Center for Clinical and Translational Research

临床和转化研究中心

• 批准号: 10409659
• 负责人: FREDERICK Gerard MOELLER
• 金额: $ 370.39万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-08 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10409659
• 关键词: Advisory Committees; Area; Basic Science; Biomedical Research; Biometry; Caregivers; Caring; Clinical; Clinical Research; Collaborations; Communities; Development; Diagnostic; Disease; Doctor of Medicine; Educational Models; Endowment; Environment; Fostering; Funding; Gifts; Goals; Health Care Research; Health Sciences; Health system; Informatics; Institute of Medicine (U.S.); Institution; Institutional support resources; Longevity; Methods; Mining; National Center for Advancing Translational Sciences; Patients; Performance; Phase; Pilot Projects; Process; Provider; Reporting; Research; Research Design; Research Infrastructure; Research Methodology; Resources; Role; Science; Scientist; Source; Special Population; Speed; System; Therapeutic; Training; Translating; Translational Research; Translations; United States; Universities; Virginia; Workforce Development; base; biomedical informatics; clinical center; clinical practice; community engagement; data warehouse; doctoral student; experience; human subject protection; improved; informatics tool; innovation; insight; large datasets; medical schools; multiple data types; next generation; operation; patient population; preventive intervention; programs; recruit; senior faculty

Contact PD/PI: MOELLER, FREDERICK Gerard The Center for Clinical and Translational Research (CCTR) at Virginia Commonwealth University (VCU) promotes clinical and translational research (CTR), moving research advances from basic science into clinical practice, and improving the quality and efficiency of clinical research. Over the last 5 years the CCTR has become a critical component of VCU’s clinical and translational research environment. The value placed on the CCTR’s role in advancing clinical research is evidenced by over $43,000,000 of institutional support, including a recent $16 million gift to rename the CCTR the C. Kenneth and Dianne Wright Center for Clinical and Translational Research. In addition, the CCTR serves as the only CTSA funded hub in Virginia, fostering statewide and national collaborations in clinical and translational research in areas of human subjects protection and recruitment, community engagement, team science, informatics, and scientific review. The overall CCTR strategic goal is to catalyze CTR through programs and processes that enhance quality and efficiency, integrate research and clinical practice, and provide training to develop the CTR workforce. This goal will be achieved in collaboration with the CTSA Network and implemented at VCU and our partner institutions locally, regionally, and nationally, as described in detail related to each overall aim below. An important theme across cores is innovation in methods for processing, analysis, mining, integrating, and sharing of large data sets. Overall Aim 1: Promote translational research workforce development with experience based training in informatics, team science, biostatistics, research design, and regulatory science, sharing and collaborating with the CTSA Network in best educational practices to develop the next generation of CTR scientists. Overall Aim 2: Mobilize existing strengths in community engagement and team science to engage stakeholder communities at every translational phase to become research partners and form collaborative clinical translational science teams. Overall Aim 3: Integrate all phases of CTR across the lifespan and in special populations by increasing hub and network research capacity and connecting with relevant providers, patients, caregivers, and other stakeholders to guide research, care, and recruitment. Overall Aim 4: Advance clinical and translational research methods and processes to speed translation, build collaborations, and optimize resources within VCU and with the CTSA Network. Overall Aim 5: Implement informatics systems to integrate multiple types of data to gain insight into diseases and mechanisms, to enhance training, to collect metrics to improve performance and gauge impact, and to bridge research to clinical practice across the CCTR and the CTSA Network. Project Summary/Abstract Page 227 Contact PD/PI: MOELLER, FREDERICK Gerard As described in the Institute of Medicine (IOM) report on the CTSA program, although there has been an exponential increase in biomedical research in the United States in the last 50 years, translating the findings from basic and clinical research to clinical practice has fallen short. For the next 5 years of funding, the CCTR proposes to capitalize on strengths in a special patient population, community engagement, workforce development, and informatics, to expand connections with the CTSA network to promote innovation in methods, processes, and training, focused on the delivery of high quality clinical and translational research. In addition, utilizing biomedical informatics tools, the CCTR will promote a greater integration of healthcare and research within VCU and across statewide and national partners.

