NNFF Intl Consortium--Molecular Biology of NF1 and NF2

NNFF国际联盟--NF1和NF2的分子生物学

• 批准号: 6359781
• 负责人: Luis Fernando Parada
• 金额: $ 6.85万
• 依托单位: CHILDREN'S TUMOR FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-15 至 2002-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6359781
• 关键词: international health /scientific organization; meeting /conference /symposium; molecular biology; neurofibromatosis; neurofibromatosis type 1 protein /gene; travel

DESCRIPTION (provided by applicant): We request funding for the next meeting of the International Consortium for the Molecular Biology of NF 1 and NF2 to be held May 20-23, 2001 at the hotel Jerome in Aspen Colorado. Under the organization of the National Neurofibromatosis Foundation (NNFF), these Consortium meetings have been held on a yearly basis and have served to consolidate the efforts of cell biologists, molecular biologists, and clinicians. Previous meetings led to the identification and cloning of the NF1 and NF2 genes; and facilitated understanding of their structure and function. Since 1995, the yearly meeting has alternated between a larger open format for which announcement is widespread and includes invitation for submission of abstracts by NF researchers throughout the world and a more limited format, in which specific participants and discussants are invited to participate. This latter format provides opportunity for increased discussion and focussing of strategic plans for the future. This year, we propose to bring in specialists from outside the NF field to evaluate current NF research. These will include leading experts in signal transduction, tumorigenesis, cytoplasm organization, and other areas. Each session will be co-chaired by an NF researcher and an outside specialist whose function will be not only to present a research talk but also to assist in guiding the discussion and evaluating the work in NF as it relates to state of the art approaches in each field. Selection of invited speakers has been made with an effort to include all pertinent areas of NF research with emphasis on recent advances. In six sessions, 4 speakers will be allowed 25 minutes for presentation and an additional 20 minutes for discussion. At the end, the "expert co-chair" will be asked to summarize in the context of the larger picture. To ensure the participation of young investigators, each participant will be invited together with one junior member of their laboratory (graduate student or postdoctoral fellow). We expect this opportunity to stimulate the interest of young scientists to pursue NF research (particularly those coming for the expert co-chair laboratories). We anticipate that this format will emphasize new breakthroughs and serve to identify of critical gaps in current approaches and/or understanding. The overall goal is to improve our understanding of the molecular and cell biology of NF1 with the understanding that advances will have important implications for the treatment of these disorders as well as more wide spread understanding of neuroscience, cancer, and development.

描述（由申请人提供）：我们请求为下一次会议提供资金 国际 NF 1 和 NF 2 分子生物学联盟 2001 年 5 月 20 日至 23 日在科罗拉多州阿斯彭的杰罗姆酒店举行。下 国家神经纤维瘤病基金会 (NNFF) 的组织，这些 联盟会议每年举行一次，并起到了促进作用 凝聚细胞生物学家、分子生物学家和 临床医生。之前的会议导致了 NF1 的鉴定和克隆 和 NF2 基因；并有助于理解它们的结构和功能。 自 1995 年以来，年会在更大规模的开放形式和 该公告已广泛传播，并邀请提交 世界各地 NF 研究人员的摘要以及更有限的格式， 邀请哪些具体参与者和讨论者参加。这 后一种形式为加强讨论和集中讨论提供了机会 未来的战略计划。今年我们建议引进专家 从 NF 领域之外评估当前的 NF 研究。这些将包括 信号转导、肿瘤发生、细胞质组织领域的领先专家， 和其他领域。每场会议将由一名 NF 研究员和一名 外部专家的职责不仅仅是发表研究报告 还协助指导 NF 的讨论和评估工作 它涉及每个领域的最先进方法。选定受邀者 演讲者努力涵盖 NF 的所有相关领域 研究重点是最新进展。在六场会议中，将有 4 位发言人 允许 25 分钟的演示时间和 20 分钟的额外时间 讨论。最后，将请“专家联合主席”在报告中进行总结 更大的背景。为保证青少年的参与 调查员，每位参与者将与一名初级成员一起被邀请 他们的实验室（研究生或博士后）。我们期待这个 激发年轻科学家从事神经网络研究兴趣的机会 （特别是那些来担任专家联合主席实验室的人）。我们预计 这种形式将强调新的突破并有助于确定 当前方法和/或理解中存在严重差距。总体目标是 提高我们对 NF1 分子和细胞生物学的理解 了解进展将对治疗产生重要影响 这些疾病以及对神经科学更广泛的理解， 癌症和发育。