CHRONIC DISEASE RISKS ASSOCIATED WITH MERCURY VAPOR EXPOSURE

与汞蒸气接触相关的慢性疾病风险

• 批准号: 6289999
• 负责人: Andrew S. Rowland
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6289999
• 关键词: chronic renal failure; clinical research; dental amalgam; disease /disorder proneness /risk; environmental toxicology; human data; human subject; hypertension; hypothalamic pituitary axis; laboratory rat; mercury poisoning; nitrous oxide; occupational health /safety; ovary disorder

Summary of Work: We are collaborating with researchers from the National Institute of Diabetes and Digestive and Kidney Diseases and the American Dental Association of the risk of end stage renal disease among dentists exposed to mercury and nitrous oxide. We are comparing 138,000 U.S. dentists who graduated before 1977 with the U.S. renal disease registry to see whether general dentists who are highly exposed to mercury have higher rates of renal failure than orthodontists and other subspecialties who have lower exposures. We will also look whether oral surgeons and pedodontists who have elevated nitrous oxide exposures have increased rates. Initial analyses suggest that there is an excess risk of ESRD among general dentists compared to dental specialists which is consistent with the study hypothesis. We are writing up the results of the ESRD study and an earlier study looking at the relationship between dental amalgam and blood pressure using NHANES I data. - dental, mercury, renal disease, childhood development, hypertension, high blood pressure, mercury vapor, - Human Subjects: Interview, Questionaires, or Surveys Only

工作摘要：我们正在与美国国家糖尿病、消化和肾脏疾病研究所以及美国牙科协会的研究人员合作，研究接触汞和一氧化二氮的牙医患终末期肾病的风险。我们正在将 1977 年之前毕业的 138,000 名美国牙医与美国肾脏疾病登记处进行比较，以了解高度接触汞的普通牙医是否比接触较少的正畸医生和其他专科医师有更高的肾衰竭率。我们还将研究一氧化二氮暴露量增加的口腔外科医生和牙科医生的发病率是否有所增加。初步分析表明，与牙科专家相比，普通牙医患 ESRD 的风险较高，这与研究假设一致。我们正在撰写 ESRD 研究的结果以及一项早期研究的结果，该研究利用 NHANES I 数据探讨牙科汞合金与血压之间的关系。 - 牙科、汞、肾病、儿童发育、高血压、汞蒸气 - 人类受试者：仅限访谈、问卷或调查