female success rates. How sex differences moderate the neurobiology of addiction is understudied; a more careful examination of these differences would be beneficial for the development of targeted prevention and intervention programs. Here, functional magnetic resonance imaging (fMRI) will be conducted in two groups of binge drinking college students between the ages of 18-20yrs, with equal numbers of males and females in each group (n=100 total). One group (BI group) will be recruited from the University of Michigan University Health Services BASICS program (a brief alcohol intervention program for college students), and will partake in a baseline fMRI scan prior to beginning the program, and a follow-up scan immediately after the program finishes. The other group (Control group) will be recruited from campus and will only receive educational information about alcohol use. They will partake in a baseline and follow-up fMRI scan on the same time schedule as the BI group. Measures of emotional functioning, drinking motives, alcohol consumption, and alcohol-related problems will be measured at each scan, as well as 3 and 6 months post-scan. The research specific aims are: 1) examine sex differences in binge drinking risk factors, motivations, and underlying neural correlates at baseline in collegiate bing drinkers; 2) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking; and 3) characterize sex differences in neural mechanisms of change underlying a brief intervention for binge drinking. I will accomplish these research and training goals through close mentorship from a team with expertise in these content areas, didactic coursework, and directed readings.

描述（由应用程序提供）：这项K01指导的研究科学家奖将支持我建立独立的研究职业，利用神经影像来调查个体差异在酒精使用障碍风险和治疗结果中的作用。该应用程序的培训组成部分是基于我的神经科学和神经影像学背景，该背景证明了强大的技术才能，并提供了强大的基本科学基础，可以从中研究物质风险的心理病理学。为了实现全面的研究独立性，我确定了四个关键的培训目标：1）在临床环境中获得经验，以了解酒精使用障碍的各个方面及其治疗； 2在性别差异和成瘾领域获得专业知识； 3）获得统计方法的高级培训； 4）增加有关简短干预措施和动机访谈技术的知识。密歇根大学精神病学系副教授Maureen Walton博士和密歇根大学精神病学系助理教授Mary Heitzeg博士将通过此过程进行指导。精心挑选的顾问团队将提供其他指导和培训。拟议的K01项目将在密歇根大学成瘾研究中心（UMARC）内，精神病学系（UMARC），该部门是由NIAAA，NIDA，NIMH和许多其他外部资金来解决的多学科研究中心，以及解决成瘾问题，原因，其原因及其补习。密歇根大学校园还活跃于其他八十种药物滥用研究项目，UMARC教师与其他科学家进行了互动并合作。该大学的功能性MRI实验室也是许多研究人员在许多部门中使用的合作，跨学科的设施，包括精神病学，心理学，生物医学工程和放射学，仅举几例。密歇根大学有力的研究环境护士护士不断扩大神经影像学研究人员，其中包括Heitzeg博士，他一直是密歇根州纵向研究的神经影像学部门已有8年了，并获得了NIDA早期职业研究员的发展神经化和成瘾的工作。该研究组成部分着重于确定男性和女性大学饮酒者在与酒精使用障碍风险相关的神经科中是否存在差异 - 冲突控制，情绪加工和酒精提示反应性以及在短暂干预后这些地区如何变化。在风险轨迹中分布有大量的行为证据，使女性倾向于在负面影响的测量中得分更高，而男性在冲动性的测量中往往得分更高。当Benge饮酒和这种行为带来的负面后果变得有问题时，这可以扩展到年轻的成年。此外，已经证明简短的干预措施对大学饮酒者有效，关于男性和女性的成功率有些不同。性别差异如何适应成瘾的神经生物学被研究；对这些差异进行更仔细的检查将有助于制定有针对性的预防和干预计划。在这里，功能性磁共振成像（fMRI）将在两组18至20岁之间的两组暴饮暴食的大学生中进行，每组中的男性和女性数量相等（n = 100个）。将从密歇根大学卫生服务基础计划（针对大学生的简短酒精干预计划）招募一个小组（BI小组），并将在开始该计划之前进行基线fMRI扫描，并在计划完成后立即进行后续扫描。另一组（对照组）将从校园招募，并且只会获得有关酒精使用的教育信息。他们将在与BI组的同一时间表下进行基线和随访fMRI扫描。每次扫描以及扫描后的3个月和6个月，将测量情绪功能，饮酒动机，饮酒和与酒精有关的问题的衡量标准。该研究的具体目的是：1）研究饮酒者基线时的暴饮暴食危险因素，动机和潜在的神经相关性的性别差异； 2）在短暂干预暴饮暴食的基础上的神经机制中表征性别差异； 3）表征性别差异在变化的神经机制中，简短干预暴饮暴食。我将通过在这些内容领域，教学课程和定向阅读的团队的紧密心态来完成这些研究和培训目标。