EFFECTS OF DENTAL TREATMENT DURING PREGNANCY ON CHILDHOOD DEVELOPMENT

怀孕期间牙科治疗对儿童发育的影响

• 批准号: 6106699
• 负责人: Andrew S. Rowland
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6106699
• 关键词: child physical development; child psychology; clinical research; embryo /fetus toxicology; epidemiology; human data; longitudinal human study; mercury poisoning; oral health

Summary of Work: The Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC) is a unique prospective of pregnancy in which 14,000 mother's were enrolled when they first became pregnant and now their children have continued to be followed as they approach school age. We are collaborating with researchers from the ALSPAC study on a study of the effect of having dental work done during pregnancy on subsequent childhood development. In Great Britain, many women receive extra dental care during pregnancy when their insurance coverage is increased. Mercury vapor can cross the placenta but it is not known whether there are any adverse effects on the fetus. Having dental work done during pregnancy could also affect the fetus by spreading infection through the bloodstream. We recently received a data set that we will use to look at the effect of dental treatment during pregnancy on infant development. The data set contains questions on motor and cognitive milestones adapted from the Denver Developmental Screening Test,on temperament and behavior that were adapted from the Carey Infant temperament Questionnaire, and speech and language development adapted from the McCarthur infant communication questionnaire. On about 1500 of the children, we will also have data on the mercury levels in the umbilical cord itself. We looked for predictors of cord mercury levels and using regression models found that fish consumption, having 4 or more amalgams in one's mouth and having dental work done during pregnancy were related to increased cord mercury levels. This is one of the first studies to use cord mercury levels as a marker for mercury vapor exposure (it had been used before as a marker of methyl mercury).

工作总结：雅芳纵向研究 怀孕和儿童 (ALSPAC) 是一个独特的前景 14,000 名母亲第一次怀孕时就登记了 怀孕了，现在他们的孩子还在继续 当他们接近学龄时。我们正在合作 ASPAC 研究人员对以下因素的影响进行了研究： 在怀孕期间进行牙科治疗 童年发展。在英国，许多女性接受 当其保险范围为怀孕期间的额外牙科护理 增加。汞蒸气可以穿过胎盘，但目前尚不清楚 是否对胎儿有不良影响。有牙科 怀孕期间所做的工作也会影响胎儿 通过血液传播感染。我们最近收到 我们将用来观察牙科治疗效果的数据集 怀孕期间对婴儿发育的影响。数据集包含 关于运动和认知里程碑的问题改编自 丹佛发育筛查测试，关于气质和 根据凯里婴儿气质改编的行为 问卷以及言语和语言发展改编自 麦卡瑟婴儿沟通问卷。约1500 对于儿童，我们还将获得有关儿童体内汞含量的数据 脐带本身。我们寻找脐带汞的预测因子 水平并使用回归模型发现鱼类消费， 口中含有 4 种或以上汞合金并进行牙科治疗 怀孕期间进行的操作与脐带汞含量增加有关 水平。这是最早使用脐带汞含量作为衡量指标的研究之一 汞蒸气暴露标记（以前曾被用作汞蒸气暴露标记） 甲基汞标记）。