PERCEPTUAL MECHANISMS OF VISUOSPATIAL ORIENTATION

视觉空间定向的感知机制

基本信息

批准号：
6372442
负责人：
CHARLES J DUFFY
金额：
$ 28.71万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2000
资助国家：
美国
起止时间：
2000-04-15 至 2005-03-31
项目状态：
已结题

项目摘要

Visuospatial orientation is the knowledge of one's location that allows navigation through the environment. It relies on optic flow to monitor the path of self-movement and object vision to monitor relative position. If optic flow and object cues for spatial orientation are processed separately in dorsal and ventral visual areas, they might function separately and interact differently with memory, motor control, and vestibular systems. I will assess the independence of optic flow and object vision in visuospatial processing by testing three specific hypotheses: 1) That object vision dominates heading memory because of strong connections between ventral visual areas and the hippocampus. 2) That optic flow dominates heading motor control because of strong connections between dorsal visual areas and motor centers. 3) That real movement interacts more with optic flow than object cues because cortical vestibular centers are more closely connected to dorsal visual areas. I will test these hypotheses in normal subjects by presenting optic flow and object stimuli as cues about the heading of self-movement in three experiments: 1) pointing to a remembered heading, 2) manual steering toward a target heading, and 3) heading perception during real translational movement. My goals are to characterize the perceptual mechanisms of visuospatial orientation, relate cognitive function to neural organization, and examine the applicability of the dual pathways view to visuospatial information processing. I will use the same approach in a parallel analysis of visuospatial disorientation, a common and debilitating aspect of Alzheimer's disease (AD). These studies will test whether impaired optic flow perception in AD is separate from deficits in object vision by identifying double dissociations between impaired cue use in visuospatial tasks. My goal is to integrate visual psychophysics and the analysis of visuospatial deficits to develop the requisite scientific foundation for clinical studies of visuospatial disorientation in AD.

视觉空间方向是对一个人的位置知识，该位置允许在环境中导航。它依靠视频流来监视自动移动和对象视觉的路径来监视相对位置。如果在背侧和腹侧视觉区域分别处理用于空间取向的视流和对象提示，它们可能会分别发挥作用，并且与内存，运动控制和前庭系统的相互作用不同。我将通过测试三个特定的假设来评估视觉处理过程中视觉和物体视觉的独立性：1）由于腹侧视觉区域与海马之间的牢固联系，对象视觉主导着头部记忆。 2）由于背视觉区域和运动中心之间的牢固连接，视频流占主导地位的电动机控制。 3）实际运动与光流相比，而不是对象提示，因为皮质前庭中心与背侧视觉区域更紧密地连接。我将通过提出光流和对象刺激来检验正常受试者中的这些假设，作为三个实验中自动移动标题的线索：1）指向记忆的标题，2）手动转向目标标题，3）在实际翻译过程中进行标题感知。我的目标是表征视觉空间取向的感知机制，将认知功能与神经组织联系起来，并检查双重途径视图对视觉空间信息处理的适用性。我将在视觉空间迷失方向的平行分析中使用相同的方法，这是阿尔茨海默氏病（AD）的常见和令人衰弱的方面。这些研究将通过确定视觉空间任务中的提示使用受损之间的双重解离，来测试AD中的视觉流动感知是否与对象视觉中的缺陷分开。我的目标是整合视觉心理物理学和视觉空间缺陷的分析，以为AD中视觉空间迷失方向的临床研究开发必要的科学基础。