SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

选定化学致癌物的合成

基本信息

批准号：
6286378
负责人：
SHANTU G AMIN
金额：
$ 23.67万
依托单位：
INSTITUTE FOR CANCER PREVENTION
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-05-16 至 2002-03-15
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6286378
关键词：
carbopolycyclic compound chemical carcinogen chemical synthesis chemoprevention epoxides high performance liquid chromatography mass spectrometry nuclear magnetic resonance spectroscopy optical rotation phenols quinones thin layer chromatography

项目摘要

The goal of this project is the synthesis, isolation, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. Some of these chemical standards will be new to the program and others will be synthesized to replace depleted chemical stocks. The contractors selected from this recompetition will have two major responsibilities. First, they will be responsible for the resynthesis of polycyclic aromatic hydrocarbons (PAH)-derivatives (primarily by established procedures) for the restocking of the NCI's Chemical Carcinogen Reference Standards Repository as necessary, and they will develop synthesis or purification procedures for the preparation of a wide spectrum of other selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives. The types of compounds, referred to as PAH metabolites, include dihydrodiols, phenols, quinones, enantiomeric diolepoxides, epoxides, dialdehydes resulting from the cleavage of vicinally-disubstituted oxygenated derivatives, alkyl- and hydroxyalkyl-substituted parent hydrocarbons, conjugated derivatives (chemical or biosynthetic such as glutathiones, glucuronides, and sulfates), and labeled (3H, 13C, 4C) analogs. The other focus of the workscope will include the synthesis of chemicals from selected carcinogen and chemopreventive classes.

该项目的目标是合成、分离、纯化和多种不同研究化合物的表征致癌研究界。其中一些化学标准将是该程序的新内容，其他内容将被合成以替换化学品库存耗尽。本次复赛入选的承包商将承担两项主要职责。首先，他们将负责多环芳烃（PAH）衍生物的再合成（主要按照既定程序）为 NCI 重新进货必要时建立化学致癌物参考标准库，并且它们将开发合成或纯化程序来制备广泛的其他选定的化学致癌物、化学预防制剂及其某些代谢物或衍生物。的类型化合物，称为 PAH 代谢物，包括二氢二醇、酚类、醌类、对映体二醇环氧化物、环氧化物、二醛邻位二取代的含氧衍生物、烷基和羟烷基取代的母体烃、共轭衍生物（化学或生物合成，如谷胱甘肽、葡萄糖醛酸和硫酸盐）和标记的（3H、13C、4C）类似物。另一个重点是工作范围将包括从选定的致癌物中合成化学品和化学预防课程。