LEUCINE & LYSINE: EFFECT OF TRACER PARTITIONING & DIETARY INDISPENSABLE NITROGEN

亮氨酸

• 批准号: 6305669
• 负责人: VERNON R YOUNG
• 金额: $ 4.04万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-12-01 至 2001-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6305669
• 关键词: clinical research; eating; fasting; human subject; leucine; lysine; nitrogen balance; nutrient requirement; nutrition related tag; radiotracer

Study A: We hypothesize that a different partitioning of leucine and lysine tracers, between fast and fed states, would generate data that would not compromise, significantly, our previous understanding and experimental findings that leucine and lysine requirements as defined by FAO/WHO/UNU (1985) are too low. Hence, we expect further support to the MIT-generated values of dietary IAA minimum requirements. Study B: We hypothesize that a decline in dietary IAAs (from "generous" [studied previously] to "intermediate" levels, at a constant total N intake of 160 mg N/kg/d, would not affect significantly leucine and lysine balances and requirements which would be expected to be similar to those described in our previous studies (MIT leucine requirement at 40 mg/kg/d, and lyine at 30 mg/kg/d).

研究A：我们假设在快速和联邦状态之间对亮氨酸和赖氨酸示踪剂的不同分配将产生不会损害的数据，这是我们以前的理解和实验发现，而亮氨酸和实验性发现是FAO/WHO/WHO/UNU（1985）所定义的亮氨酸和赖氨酸的需求。 因此，我们希望进一步支持MIT生成的IAA最低要求的价值。研究B：我们假设饮食中的下降（从先前的“慷慨”到“中间”到“中间”水平，以160 mg N/kg/d的恒定总摄入水平，将不会影响明显的亮氨酸和赖氨酸和赖氨酸平衡和需求，这些平衡和需求与以前的研究中所描述的那些在40 mg/kg/kg/kg/kg/kg/kg/kg中所描述的相似。