CYSTEINE & GLUTATHIONE METABOLISM IN HEALTHY SUBJECTS

半胱氨酸

• 批准号: 6305675
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305675
• 关键词: aminoacid biosynthesis; aminoacid metabolism; clinical research; cysteine; dietary restriction; glutathione; human subject; nutrient bioavailability; nutrition related tag; protein metabolism

A pilot study aimed to determine basic aspects of cysteine and glutathione metabolism under conditions of a sulfur free amino acid diet. Cysteine availability is the rate limiting step in glutathione synthesis. We hypothesized that during a short term sulfur-free amino acid diet the rates of Glutathione synthesis are maintained at the expense of increased protein turnover.

一项试点研究旨在确定在硫氨基酸饮食条件下的半胱氨酸和谷胱甘肽代谢的基本方面。 半胱氨酸的可用性是谷胱甘肽合成的速率限制步骤。 我们假设在短期无硫氨基酸饮食中，谷胱甘肽合成的速率以增加蛋白质更新为代价。