EFFECT OF CYSTINE INTAKE AND TRACER ADMINISTRATION ON METHIONINE REQUIREMENT

胱氨酸摄入量和示踪剂施用对蛋氨酸需求的影响

• 批准号: 6115551
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6115551
• 关键词: aminoacid metabolism; clinical research; cysteine; cystine; dietary aminoacid; human subject; intravenous administration; methionine; nutrient intake activity; nutrient requirement; nutrition related tag; oral administration; oxidation; radiotracer

To evaluate methionine requirement when cystine is provided by diet. Methionine balance (at requirement intake) will be compared with lower methionine intake plus cystine. By administering orally multi-labeled isotopes of methionine and cysteine, the investigators will be able to obtain information on methionine-cystine cycle and further investigate the cystine sparing role in methionine utilization. During an additional tracer study, tracers will be infused, I.V., to provide information related to the obligatory oxidative losses of methionine and to the efficiency of the utilization of methionine by the human body.

评估饮食提供胱氨酸时的蛋氨酸需求。将蛋氨酸平衡（在需要摄入时）与较低的蛋氨酸摄入量加胱氨酸的比较。 通过给蛋氨酸和半胱氨酸的口服多标记的同位素，研究人员将能够获取有关蛋氨酸 - 囊这周期的信息，并进一步研究甲氨酸利用中的胱氨酸弹性作用。 在一项额外的示踪剂研究中，将注入示踪剂，以提供与蛋氨酸的强制性氧化损失以及人体利用蛋氨酸的效率有关的信息。