SYNTHESIS OF SELECTED CHEMICAL CARCINOGENS

选定化学致癌物的合成

• 批准号: 2556677
• 负责人: SHANTU G AMIN
• 金额: $ 27.76万
• 依托单位: INSTITUTE FOR CANCER PREVENTION
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-05-16 至 2002-03-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2556677
• 关键词: carbopolycyclic compound; chemical carcinogen; chemical synthesis; chemoprevention; epoxides; high performance liquid chromatography; mass spectrometry; nuclear magnetic resonance spectroscopy; optical rotation; phenols; quinones; thin layer chromatography

The goal of this project is the synthesis, isolation, purification, and characterization of a number of different research compounds of interest to the carcinogenesis research community. Some of these chemical standards will be new to the program and others will be synthesized to replace depleted chemical stocks. The contractors selected from this recompetition will have two major responsibilities. First, they will be responsible for the resynthesis of polycyclic aromatic hydrocarbons (PAH)-derivatives (primarily by established procedures) for the restocking of the NCI's Chemical Carcinogen Reference Standards Repository as necessary, and they will develop synthesis or purification procedures for the preparation of a wide spectrum of other selected chemical carcinogens, chemopreventive agents and certain of their metabolites or derivatives. The types of compounds, referred to as PAH metabolites, include dihydrodiols, phenols, quinones, enantiomeric diolepoxides, epoxides, dialdehydes resulting from the cleavage of vicinally-disubstituted oxygenated derivatives, alkyl- and hydroxyalkyl-substituted parent hydrocarbons, conjugated derivatives (chemical or biosynthetic such as glutathiones, glucuronides, and sulfates), and labeled (3H, 13C, 4C) analogs. The other focus of the workscope will include the synthesis of chemicals from selected carcinogen and chemopreventive classes.

该项目的目的是综合，隔离，纯化和 表征许多感兴趣的不同研究化合物 致癌研究界。其中一些化学标准 将是该程序的新手，其他将合成以替换 耗尽的化学库存。从此重新挑选的承包商 将承担两个主要职责。 首先，他们将负责 多环子芳族烃（PAH）衍生物的重新合成 （主要通过既定程序）用于补货NCI 必要的化学致癌参考标准存储库，它们 将制定综合或纯化程序来制备 广泛的其他选定的化学致癌物，化学预防 代理商及其代谢物或衍生物。类型 化合物，称为PAH代谢产物，包括二氢二醇，苯酚， 奎因酮，对映体二醇氧化物，环氧化物，二醛由 替代分离的氧化衍生物，烷基和 羟基烷基取代的父烃，共轭衍生物 （化学或生物合成，例如谷胱甘肽，葡萄糖醛酸苷和 硫酸盐），并标记为（3H，13C，4C）类似物。另一个重点 Workscope将包括从选定的致癌物中合成化学物质 和化学预防类别。