SEROTONIN AND AGGRESSION IN COCAINE DEPENDENCE

可卡因依赖中的血清素和攻击性

• 批准号: 2770088
• 负责人: FREDERICK Gerard MOELLER
• 金额: $ 22.24万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-20 至 2000-04-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2770088
• 关键词: adrenocorticotropic hormone; aggression; antisocial personality; behavioral /social science research tag; buspirone; clinical research; cocaine; comorbidity; cortisol; drug addiction; drug withdrawal; gender difference; high performance liquid chromatography; human subject; impulsive behavior; radioimmunoassay; serotonin; serotonin inhibitor; serotonin receptor; serotonin transporter

DESCRIPTION: (Applicant's Abstract) Cocaine dependence and violence are serious public health problems that are often related. There are many biological features of these behaviors that are poorly understood. Further research will elucidate mechanisms and contribute to the development of more effective treatments for impulsive behaviors including cocaine use and the associated violence. Low serotonin (5-HT) function is associated with increased aggressive and impulsive behavior in individuals with antisocial personality disorder (ASP). These same individuals have a high probability of substance dependence. Thus, the association between substance abuse and impulsive and aggressive behavior is complex and may be influenced both by the pharmacologic effects of drugs themselves and the fact that individuals who abuse drugs are also more prone to these behaviors. Although some studies find that cocaine increases aggressive behavior in laboratory animals most animal studies do not find an increase in aggression after cocaine administration. Epidemiological studies find an association between cocaine and violence, but few laboratory studies have examined this issue in humans. In preliminary studies by our group, we have found evidence that some individuals (with ASP) may be more prone to aggression induced by chronic cocaine use. Thus, it is possible that preexisting characteristics of an individual (such as low 5-HT function) interact with the pharmacologic effects of chronic cocaine use to increase impulsive and aggressive behavior. The specific aims of this proposal are: Aim: 1. To determine the effects of recent chronic cocaine use and cocaine abstinence/withdrawal on impulsive and aggressive responding in female and male cocaine dependent subjects with ASP, and in matched cocaine dependent subjects without ASP and to compare this responding to matched healthy controls. Aim 2. To measure 5-HT function using a neuroendocrine challenge and relate this measure to impulsive and aggressive responding in the same groups of subjects studied in Aim 1. Aim 3. To determine if chronic administration of the 5-HT agonist buspirone decreases impulsive and aggressive responding and cocaine use in subjects with ASP.

描述：（申请人的摘要） 可卡因依赖和暴力是严重的公共卫生问题 经常相关。 这些行为有许多生物学特征 知之甚少。 进一步的研究将阐明机制和 有助于开发更有效的冲动治疗 包括可卡因使用和相关暴力在内的行为。 低羟色胺（5-HT）功能与侵略性增加和 反社会人格障碍患者的冲动行为 （ASP）。 这些相同的人有很高的物质可能性 依赖。 因此，滥用药物与冲动与 侵略性行为很复杂，可能受到 药物本身的药理作用以及个人 滥用药物也更容易出现这些行为。 虽然有一些研究 发现可卡因最大程度地增加了实验动物的侵略性行为 动物研究没有发现可卡因后侵略性增加 行政。 流行病学研究发现可卡因之间存在关联 和暴力，但是很少有实验室研究在人类中检查了这个问题。 在我们小组的初步研究中，我们发现了一些证据表明有些 个体（带有ASP）可能更容易受到慢性诱导的侵略性 可卡因使用。 因此，有可能存在的特征 个体（例如低5-HT功能）与药物相互作用 慢性可卡因用于增加冲动和侵略性的影响 行为。 该提议的具体目的是：目标：1。确定效果 最近的慢性可卡因使用和可卡因的禁欲/戒烟 以及对女性和男性可卡因依赖性受试者的积极反应 ASP，在没有ASP的匹配的可卡因依赖受试者中 这对匹配的健康对照响应。 目标2。使用神经内分泌挑战测量5-HT功能并关联 这项措施以冲动和激进的反应 在AIM 1中研究的受试者。 目标3。确定5-HT激动剂丁螺酮的慢性给药是否 减少冲动和积极反应和可卡因在受试者中的使用 使用ASP。