Reinforcing dental adhesives with monomers capable dynamic rearrangement and self-recovery

使用具有动态重排和自我恢复能力的单体增强牙科粘合剂

• 批准号: 10625355
• 负责人: Caroline Rose Szczepanski
• 金额: $ 15.68万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10625355
• 关键词: 3-Dimensional; Acceleration; Address; Adhesives; Amalgam; Appearance; Appointment; Award; Bacteria; Behavior; Biocompatible Materials; Biological; Bone Tissue; Catechols; Categories; Chicago; Clinical; Complement; Complex; Dental Materials; Dental Schools; Dentin; Development; Development Plans; Ensure; Environment; Esthetics; Exposure to; Failure; Fatigue; Formulation; Funding; Goals; Growth; Healthcare; Heterogeneity; Hybrids; Hydrogen Bonding; Illinois; Infiltration; Institution; Investigation; Laboratory Research; Longevity; Mechanical Stress; Mechanics; Medicine; Mentors; Mentorship; Methacrylates; Michigan; Modeling; Morphology; National Institute of Dental and Craniofacial Research; Oral; Patient Care; Patients; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Postdoctoral Fellow; Predisposition; Protocols documentation; Pyrimidinones; Recovery; Relaxation; Research; Research Personnel; Research Project Grants; Route; Science; Series; Specimen; Stress; Structure; System; Testing; Training; United States; United States National Institutes of Health; Universities; Water; Work; adhesive polymer; analog; biomaterial compatibility; career; career development; chemical group; composite restoration; cost; dental adhesive; design; driving force; efficacy evaluation; improved; innovation; mechanical properties; monomer; novel; oral care; photopolymerization; polymerization; programs; research and development; response; responsible research conduct; restoration; restorative dentistry; restorative material; skills; success; uptake; 3-Dimensional; Acceleration; Address; Adhesives; Amalgam; Appearance; Appointment; Award; Bacteria; Behavior; Biocompatible Materials; Biological; Bone Tissue; Catechols; Categories; Chicago; Clinical; Complement; Complex; Dental Materials; Dental Schools; Dentin; Development; Development Plans; Ensure; Environment; Esthetics; Exposure to; Failure; Fatigue; Formulation; Funding; Goals; Growth; Healthcare; Heterogeneity; Hybrids; Hydrogen Bonding; Illinois; Infiltration; Institution; Investigation; Laboratory Research; Longevity; Mechanical Stress; Mechanics; Medicine; Mentors; Mentorship; Methacrylates; Michigan; Modeling; Morphology; National Institute of Dental and Craniofacial Research; Oral; Patient Care; Patients; Performance; Phase; Plant Resins; Polymers; Positioning Attribute; Postdoctoral Fellow; Predisposition; Protocols documentation; Pyrimidinones; Recovery; Relaxation; Research; Research Personnel; Research Project Grants; Route; Science; Series; Specimen; Stress; Structure; System; Testing; Training; United States; United States National Institutes of Health; Universities; Water; Work; adhesive polymer; analog; biomaterial compatibility; career; career development; chemical group; composite restoration; cost; dental adhesive; design; driving force; efficacy evaluation; improved; innovation; mechanical properties; monomer; novel; oral care; photopolymerization; polymerization; programs; research and development; response; responsible research conduct; restoration; restorative dentistry; restorative material; skills; success; uptake

