LONG-TERM EFFECTS OF TEMPORAL LOBE SURGERY

颞叶手术的长期影响

• 批准号: 2269223
• 负责人: H REBECCA RAUSCH
• 金额: $ 20.74万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-09-02 至 1997-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2269223
• 关键词: behavior test; cognition disorders; electroencephalography; functional ability; human subject; human therapy evaluation; longitudinal human study; mental disorder diagnosis; neurosurgery; partial seizure; postoperative complications; postoperative state; preoperative state; prognosis; temporal lobe /cortex disorder

The proposed research is designed to provide an understanding of long- term behavioral effects of temporal lobectomy surgery for intractable- epilepsy. the occurrence of intractable-seizures is well-known to impact negatively upon several quality of life domains, including cognition, emotion and social function. Surgical intervention is now an accepted treatment for epilepsy which is refractory to pharmacologic therapy, and temporal lobectomy is the most frequently performed epilepsy surgery. The clinical results of such surgery on seizure control have been impressive. However, reports on the behavioral sequelae of surgery for epilepsy have been limited, with most studies aimed at only the first year after surgery. No comprehensive, long-term follow-up of the behavioral effects of temporal lobe surgery are available. Hence, we plan to undertake a systematic re-assessment of patients who had undergone temporal lobe surgery for intractable-epilepsy at one-, five-, ten-, and fifteen-years ago. These patients had all participated in a standardized clinical and psychological research protocol at our institution and have available the results of routine diagnostic evaluations done prior to surgery. Additional groups of epilepsy patients who (a) participated in pre-surgical evaluations but did not quality for/or refused surgery or (b) had extra-temporal lobe resections will also be followed for comparison. The proposed work will provide information regarding the long-term cognitive, emotional, and social effects of temporal lobectomy surgery as well as aiding in identification of those critical factors affecting clinical outcome. Such results will be invaluable to clinicians, neurobehaviorists, and general healthcare- providers involved in patient management decisions regarding surgical treatment for epilepsy. Moreover, the proposed data bank will provide new direction in developing more effective patient-rehabilitation services after surgery and may contribute to our further understanding of the sequelae and plasticity of human behaviors associated with specific brain lesions.

拟议的研究旨在提供对长期的理解 颞叶切除手术对顽固性的术语行为影响 癫痫。 顽固性的发生是众所周知的 对包括认知在内的几个生活质量领域的负面负面 情绪和社会功能。 手术干预现在已被公认 癫痫的治疗，对药理治疗难治性， 颞叶切除术是最常见的癫痫手术。 这种对癫痫控制的手术的临床结果是 感人的。 但是，有关手术行为后遗症的报告 癫痫受到限制，大多数研究仅针对第一个 手术后一年。 没有全面的长期随访 可以使用颞叶手术的行为影响。 因此，我们 计划对患者进行系统的重新评估 经过了颞叶手术，以进行一，五个，五个，五个， 十五年前。 这些患者都参加了 我们的标准化临床和心理研究方案 机构，并获得了常规诊断的结果 在手术前进行的评估。 其他组癫痫 （a）参加手术前评估但未 /或拒绝手术的质量或（b）具有较高的叶切除术 还将遵循比较。 拟议的工作将提供 有关长期认知，情感和社会的信息 颞叶切除手术的影响以及帮助识别 在影响临床结果的关键因素中。 这样的结果将会 对于临床医生，神经行为者和一般医疗保健 - 参与患者管理的提供者有关手术的决定 治疗癫痫。 此外，拟议的数据库将提供 开发更有效的患者漏洞的新方向 手术后的服务，可能有助于我们进一步理解 与人类行为的后遗症和可塑性 特定的大脑病变。