N3C & All of Us Research Program Collaborative Project

N3C

• 批准号: 10217339
• 负责人: FREDERICK Gerard MOELLER
• 金额: $ 34.66万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-22 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10217339
• 关键词: Administrative Supplement; All of Us Research Program; COVID-19; COVID-19 pandemic; Clinical; Clinical Data; Clinical Research; Clinical Trials; Collaborations; Communities; Community Outreach; Consent; Data; Data Analyses; Data Set; Development; Diagnosis; Disease; Ecosystem; Effectiveness; Funding Opportunities; Goals; Health; Health Status; Individual; Informatics; Infrastructure; Institution; Laboratories; Outcomes Research; Participant; Pathway interactions; Patients; Pharmaceutical Preparations; Population; Positioning Attribute; Procedures; Public Health; Research; Research Personnel; Resource Informatics; Resources; Services; Supervision; Testing; Translational Research; United States National Institutes of Health; base; biomedical informatics; clinical center; cohort; coronavirus disease; data resource; data sharing; data standards; data warehouse; demographics; design; improved; informatics infrastructure; innovation; large scale data; multi-site trial; network informatics; open data; pandemic disease; parent grant; programs; recruit; response; statistical and machine learning; tool

Project Summary/Abstract The COVID-19 pandemic presents unprecedented clinical and public health challenges. Though institutions collect large amounts of clinical data about COVID-19 cases, these datasets individually might not be diverse enough to draw population level conclusions. Also, statistical, machine learning, and causal analyses are most successful with large-scale data beyond what is available in any given organization. To tackle this problem, NCATS introduced the National COVID Cohort Collaborative (N3C), an open science, community-based initiative to share patient level data for analysis. The initiative requires participating institutions to share information about their COVID-19 patients in a standard-driven way, including demographics, vital signs, diagnoses, laboratory results, medications, and other treatments. The data from multiple institutions will be merged and consolidated, and access will be provided to investigators through a centralized analytical platform. The COVID-19 data sharing collaboration with the N3C initiative offers a mechanism to initiate collaborations with other NIH sponsored data sharing programs, such as the All of Us Research Program (AoURP). This administrative supplement will support efforts to clean and standardize data at VCU, and to transfer it to the N3C data repository. The supplement will also assist in introducing new services at the Wright Center to support our investigators to use the N3C resources. It will also enable collaboration with the AoURP by establishing a pipeline to collect and transmit consented patients' EHR data and by building on existing community outreach pathways to recruit additional participants for the AoURP. The project will be overseen by the PI/Executive Committee and supervised by the Director of Research Informatics. Procedures and services developed at our local CTSA hub will be shared and disseminated to the CTSA network.

项目摘要/摘要 COVID-19大流行提出了前所未有的临床和公共卫生挑战。虽然机构 收集大量有关COVID-19病例的临床数据，这些数据集可能并非不同 足以得出人口水平的结论。此外，统计，机器学习和因果分析是最多的 超出任何给定组织中可用的大型数据成功。要解决这个问题， NCAT引入了国家Covid队列合作（N3C），这是一项开放科学，基于社区的倡议 共享患者级别的数据进行分析。该倡议要求参与的机构共享有关的信息 他们以标准驱动方式以人口统计学，生命体征，诊断，实验室的方式以标准驱动方式的19例患者 结果，药物和其他治疗方法。来自多个机构的数据将合并和合并， 并将通过集中的分析平台向调查人员提供访问。 COVID-19数据 与N3C计划共享合作提供了一种与其他NIH合作的机制 赞助的数据共享计划，例如美国所有研究计划（AOURP）。 这种行政补充剂将支持在VCU清洁和标准化数据的努力，并转移 它到N3C数据存储库。该补充剂还将协助在赖特（Wright）引入新服务 支持我们的调查人员使用N3C资源的中心。它还将与 通过建立一条管道来收集和传输同意患者的EHR数据并建立aourp 关于现有的社区外展途径，招募了AOURP的其他参与者。项目 将由PI/执行委员会监督，并由研究信息学主管监督。 在我们当地的CTSA中心开发的程序和服务将分享并传播到CTSA 网络。