Project Summary The long-term goal of the award applicant is to establish a competitive, independently funded research program that develops robust materials to address healthcare challenges. This goal will be realized through the execution of an organized, thorough, and integrated career development plan, effective mentorship, and an engaging and innovative research project. The proposed research project will investigate phase separation in self-etch adhesive resins and explore the use of monomers capable of adaptable, dynamic hydrogen bonding to improve overall adhesive performance. The three aims of this project will address the hypothesis that phase separation during adhesive polymerization forms weakened domains of the hybrid layer, which must be reinforced to ensure robust adhesive performance. To this end, the first goal of the research project is to study phase separation in model self-etch adhesives and to ascertain the resulting composition and morphology of heterogeneous domains that result during polymerization. The second goal of the research project is to develop a series of methacrylate monomers decorated with two different hydrogen bonding groups (catechol, and ureido-4[1H]-pyrimidinone – UPy) and ascertain their performance in adhesive resins and efficacy at rearranging in response to applied stresses. The career development proposed for Dr. Caroline Szczepanski includes training in relevant experimental protocols to assess the performance, biocompatibility, and stability of polymeric materials intended for oral care. Additionally, broad training in skills necessary for the management of an independent career and funded research laboratory (e.g. grantsmanship, lab management) will be addressed. These goals are complemented by the choice of mentors and the institutional environment which will all assist in providing the skills and guidance needed by the applicant to develop a successful research program and succeed as an independent investigator. The mentor team will consist of Prof. Ana Bedran-Russo (University of Illinois Chicago – UIC), Prof. Christina Chan (Michigan State University - MSU) and Prof. Marco Bottino (University of Michigan). Profs. Bedran-Russo and Bottino will provide critical guidance and training in the analysis of material performance in simulated oral environments (e.g. micro-tensile bond testing), as well as the use of dentin specimens to assess adhesive efficacy. Since both Profs. Bedran-Russo and Bottino are affiliated with schools of dental medicine, they will also provide Dr. Szczepanski with opportunities to attend research seminars, meet fellow researchers, and network within this new field of research. Prof. Chan will provide mentorship particularly focused on grantsmanship as well as navigating the path towards reappointment and tenure at MSU. In addition to these mentors, Dr. Szczepanski’s career development plan includes seminars in the grantsmanship, responsible conduct of research, and mentorship will be pursued throughout the award period. Together, the proposed research and career development plan will build upon the applicant’s expertise in polymer science to situate themselves as a significant contributor to NIDCR and NIH relevant research.

项目摘要 奖励申请人的长期目标是建立竞争性，独立资助的研究计划 这会开发出强大的材料来应对医疗保健挑战。该目标将通过执行实现 有组织，彻底且综合的职业发展计划，有效的精神训练以及引人入胜的和 创新研究项目。拟议的研究项目将研究自我蚀刻的阶段分离 粘合剂树脂并探索能够适应性动态氢键以改进的单体的使用 总体粘合性能。该项目的三个目标将解决相位分离的假设 在粘合性聚合过程中形成杂种层的弱域，必须加固以确保 强大的粘合性能。为此，研究项目的第一个目标是研究阶段分离 建模自我蚀刻粘合剂并确定异质域的产生组成和形态 在聚合过程中的结果。研究项目的第二个目标是开发一系列甲基丙烯酸酯 单体用两个不同的氢键组（Catechol和Ureido-4 [1H] - 吡啶酮酮 - upy）并确定它们在粘合剂响应中的性能，并在重排时轻松响应 压力。为Caroline Szczepanski博士提出的职业发展包括相关的培训 评估聚合材料的性能，生物相容性和稳定性的实验协议 进行口腔护理。此外，在管理独立职业所必需的技能方面进行的广泛培训和 将解决资助的研究实验室（例如授予技巧，实验室管理）。这些目标是 由导师的选择和机构环境完成的，所有这些都将有助于提供 申请人需要制定成功的研究计划并成功地担任的技能和指导 独立研究者。导师团队将由Ana Bedran-Russo教授（伊利诺伊大学芝加哥大学）组成 - UIC），Christina Chan教授（密歇根州立大学 - 密西根州立大学）和Marco Bottino教授（密歇根大学）。 教授。 Bedran-Russo和Bottino将在分析材料的分析中提供关键的指导和培训 在模拟的口服环境（例如微张紧键测试）中的性能以及牙本质的使用 标本评估粘合剂效率。由于两个教授。 Bedran-Russo和Bottino与学校有关联 在牙科医学上，他们还将为Szczepanski博士提供参加研究中心的机会，见面 研究人员和网络在这个新的研究领域中。 Chan教授将特别提供指导 专注于授予技巧以及导航MSU重新任命和任期的道路。此外 对于这些导师，Szczepanski博士的职业发展计划包括赠款中的下水道， 在整个奖励期间，将继续进行负责任的研究和精神训练。在一起， 拟议的研究和职业发展计划将基于申请人在聚合物科学方面的专业知识，以 将自己作为NIDCR和NIH相关研究的重要贡献。