联系PD/PI：Moeller，Frederick Gerard 弗吉尼亚联邦大学（VCU）的临床与转化研究中心（CCTR） 促进临床和翻译研究（CTR），将研究从基础科学发展为 临床实践，并提高临床研究的质量和效率。在过去的五年中 CCTR已成为VCU临床和翻译研究环境的关键组成部分。值 超过4300万美元的机构证明了CCTR在进行临床研究中的作用。 支持，包括最近的1600万美元礼物，将CCTR重命名为C. Kenneth和Dianne Wright Center for 临床和翻译研究。此外，CCTR是弗吉尼亚州唯一的CTSA资助枢纽 在全州和全国性的临床和翻译研究领域的研究中培养人类受试者的研究 保护和招聘，社区参与，团队科学，信息信息和科学评论。 CCTR的总体战略目标是通过增强的程序和流程催化CTR 质量和效率，综合研究和临床实践，并提供培训以开发CTR 劳动力。该目标将与CTSA网络合作实现，并在VCU和我们的 合作伙伴机构在本地，区域和全国范围内，如下所述，详细描述了下面的每个整体目标。 跨核心的一个重要主题是用于处理，分析，采矿，整合和 共享大数据集。 总体目标1：以经验为基础的转化研究劳动力发展 分享信息，团队科学，生物统计学，研究设计和监管科学的培训，分享 并与最佳教育实践中的CTSA网络合作开发下一代 CTR科学家。 总体目标2：动员社区参与和团队科学的现有优势 在每个翻译阶段与利益相关者社区互动，成为研究伙伴并形成 协作临床转化科学团队。 总体目的3：整合整个寿命的CTR的所有阶段，以及在特殊人群中通过 增加集线器和网络研究能力，并与相关提供者，患者， 护理人员和其他利益相关者指导研究，护理和招聘。 总体目标4：提前临床和翻译的研究方法和过程，以加快速度 翻译，建立协作并优化VCU和CTSA网络中的资源。 总体目标5：实施信息系统以整合多种类型的数据以获得洞察力 进入疾病和机制，增强培训，收集指标以提高性能和 衡量影响，并在整个CCTR和CTSA网络上桥接研究。 项目摘要/摘要页面227 联系PD/PI：Moeller，Frederick Gerard 如医学研究所（IOM）关于CTSA计划的报告，尽管有一个 在过去50年中，美国生物医学研究的指数增长，转化了发现 从基础和临床研究到临床实践的缺点。在接下来的5年资金中，CCTR 提议在特殊患者群体，社区参与，劳动力中利用优势的提议 开发和信息信息，以扩大与CTSA网络的联系，以促进创新 方法，过程和培训的重点是提供高质量的临床和翻译研究。在 此外，使用生物医学信息工具，CCTR将促进医疗保健和 VCU内以及各州和国家合作伙伴的研究。

项目成果

Intimate Partner Violence and Mental Health Among Transgender/Gender Nonconforming Adults.

• DOI: 10.1177/0886260518775148
• 发表时间: 2021-04
• 期刊: Journal of interpersonal violence
• 影响因子: 2.5
• 作者: Henry RS;Perrin PB;Coston BM;Calton JM
• 通讯作者: Calton JM

Physical Therapy Use, Costs, and Value for Latent Classes of Good vs Poor Outcome in Patients Who Catastrophize About Their Pain Prior to Knee Arthroplasty.

• DOI: 10.1016/j.apmr.2021.02.004
• 发表时间: 2021-07
• 期刊: Archives of physical medicine and rehabilitation
• 影响因子: 4.3
• 作者: Orndahl CM;Perera RA;Hung A;Dumenci L;Riddle DL
• 通讯作者: Riddle DL

Evidence of Neutralizing and Non-Neutralizing Anti-Glucosaminidase Antibodies in Patients With S. Aureus Osteomyelitis and Their Association With Clinical Outcome Following Surgery in a Clinical Pilot.

• DOI: 10.3389/fcimb.2022.876898
• 发表时间: 2022
• 期刊: Frontiers in cellular and infection microbiology
• 影响因子: 5.7

Fibrosis-4 Predicts the Need for Mechanical Ventilation in a National Multiethnic Cohort of Corona Virus Disease 2019.

• DOI: 10.1002/hep4.1737
• 发表时间: 2021-09
• 期刊: Hepatology communications
• 影响因子: 5.1
• 作者: Sterling RK;Shin D;Shin Y;French E;Stevens MP;Bajaj JS;DeWit M;Sanyal AJ
• 通讯作者: Sanyal AJ

Transcriptomic changes underlying EGFR inhibitor resistance in human and mouse models of basal-like breast cancer.

• DOI: 10.1038/s41598-022-25541-3
• 发表时间: 2022-12-08
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Rashid NS;Boyd DC;Olex AL;Grible JM;Duong AK;Alzubi MA;Altman JE;Leftwich TJ;Valentine AD;Hairr NS;Zboril EK;Smith TM Jr;Pfefferle AD;Dozmorov MG;Harrell JC
• 通讯作者: Harrell JC