INTRA-CORTICAL NEURO RECORDING TELEMETER

皮质内神经记录遥测仪

• 批准号: 2842433
• 负责人: DAVID J EDELL
• 金额: $ 28.96万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2842433
• 关键词: Macaca mulatta; bioengineering /biomedical engineering; brain electrical activity; cats; dogs; electrodes; electronic recording system; implant; laboratory rabbit; medical implant science; microelectrodes; neuroanatomy; neurophysiology; pia mater; technology /technique development; telemetry

A new technology will be developed for long term neural recordings using intra-cortical microelectrode arrays. One important desired feature of long-term neural recordings is the ability to record from the same neurons from month to month or year to year. However, with existing technology this is very difficult to accomplish. One possible reason may be motion of the microelectrode array relative to the neural tissue caused by wiring from the arrays to the skull. A small, lightweight, wireless neural recording telemeter embedded in the pia so it could move with the brain may exhibit improved capacity for reproducibly recording from single units for long times. The objective of the proposed work is to develop and evaluate a tetherless, small, lightweight 16-channel telemeter. This telemeter will be attached directly to intra-cortical microelectrode arrays for placement on the pia. The packaging will be of the appropriate materials and shape to encourage encapsulation and stabilization by the pia. Data and power will be telemetered through the skull to external instrumentation. Rabbit, dog, cat and monkey will be used as animal models in this study to evaluate the technology in a variety of circumstances and with a variety of existing protocols. Metrics of the technology include: long term assessment of the electrical properties of the system; length of time that single units can be maintained; amplitude stability of single units over time; neuron density about the microelectrodes; degree of encapsulation by the pia; migration distance of the microelectrodes; and evidence of micro-hemorrhages. The primary application of this technology will be to facilitate long term intra-cortical chronic recordings for neuroscience. Perhaps when the technology is fully developed, it will be possible to apply it to rehabilitation of the spinal cord injured. An example would be for extraction of motor control information for control of functional electrical stimulation systems.

将开发一种使用皮质内微电极阵列进行长期神经记录的新技术。 长期神经记录的一个重要的期望特征是能够逐月或逐年从相同的神经元进行记录。 然而，利用现有技术这是很难实现的。 一种可能的原因可能是微电极阵列相对于神经组织的运动，这是由从阵列到头骨的接线引起的。 嵌入软脑膜中的小型、轻质、无线神经记录遥测仪可以与大脑一起移动，从而可以提高单个单元长时间可重复记录的能力。拟议工作的目标是开发和评估一种无线、小型、轻型 16 通道遥测仪。 该遥测仪将直接连接到皮层内微电极阵列，以放置在软脑膜上。 包装将采用适当的材料和形状，以促进 pia 的封装和稳定。 数据和电力将通过头骨遥测到外部仪器。本研究将使用兔子、狗、猫和猴子作为动物模型，以在各种情况下和各种现有协议下评估该技术。 该技术的指标包括：系统电气特性的长期评估；单个单元可以维持的时间长度；单个单元随时间变化的幅度稳定性；微电极周围的神经元密度； pia的封装程度；微电极的迁移距离；以及微出血的证据。该技术的主要应用将是促进神经科学的长期皮质内慢性记录。也许当这项技术成熟后，就有可能将其应用于脊髓损伤的康复。 一个例子是提取运动控制信息以控制功能性电刺激系统。