COMBINED RAMAN & FLUORESCENCE METHODS FOR BREAST CANCER DETECTION & IMAGING

组合拉曼

• 批准号: 6281771
• 负责人: RAMASAMY MANOHARAN
• 金额: $ 1.51万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 1999-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281771
• 关键词: biomedical equipment development; biomedical resource; female; human subject; human tissue; infrared radiation; lasers; spectrometry; technology /technique

We are developing two optical methods based on near infrared Raman spectroscopy and fluorescence photon migration for breast cancer diagnosis and imaging. Raman spectroscopy, an in situ technique for histochemical analysis, can be implemented via a fiber optic needle probe inserted into breast as part of needle aspiration or core biopsy. Fluorescence photon migration is being developed as an optical tomographic technique for localizing lesions. We envision that the two techniques can be integrated, with fluorescence imaging first to used to localize a suspicious lesion, and Raman information, obtained by passing a fiber optic probe through a biopsy needle, then used for accurate diagnosis. In the current year, we demonstrated the ability of Raman to classify accurately normal, benign, and malignant tissues by utilizing 830 nm light. We also showed that photon migration imaging can be used to localize accurately small fluorescent objects imbedded in a thick trubid m edium with realistic optical properties, thus demonstrating the potential of this technique for optical imaging.

我们正在开发两种基于近红外拉曼的光学方法 乳腺癌的光谱和荧光光子迁移 诊断和成像。 拉曼光谱，一种原位技术 组织化学分析可以通过光纤针头实施 作为针头或核心的一部分插入乳房的探针 活检。 荧光光子迁移正在发展为 用于定位病变的光学断层扫描技术。 我们设想 可以通过荧光成像整合两种技术 首先用来定位可疑病变和拉曼信息， 通过将光纤探针通过活检针头获得 用于准确诊断。 在今年，我们证明了 拉曼能够准确地对正常，良性和恶性分类 通过利用830 nm的光进行组织。 我们还显示了光子 迁移成像可用于精确定位小荧光 物体嵌入厚的trubid m edium，具有逼真的光学 属性，从而证明了该技术的潜力 光学成像。