LONG TERM EFFECTS OF TEMPORAL LOBE EPILEPSY

颞叶癫痫的长期影响

• 批准号: 6187986
• 负责人: H REBECCA RAUSCH
• 金额: $ 20.19万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-02 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6187986
• 关键词: aging; behavior; behavioral /social science research tag; clinical research; cognition; emotions; functional ability; human subject; human therapy evaluation; longitudinal human study; neuropsychological tests; neurosurgery; partial seizure; postoperative complications; postoperative state; social adjustment

DESCRIPTION: The major goal of the proposed research is to provide much needed information as to the long-term behavior effects of temporal-lobe surgery. Temporal lobe surgery is the most frequently performed epilepsy surgery procedure. The clinical results of such surgery have been impressive. However, reports of the behavioral sequelae of surgery are limited, with most studies performed within the first year after surgery. While improvement in emotional and social domains have been reported in the short-term follow-up in the successfully-treated patients, the behavioral sequelae is not always positive. No long-term longitudinal studies of the behavioral effects of temporal lobe surgery are available. The proposed research meets the need for a systematic investigation of the long-term impact of temporal lobe surgery on medical, social and emotional functioning. Studies are based on the longitudinal follow-up of persons who had intractable epilepsy and who underwent a standardized clinical and psychological evaluation in a large university surgical diagnostic center. Three groups of patients are followed: Patients who underwent a standardized temporal lobe resection, patients who underwent an extra- temporal lobe resection and a comparison group of patients who underwent the same pre-surgical evaluation but did not qualify for/or refused surgery. The proposed studies will determine the extent to which the changes seen one year and 5 years after temporal lobe surgery are similar to those seen greater than 9 years post surgery. The interrelationship of emotional, cognitive, and social changes and selected clinical measures will be determined. Finally, as these patients approach ages when normal aging process begin, potential late changes in behavior will be identified. These changes will be related to the impact of seizures and other related treatment effects. These findings will be invaluable to clinicians and general health-care providers involved in clinical decisions on the surgical treatment of epilepsy. Such information will also be important for neurobehavioral scientists interested in following the temporal sequelae of brain lesions with respect to increasing deficits and tot potential recovery mechanisms and neuronal plasticity. Finally, the proposed work will provide prognostic indices for those involved in providing patient rehabilitation services.

描述：拟议研究的主要目标是提供很多 有关颞叶的长期行为影响的所需信息 外科手术。颞叶手术是最常执行的癫痫 手术程序。这种手术的临床结果已经 感人的。但是，手术后遗症的报告是 有限，大多数研究在手术后的第一年内进行。 尽管已经报道了情感和社会领域的改善 成功治疗的患者的短期随访， 行为后遗症并不总是积极的。没有长期纵向 有关颞叶手术的行为影响的研究。 拟议的研究满足了对 颞叶手术对医疗，社会和情感的长期影响 功能。研究基于人的纵向随访 患有顽固性癫痫的人，谁接受了标准化的临床和 大型大学外科诊断中心的心理评估。 遵循三组患者：接受A的患者 标准化的颞叶切除术，接受过特级的患者 颞叶切除和接受的患者比较组 相同的外科术前评估，但没有资格/或拒绝 外科手术。拟议的研究将确定 颞叶手术后一年零5年看到的变化相似 对于手术后9年以上的人来说。相互关系 情感，认知和社会变化以及选定的临床措施 将确定。最后，随着这些患者正常时的年龄 开始衰老的过程开始，行为的潜在后期变化将是 确定。这些变化将与癫痫发作的影响有关 其他相关治疗效果。这些发现对 参与临床的临床医生和一般医疗保健提供者 关于癫痫手术治疗的决定。这样的信息将 对于有兴趣遵循的神经行为科学家也很重要 脑病变的颞后遗症相对于增加缺陷 以及潜在的恢复机制和神经元可塑性。最后， 拟议的工作将为参与的人提供预后指数 提供患者康复服务。