FLUORESCENCE EEM SPECTROSCOPY FOR DETECTION OF DYSPLASIA IN EPITHELIAL TISSUES

用于检测上皮组织发育不良的荧光 EEM 光谱

• 批准号: 6314212
• 负责人: RAMASAMY MANOHARAN
• 金额: $ 1.38万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6314212
• 关键词: biomedical equipment development; biomedical resource; human tissue; oral pharyngeal; technology /technique; urinary tract

We have developed in vivo EEM system which can collect 10 fluorescence spectra excited with 10 different light sources and diffuse reflectance spectra from the same tissue in less than a second. This system is currently being used to study precancerous changes in Barrett's esophagus and colon. So far we have examined nearly 55 patients undergoing surveillance for dysplasia in Barrett's esophagus. The system is also being used at the Brigham and Women's Hospital for studying adenomatous polyps and dysplasia in colon. The wealth of fluorescence information provided by rapid EEM system is being analyzed using model based approach and principal component analysis approach.

我们已经开发了可以收集10的体内EEM系统 用10种不同的光源激发的荧光光谱和 从小于A 第二。 该系统目前正在用于研究癌前 巴雷特食管和结肠的变化。 到目前为止，我们已经检查了 巴雷特的近55名患者正在接受监测的不适当。 食管。 该系统也在杨百翰和女性使用 在结肠研究腺瘤息肉和发育不良的医院。 这 快速EEM系统提供的大量荧光信息是 使用基于模型的方法和主组件​​进行分析 分析方法。