Liquid Crystal Polymer Substrate IntraCochlear Electrode

液晶聚合物基底耳蜗内电极

• 批准号: 6585330
• 负责人: DAVID J EDELL
• 金额: $ 11.56万
• 依托单位: INNERSEA TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-10 至 2004-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6585330
• 关键词: animal tissue; biological models; biomaterial development /preparation; biomaterial evaluation; biomaterial interface interaction; cochlear implants; electrical property; electrodes; electrophysiology; human tissue; liquid crystal; medical implant science; neural conduction; polymers; telemetry; tympanum

DESCRIPTION (provided by applicant): This is a technology development proposal that will create a new technology base for cochlear electrodes. The goal is to produce a micro-machined, multi-contact electrode array using a biocompatible, bioresistant, dimensionally stable, polymer substrate Because this polymer substrate is dimensionally stable, thin metal traces can be micro-machined for electrode contacts and interconnects The resulting electrode array can be as thin as 25mm, less than 0 5mm wide and very flexible. With this small, flexible array as a beginning point, the mechanical aspects at every point along the length of the complete intra-cochlear implant can be specified and optimized. These mechanical characteristics of shape, springiness, and flexibility in two planes determine the probability of trauma during surgical insertion. Thus, an electrode with idealized mechanical properties will result in less trauma Benefits of this new technology would also include improved electrode positioning necessary for more efficient coupling to the residual neural elements, a larger number of electrode contacts and possibly deeper insertion into the lower frequency portions of the cochlea. Goals of Phase I are design and fabrication of several iterations of electrode carriers and electrode arrays, mechanical structuring of the arrays, and saline soak testing for electrical properties. In preparation for Phase II, an implantable integrated circuit diagnostic stimulator for detailed study of the assembly stability under realistic chronic implant conditions in-vitro and in-vivo will be developed. Phase II research will involve further optimization of the intracochlear electrode arrays based on results of extensive in-vivo measurements of performance using CNS recording paradigms at UCSF and analysis of insertion trauma in cat and human cadaver material. Long-term reliability of the technology will be evaluated in-vitro and in-vivo using the implantable diagnostic stimulator. An integrated circuit stimulator will be developed based on results of the diagnostic stimulator and embedded within the terminal portion of the polymer substrate. This new, robust, intracochlear implant will be useful for advanced chronic physiology studies and clinical application.

描述（由申请人提供）：这是一项技术开发提案，将为耳蜗电极创建新技术基础。目标是使用生物相容性、抗生物性、尺寸稳定的聚合物基板生产微机械加工的多触点电极阵列。由于这种聚合物基板尺寸稳定，因此可以对薄金属迹​​线进行微机械加工，用于电极接触和互连。阵列可薄至25mm，宽度小于0 5mm，非常灵活。以这个小型、灵活的阵列为起点，可以指定和优化整个人工耳蜗植入体长度上每个点的机械方面。两个平面上的形状、弹性和柔韧性等机械特性决定了手术插入期间发生创伤的可能性。因此，具有理想机械性能的电极将导致更少的创伤。这项新技术的好处还包括改进电极定位，以更有效地耦合到残余神经元件、更多数量的电极触点以及可能更深地插入较低频率部分耳蜗的。第一阶段的目标是设计和制造电极载体和电极阵列的多次迭代、阵列的机械结构以及电气性能的盐水浸泡测试。在第二阶段的准备过程中，将开发一种可植入集成电路诊断刺激器，用于详细研究体外和体内真实慢性植入条件下的组装稳定性。第二阶段研究将包括根据使用加州大学旧金山分校中枢神经系统记录范式进行的广泛体内性能测量结果以及对猫和人类尸体材料插入创伤的分析，进一步优化耳蜗内电极阵列。该技术的长期可靠性将使用植入式诊断刺激器在体外和体内进行评估。将根据诊断刺激器的结果开发集成电路刺激器并将其嵌入聚合物基板的终端部分内。这种新型、坚固的耳蜗内植入物将有助于高级慢性生理学研究和临床应用。